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Long-term Use of Herceptin Does Not Increase Heart Failure in Patients

sitive breast cancer, it also causes an increased risk for congestive heart failure a 4.1 percent incidence of congestive health failure was reported in the Herceptin and chemotherapy group compared to a 0.8 percent increase in the control group.

The current study found that after five years follow-up, the incidence of congestive heart failure was virtually unchanged 3.8 percent of patients who received Herceptin and chemotherapy experienced congestive heart failure, compared to 0.9 percent of patients in the control group. Congestive heart failure was measured using a Multiple Gated Acquisition scan, or a MUGA scan a noninvasive tool that produces a moving image of the beating heart to determine the health of the cardiac ventricles.

The research team also identified possible risk factors for breast cancer patients more likely to develop congestive heart failure from adding Herceptin to combination chemotherapy. They developed a prediction model based on these factors, including hypertension, age and baseline cardiac function.

It is our hope that this model will help to individualize care for women in terms of choice of Herceptin-containing treatment regimens based on their personal risk and benefits, said Dr. Rastogi.


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