According to an anti-ageing research, the liver is a neglected key. Professor David Le Couteu, a geriatrician, of the Concord Hospital, felt that there are many wonderful things about getting older, with a background in clinical pharmacology and toxicology.//Your mortgage is paid off, your children have moved out, you're not embarrassed about who you are, and you have the benefit of wisdom and resilience," he said.

"It would be fine if it wasn't for dementia, arthritis, heart disease, cancer, and pneumonia. This is why we are actively investigating new ways to prevent age-related disease." Professor Le Couteur said that many age-related illnesses were caused by toxins and fats and that this is where his interest in the liver came from.

The liver's role in the body is to process blood coming from the gut by absorbing nutrients, metabolising fats, and processing toxins. "Previous to our research, the liver was not thought to change much during ageing, except for shrinking in size," he said.

However Professor Le Couteur and colleague Allan McLean of the National Ageing Research Institute in Melbourne have discovered that as the liver ages, its blood vessels also change. The blood vessels in a healthy liver have tiny holes in their walls to allow blood going from the gut into the liver to be processed.

Professor Le Couteur and team have found that in rats, baboons, and humans these tiny holes seem to clog up or disappear as the liver ages. "This means that fats and toxins can't get processed properly," he said. "And it explains a lot of problems." For example, he said, the fats involved in atherosclerosis — the build-up on blood vessel walls — float around in the blood because they are unable to be processed properly in the liver.

In an article due to appear in medical journal The Lancet next month, Professor Le Couteur argues that the age-related increase in atherosclerosis is due to these age-related changes in
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