Navigation Links
Long-life genes - A new way to combat cancer…

n the worm. Life span is influenced by cells in the reproductive system and sensory neurons in the brain.

In the study, the team mutated a tumor suppressor gene called gld-1 in the worms, causing cells in the animals' gonads to divide rapidly and form germ-line tumors. These tumor cells, when left undisturbed, break out of the gonad and fill the body, killing the worm at around 9 days old age.

They then studied the effects of a few different 'longevity' genes in the tumor-affected animals, to assess the influence on lifespan and tumor growth. All of the longevity mutations tested increased the worms' lifespan in spite of them having cancer.

It is a long known fact that insulin boosts growth of tumor in rats. When the insulin levels are reduced in rats by making them diabetic, the tumor growth also slows down. "The study is another example of the intimate tie-in between insulin and tumorigenesis," says David Kritchevsky from the Wistar Institute in Philadelphia, Pennsylvania, who studies the effects of diet on cancer.

“In the worms, lowering insulin levels seems to slow cell division and increase apoptosis - the process by which some cells are able to commit suicide — with a particular impact on tumor cells.”

The results indicate that tumor cells are generally more susceptible to the effects of longevity-causing mutations than normal cells. Thus, investigating these long-life mechanisms might provide better ways to fight cancer. Drugs created this way might even have the side effect of extending life further than the normal span for those without cancer.

This study is a significant start in this direction: the short lifespan of the worms makes for a quick study of old age. More human-like models will need to be studied to unravel what is really going on say other experts.

Biologist Siegfried Hekimi of McGill University in Montreal, who studies C. elegans, warns that the labora
'"/>




Page: 1 2 3

Related medicine news :

1. Cirrhosis linked to genes
2. Altering genes through calories
3. Predictable genes
4. Endometriosis coalesced with genes
5. Birth weight may be influenced by genes
6. New breast cancer genes discovered
7. Altitude sickness connected to genes
8. Jumping genes eliminate sections of DNA
9. Multiple organ disease cured by genes
10. Function of genes in heart failure
11. Discovering cholesterol-absorbing genes
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Long life genes new way combat cancer

(Date:6/30/2015)... ... , ... The LIV Fertility Center in Puerto Vallarta is taking ... to pursue egg freezing. Statistics show that 20 percent of women are waiting to ... increase since the 1970s. , Sadly, for women who have delayed parenthood for a ...
(Date:6/30/2015)... , ... June 30, 2015 , ... The American Lung ... at a media event in San Diego. Speakers and clean air advocates included San ... medicine, Natalie Germuska of Kindred Hospital, and Daniel Sullivan, founder and president of Sullivan ...
(Date:6/30/2015)... Ohio (PRWEB) , ... June 30, 2015 , ... ... services nationwide, announces today that they have been awarded the exclusive billing agreements ... a full range of billing services encompassing their proprietary suite of billing process ...
(Date:6/30/2015)... Long Beach, CA (PRWEB) , ... June 30, 2015 , ... ... Sea Skilled Nursing”, which features multiple patient and family member testimonials. Medicare rated the ... the country. Broadway plans to use the video to give future patients a firsthand ...
(Date:6/30/2015)... ... 2015 , ... Family and professional dementia caregivers are invited ... 9, 2015 at the Hyatt Regency Denver Tech Center from 7:30 am-4:30 pm. ... Campbell, the wife and daughter of singer Glen Campbell, who will discuss their ...
Breaking Medicine News(10 mins):Health News:LIV Fertility Center Educating Women on the Critical Timing of Egg Freezing 2Health News:LIV Fertility Center Educating Women on the Critical Timing of Egg Freezing 3Health News:LIV Fertility Center Educating Women on the Critical Timing of Egg Freezing 4Health News:LIV Fertility Center Educating Women on the Critical Timing of Egg Freezing 5Health News:Local Dignitaries Gather to Announce San Diego’s Clean Air Challenge 2Health News:Local Dignitaries Gather to Announce San Diego’s Clean Air Challenge 3Health News:ADVOCATE Wins Billing Agreements with Jackson Radiology Associates 2Health News:Broadway by the Sea Video Promotes Top Quality Service 2Health News:Family of Singer Glen Campbell to Discuss Living with Dementia at the Alzheimer's Association of Colorado's 26th Annual Education Symposium 2
... is available in French . , Pediatric ... a massive boost today, following the Cole Foundation,s announcement that ... 10 Universit de Montral and four McGill University young scientists. ... and lymphomas in people under the age of 25, and ...
... , TUESDAY, May 17 (HealthDay News) -- A ... affect production of the pregnancy hormone progesterone and may be ... The Johns Hopkins University team looked at more than ... and identified nine who had the variation of the scavenger ...
... four years of remarkable progress including pioneering discoveries ... Medical Research Institute (SMRI) today announced that it will ... Institute,s Stanley Center for Psychiatric Research. Launched ... the SMRI, the Stanley Center brings together scientists from ...
... Mozes HealthDay Reporter , MONDAY, May 16 (HealthDay News) ... elevate "bad" cholesterol levels, and may in fact prompt a very ... , The finding comes from a six-month examination of the ... of healthy people in England. , , "The issue is that ...
... It is important for health care providers to report health ... there is evidence of a reluctance to share patient data ... privacy and provider confidentiality. Dr. Khaled El-Emam and his research ... protocol and system that would solve this problem. The ...
... by the UK journal Reproductive Health Matters shows ... the development of a vast illegal private sector with no ... became illegal in the late 1980s the number of abortions ... trade in abortions is, however, flourishing, with abortion providers advertising ...
Cached Medicine News:Health News:Cole Foundation injects $700,000 into childhood cancer research 2Health News:Gene Variation May Explain Some Female Infertility Cases 2Health News:Grant extends funding for the Broad's Stanley Center for Psychiatric Research 2Health News:Selenium Supplements Might Give Modest Benefit Against Cholesterol 2Health News:Selenium Supplements Might Give Modest Benefit Against Cholesterol 3Health News:CHEO Research Institute develops secure protocol for data disclosure 2Health News:Abortions generate $95 million a year for Polish doctors as women use illegal private sector 2
(Date:6/30/2015)... Calif. , June 30, 2015  Ardelyx, Inc. ... on cardio-renal, gastrointestinal and metabolic diseases, today announced that ... July 14, 2015, from 8:00 a.m.- 1:00 pm EDT ... The Ardelyx senior management team will present ... lead compound, tenapanor, which has completed Phase 2b clinical ...
(Date:6/30/2015)... , BERKELEY, Kalifornien, und KOPENHAGEN, Dänemark, ... Biologics, Inc. , ein Weltmarktführer der klinischen ... anderen therapeutischen Proteinen, gab heute bekannt, dass ... der Produktionskapazität den Ausbau der nordamerikanischen Produktionsanlage ... mit der Ergänzung  einer Einweg-Anlage Bioreactor 6Pack™ ...
(Date:6/30/2015)... , June 24, 2015 Research ... of the "Global Endoscopy Devices Market 2015-2019" ... global endoscopy devices market to grow at a ... The global endoscopy devices market can be segmented ... accessories, and services. The market can be further ...
Breaking Medicine Technology:Ardelyx to Host Inaugural R&D Investor Day in New York City on July 14, 2015 2CMC Biologics baut GMP-Produktionskapazität in den USA aus 2CMC Biologics baut GMP-Produktionskapazität in den USA aus 3Global Endoscopy Devices Market 2015-2019 - Key Players are Boston Scientific, Johnson and Johnson, Medtronic, Karl Storz & Olympus 2Global Endoscopy Devices Market 2015-2019 - Key Players are Boston Scientific, Johnson and Johnson, Medtronic, Karl Storz & Olympus 3
... (Nasdaq: ISIS ), the leader in antisense therapeutics, ... Stifel Nicolaus, Healthcare Conference 2011 on Thursday, September 08, 2011 ... Boston. A live audio webcast of the presentation ... the Company,s Web site, www.isispharm.com .  A replay of ...
... Sequenom, Inc. (NASDAQ: SQNM ), a life ... Company,s participation at the William Blair and Company 5th Annual ... Hotel in New York City on September 8, 2011. ... Research and Development, will present on Thursday, September 8, 2011 ...
Cached Medicine Technology:Sequenom Announces Participation at William Blair and Company 5th Annual Emerging Growth Stock Conference 2
... If you prefer a standard ... the Volk Iridectomy Lens. Its ... view you're used to but ... Volk's exclusive Double Aspheric design ...
... 2.2 offers extremely high resolution treatment capability ... an exceptionally wide 78° field of view. ... critical evaluation of the optic nerve head ... of the macula and disc. Redesigned to ...
... for focal laser therapy and mid-to-far peripheral ... a realistic contour of the retinal concavity, ... entire posterior pole extending to the equator. ... dynamic movement on the globe, therefore increasing ...
... The Digital 1.0x Imaging Lens is optimized ... reduce glare and reflections during general diagnosis and ... view of the posterior pole and a sharper ... Digital 1.0 X Imaging Lens is also ideal ...
Medicine Products: