Navigation Links
Longer-Lived Rodents Have Lower Levels of Thyroid Hormone

The thyroid may play an important role in longevity, with longer-lived rodents showing significantly lower levels of a thyroid hormone that speeds metabolism, a new study has found.//

The study further strengthens the theory that the faster an animal’s metabolism, the shorter its life, and vice versa, said Mario Pinto, the study’s lead author. The thyroid releases hormones that regulate metabolic rate.

“Thyroid hormones are key regulators of metabolism and have been widely implicated to influence longevity,” the authors wrote. Pinto will present the study “Differential thyroid hormone activity in rodents with different life spans” at a poster session Oct. 9 at Comparative Physiology 2006: Integrating Diversity. The study was carried out by Pinto and Rochelle Buffenstein, City College of New York.

Thyroid key to metabolic rate

The thyroid gland produces thyroxine (T4) which converts to triiodothyronine (T3) in the presence of iodine. T3 is the active component of T4 and is the key hormone in regulating metabolism, Pinto said. When an animal becomes cold, for example, its body converts T4 to T3 to speed metabolism and warm the body, he explained.

'Mice strains that exhibit extended longevity tend to have lower thyroid hormone concentrations than shorter living strains,' the authors wrote. 'Significant declines in thyroid hormone correlate well with enhanced maximum lifespan.'

The study compared the levels of these thyroid hormones among four groups of rodents with different life spans: mice, guinea pigs, Damara mole-rats and naked mole-rats. Mice live to about three and a half years; guinea pigs live to six years; Damara mole-rats to 15 years; and naked mole-rats to 28 years.

The animals were of different ages, but at comparable points in their life spans. For example, the mole-rats, which live 28 years, were two years old. The mice, which live about 3.5 years, were six months old. The s tudy determined the levels of T3 and T4 for each animal.

T4 levels vary the most

T4 levels varied significantly between all of the groups, with the shorter-lived groups having higher levels of T4 than longer-lived groups. The mice, for example, had twice as much T4 as the Damara mole-rats and had and three times more than that of the naked mole-rats, Pinto reported. There was also a significant difference in T3 levels between the naked mole-rats and the guinea pigs, but not between any of the other groups.

'These hormone concentration differences correlate with maximum species lifespan and suggest an important regulatory role of thyroid hormone in longevity,' the researchers concluded. However, because T3 levels did not differ significantly among all the groups, further research in this area using larger sample sizes (numbers of rodents in each group) is needed, Pinto said.


Related medicine news :

1. Rodents to be replaced with Dogs for cancer Research
2. Glucose Causes Death of Brain Cells in Rodents Following Hypoglycemic Coma
3. Simvastatin Plus Niacin May Lower Heart Risks
4. Ritalin May Lower Cocaine Abuse
5. Eating More Often May Help Lower Cholesterol
6. Lower surgical volume linked to higher death rate
7. Lowering blood pressure beneficial for PAD patients
8. Lower chance of bone fracture with Vitamin D supplementation
9. Tea Pill Lowers Cholesterol
10. Aspirin Lowers Leukemia Risk
11. Almonds Help Lower Cholesterol
Post Your Comments:

(Date:6/26/2016)... Lake Orion, Clarkston, Michigan (PRWEB) , ... June ... ... direction with respect to fertility once they have been diagnosed with endometriosis. These ... tolerable intercourse but they also require a comprehensive approach that can help for ...
(Date:6/25/2016)... Aliso Viejo, California (PRWEB) , ... June 25, 2016 , ... ... preset to fit their specific project," said Christina Austin - CEO of Pixel Film ... all fully customizable and all within Final Cut Pro X . Simply select ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, ... Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments in ... the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... ... is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Belgium , June 24, 2016 ... the appointment of Dr. Edward Futcher ... Non-Executive Director, effective June 23, 2016.Dr. Futcher was ... Nominations and Governance Committees.  As a non-executive member ... independent expertise and strategic counsel to VolitionRx in ...
(Date:6/23/2016)... , June 23, 2016 Research ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, ... (Oral, Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is ... a CAGR of 6.1% in the forecast period 2016 ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... 52" report to their offering. ... creates a favourable commercial environment for MedImmune to enter. The ... that will serve to drive considerable growth for effective anti-influenza ... to cap sales considerably, but development is still in its ...
Breaking Medicine Technology: