Navigation Links
Liver an Excellent Target For Cancer Gene Therapy

pped gene therapy research and spawned widespread safety concerns about gene therapy involving the liver.

“At that time, I was treating patients with colon cancer that had spread to the liver using a very similar adenoviral vector administered in exactly the same way – direct infusion into the main artery feeding the liver,” said Reid, who is now an associate professor of clinical medicine in the UCSD School of Medicine. “We saw virtually no problems with toxicity in 35 study participants who received a total of nearly 200 infusions across several study sites.”

So Reid and colleagues carefully re-analyzed the data from the 17 participants from the Stanford site to determine the impact of repeated adenoviral exposure on liver function, and documented that there were no significant problems. While the analysis was not designed to demonstrate impact on disease, it showed that seven of the 17 patients had stable-to-improving disease at the completion of four viral infusions. The researchers then demonstrated that normal liver cells could not be infected with an adenovirus, which led them to investigate where the receptor was located. They found it hiding at the junction between liver cells and proved that it was inaccessible from the blood flow in the liver. From there they showed that cancer cells had lost structural polarity, resulting in random distribution of CAR receptors on their surface, thereby allowing the virus to attach to and infect the tumor cells.

“In the process of proving that liver toxicity is not an issue in gene therapy, we have also shown that cancer cells metastatic to the liver are a perfect target for gene therapy because the cancer cells, but not the normal liver cells, are infected by the adenoviral vector,” said Reid. “We also found that other cancer cells, including those from the breast, pancreas and prostate, are readily infected by adenoviral vectors indicating disorganized expression of the CAR receptor
'"/>




Page: 1 2 3

Related medicine news :

1. Blood Cells Capable of Regenerating Liver
2. Liver donors can thrive after transplant
3. Heavy Drinking Raises Risk of Liver Cancer
4. Arthritis Drug May Cause Liver Damage
5. Liver transplant oversight urged
6. Liver key to extending life
7. Liver cancers which spread are linked to a particular gene
8. Liver diseases: The enemy with an accomplice
9. Troubled Childhood found to affect your Liver
10. New Liver Tumor Treatment
11. Transplants Help Liver Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Liver Excellent Target For Cancer Gene Therapy

(Date:8/27/2014)... StartX , a nonprofit technology accelerator ... a pioneering institute driving biotechnology innovation at the University ... laboratory customized for the needs of early stage medical ... lab space, named “StartX-QB3 Labs,” is the first research ... Care focused on developing entrepreneurs from academia to industry. ...
(Date:8/27/2014)... August 27, 2014 For the first ... face on plastic surgery when triple-board certified, Park Avenue ... figurative clay sculptures he has created from life – ... and artistry at a unique event on September 9, ... at 23 Warren Street. The “faces” who will be ...
(Date:8/27/2014)... Humility of Mary Health Partners will offer SlimDown, ... Center in Boardman beginning Sept. 2 and at St. ... , SlimDown teaches participants to manage their weight by ... and behavior. , Classes run from 5:30 to 6:30 ... Mondays at St. Joe’s at the Mall. , The ...
(Date:8/27/2014)... 27, 2014 Two of Woodland Hills’ ... Jivraj of the Anacapa Dental Art Institute, deal with serious ... complex oral surgery. , So patients can be reluctant to ... sores left from biting their lip or gums. , “The ... by the accidental bite,” Dr. Reshad said. “This canker or ...
(Date:8/27/2014)... A recent news article in the Richmond, ... “Five tips for relieving dry skin.” Sharon Kleyne, international ... Power of Water radio show describes the article’s five ... are seldom reported but which, Kleyne believes, are equally ... is Founder of Bio Logic Aqua Research, a global ...
Breaking Medicine News(10 mins):Health News:StartX & QB3 Launch Lab for Life Science and Medical Technology Entrepreneurs 2Health News:StartX & QB3 Launch Lab for Life Science and Medical Technology Entrepreneurs 3Health News:StartX & QB3 Launch Lab for Life Science and Medical Technology Entrepreneurs 4Health News:Presenting A Remarkable Fusion of Art, Fashion and Plastic Surgery 2Health News:Humility of Mary Health Partners Offers SlimDown Classes 2Health News:Two of Ventura’s Best Cosmetic Dentists Offer 5 Tips for Dealing with Frequent Tongue or Lip Biting 2Health News:Two of Ventura’s Best Cosmetic Dentists Offer 5 Tips for Dealing with Frequent Tongue or Lip Biting 3Health News:Two of Ventura’s Best Cosmetic Dentists Offer 5 Tips for Dealing with Frequent Tongue or Lip Biting 4Health News:Two of Ventura’s Best Cosmetic Dentists Offer 5 Tips for Dealing with Frequent Tongue or Lip Biting 5Health News:Water Advocate Sharon Kleyne Reports New Discoveries for Relief of Dry Dehydrated Skin 2Health News:Water Advocate Sharon Kleyne Reports New Discoveries for Relief of Dry Dehydrated Skin 3
... as a potential heart disease therapy, raising high-density lipoprotein ... protein may not be effective, a new study suggests. ... Center on Aging (USDA HNRCA) at Tufts University ... between low plasma cholesterol ester transfer protein (CETP) activity ...
... ... Intelligence Agency has requested documents from an investigative journalist, even though the writer had ... , ... 15, 2009 -- In a bizarre about-face, the secretive Central Intelligence Agency has requested ...
... ... ... -- The popularity and hype surrounding buttock augmentation and other large-volume body enhancing injections ... deadly trend, cautions the Physicians Coalition for Injectable Safety . Permanent fillers ...
... for inflammatory marker may spot people in need of ... -- People with normal levels of LDL (bad) cholesterol ... inflammation in order to identify those who may benefit ... of heart attack, stroke and death, say U.S. researchers. ...
... , , PALM ... Inc. (Pink Sheets: CTYX) announced today that it has ... Sheets (Pink Sheets Current Information). The higher move ... Information available. http://www.pinksheets.com/content/doc/ps/Disclosure/Guidelines/2.pdf , Connectyx President Ronn ...
... Dec. 15 At a time when Americans spend over ... Dr. Raymond Hall is theorizing a painful connection between conventional ... Pillo1 ( www.pillo1.com ) to address the problem. A ... Sleep Disorders Center showed that Pillo1 re-educates the body to ...
Cached Medicine News:Health News:Low cholesterol transfer protein activity associated with heart disease risk 2Health News:CIA Requests its Own Documents from Author 2Health News:CIA Requests its Own Documents from Author 3Health News:Physicians Coalition for Injectable Safety Warns Buttock-Boosting Injections Risky and Deadly 2Health News:Physicians Coalition for Injectable Safety Warns Buttock-Boosting Injections Risky and Deadly 3Health News:Physicians Coalition for Injectable Safety Warns Buttock-Boosting Injections Risky and Deadly 4Health News:Normal Cholesterol Doesn't Guarantee Healthy Heart 2Health News:Connectyx Attains 'Current Listing' Status on Pink Sheets Exchange 2Health News:Connectyx Attains 'Current Listing' Status on Pink Sheets Exchange 3Health News:Sleep Study Shows Pillo1 Re-Educates Body to Naturally Move Into Optimal Sleep Position and Increases REM Sleep by 21.3% 2
(Date:8/26/2014)... Aug. 26, 2014  Ethicon* is introducing three new ... unique challenges of bariatric procedures such as sleeve gastrectomy ... today at the 19th World Congress of International Federation ... 2014), where Ethicon is featuring the new ECHELON FLEX ... ® G2 Articulating Tissue Sealer alongside the HARMONIC ...
(Date:8/26/2014)... 26, 2014 SynCardia Systems, Inc., manufacturer of ... the Inc. 5000 named by the business magazine ... FDA, Health Canada and CE approved Total Artificial Heart, ... donor heart transplant," says Michael P. Garippa , ... of care for patients dying from end-stage biventricular heart ...
(Date:8/26/2014)... , Aug. 26, 2014    Practice Fusion ... (EHR) platform , today announced the addition to its ... company,s chief commercial officer and Joe Priest ... the heels of Practice Fusion,s recent hire of Robert ... further expansion of the company,s executive bench. With the ...
Breaking Medicine Technology:Ethicon Expands Bariatric Surgery Portfolio; Unveils "Evidence Corner" At IFSO To Address Obesity And Metabolic Diseases 2Ethicon Expands Bariatric Surgery Portfolio; Unveils "Evidence Corner" At IFSO To Address Obesity And Metabolic Diseases 3Ethicon Expands Bariatric Surgery Portfolio; Unveils "Evidence Corner" At IFSO To Address Obesity And Metabolic Diseases 4Ethicon Expands Bariatric Surgery Portfolio; Unveils "Evidence Corner" At IFSO To Address Obesity And Metabolic Diseases 5Ethicon Expands Bariatric Surgery Portfolio; Unveils "Evidence Corner" At IFSO To Address Obesity And Metabolic Diseases 6Inc. Magazine Ranks SynCardia Systems in Top 3rd in its 2014 Inc. 5000 List 2Practice Fusion Further Expands Executive Team with Chief Commercial Officer and VP of Pharmaceutical Partnerships Hires 2Practice Fusion Further Expands Executive Team with Chief Commercial Officer and VP of Pharmaceutical Partnerships Hires 3
... Sysmex, a global leader in medical diagnostic testing ... organizational changes that further position the company,s North ... John Kershaw, President & CEO, Sysmex America, Inc. ... Executive Vice President, Marketing, Business Development and Medical/Scientific ...
... 2010 HeartSine Technologies received the Outstanding ... Awards ceremony, November 25th, in Belfast, Northern Ireland. The ... contributions to Belfast and surrounding communities. The ... Group in 1997 to honor champions and ambassadors ...
Cached Medicine Technology:Sysmex America Announces Executive Promotions 2HeartSine Technologies Wins 2010 Aisling Award for Outstanding Achievement in Business 2
An immunochromatographic rapid test for the detection of Plasmodium falciparum in whole blood....
Malaria device / strip (2 line, PAN specific-pLDH)...
Malaria device / strip (3 line, P.f/P.v Ag Test-pLDH)...
High sensitive, specific one step immunochromatographic assay for human infectious disease...
Medicine Products: