Navigation Links
Long-term Use of Herceptin Does Not Increase Heart Failure in Patients

CHICAGO, A five-year follow-up of National Surgical Adjuvant Breast and Bowel Project (NSABP) trial B-31, presented at the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago states that the risk of congestive heart failure in women treated with trastuzumab (Herceptin) and combination chemotherapy for early-stage breast cancer did not increase over time.

The research team developed a prediction model based on these findings. The model will help oncologists to assess the risk of heart failure in individual breast cancer patients before treatment with Herceptin and chemotherapy. These findings, to be announced at the Womens Cancers press briefing at the meeting, will be published in Abstract LBA513 in the ASCO proceedings.

The information we obtained from this study is essential to understanding womens risks for congestive heart failure associated with adding Herceptin to combination chemotherapy for breast cancer treatment, said Priya Rastogi, M.D., study presenter and assistant professor, University of Pittsburgh School of Medicine and assistant director of medical affairs, NSABP. Were encouraged that we found no increase in heart failure risks long-term and now are able to use this knowledge to individualize womens treatment based on their specific cardiac risk factors.

The study assessed cardiac side effects in 1,850 women with HER-2 positive breast cancer those who have abnormally high levels of the HER2/neu protein for five years. Study participants were initially randomized to receive four cycles of a standard combination chemotherapy regimen, doxorubicin and cyclophosphamide followed by paclitaxel, or doxorubicin and cyclophosphamide followed by paclitaxel and Herceptin.

The incidence of congestive heart failure was compared between the two groups. Initial three-year follow-up results reported that although Herceptin provides a clear and notable benefit to women with HER-2 po sitive breast cancer, it also causes an increased risk for congestive heart failure a 4.1 percent incidence of congestive health failure was reported in the Herceptin and chemotherapy group compared to a 0.8 percent increase in the control group.

The current study found that after five years follow-up, the incidence of congestive heart failure was virtually unchanged 3.8 percent of patients who received Herceptin and chemotherapy experienced congestive heart failure, compared to 0.9 percent of patients in the control group. Congestive heart failure was measured using a Multiple Gated Acquisition scan, or a MUGA scan a noninvasive tool that produces a moving image of the beating heart to determine the health of the cardiac ventricles.

The research team also identified possible risk factors for breast cancer patients more likely to develop congestive heart failure from adding Herceptin to combination chemotherapy. They developed a prediction model based on these factors, including hypertension, age and baseline cardiac function.

It is our hope that this model will help to individualize care for women in terms of choice of Herceptin-containing treatment regimens based on their personal risk and benefits, said Dr. Rastogi.


'"/>




Related medicine news :

1. Long-term use of calcium supplements to prevent colon cancer
2. Long-term Care Should Be A Planned Affair
3. Long-term Ibuprofen Therapy After Brain Injury Deteriorate Cognitive Abilities
4. Global AIDS Conference Calls for Long-term Strategies
5. Long-term Use of Stomach Drugs may Weaken Bones
6. Asthma Sufferers Favor Quick Relief Over Long-term Control
7. Long-term Marijuana Smoking Leads to Respiratory Complaints
8. Tamoxifen Yields Long-term Reduction in Breast Cancer Risk
9. Angioplasty Reduces Long-term Cardiac Risk in Heart Patients With silent Ischemia
10. Functional Foods Must Be Monitored to Assess Their Long-term Safety and Effectiveness
11. Cancer Drug Induces HDAC Inhibitor and Enhance Long-term Memory
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/22/2017)... Matthews, NC (PRWEB) , ... May 22, 2017 ... ... of Matthews Periodontics, is now welcoming new patients with periodontal plastic surgery treatments, ... referral from a general dentist. Dr. Green provides these esthetic and functional procedures ...
(Date:5/22/2017)... ... May 22, 2017 , ... Faithfully following pop culture, people today ... jumped, toned and shaped through fitness programs. It carries on to skin nourished, pampered ... with an irresistible, radiant smile. CDA has found that just like a ...
(Date:5/21/2017)... ... May 20, 2017 , ... GetLinked® ... Services and financial systems. , Dozens of clubs using ABC Financial Services ... processed through GetLinked into their club’s accounting system , The latest implementation is ...
(Date:5/21/2017)... ... May 21, 2017 , ... For more than 20 ... a wide range of knives and swords, from functional to fantasy. United Cutlery has ... with sleek, modern designs that defy tradition. , Offering a range of weapons and ...
(Date:5/19/2017)... ... May 19, 2017 , ... DMG Productions is proud ... Innovations with Ed Begley, Jr., airing fourth quarter 2017 on FOX Business. , ... organic dietary supplement made from naturally occurring ingredients. Innovations will enlighten viewers on ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... Inc. (Nasdaq: HOLX ) announced today the ... April 1, 2017 .   GAAP diluted earnings per ... prior year period as the sale of the blood ... diluted EPS of $0.50 increased 6.4%.  Revenue of $715.4 ... Excluding the effects of blood screening and the acquired ...
(Date:5/9/2017)... , May 9, 2017 Zimmer Biomet ... in musculoskeletal healthcare, today announced it has earned a ... of 2017" list. The Company was ranked among 500 ... Large Employers and Healthcare Equipment and Services. ... based on an anonymous, independent survey of over 30,000 ...
(Date:5/8/2017)... Mich. , May 8, 2017  Diplomat Pharmacy, ... WRB Communications, Inc. ("WRB"), a health care service ... . WRB specializes in relationship management programs ... WRB will join ... Diplomat,s commercialization support services for manufacturers, biotech firms, and ...
Breaking Medicine Technology: