Navigation Links
Liver an Excellent Target For Cancer Gene Therapy

A study demonstrates that cancer cells in the liver are excellent targets for gene therapy using adenoviral vectors//. It is based upon a fundamental new understanding of the differences between cancerous and normal liver cells. The findings signal a new way to treat cancers that have spread to the liver, such as metastatic cancers of the colon and breast.

The research team, led by Tony Reid, M.D., Ph.D., of the Moores Cancer Center at University of California, San Diego (UCSD), reports that in normal liver cells there is only one receptor – or doorway the vector uses to enter the cell. This doorway is located at the base of normal liver cells, hidden from the blood vessels. The research also demonstrates that in cancerous cells the receptor for adenovirus, called the coxsackie-adenoviral receptor or CAR, is expressed randomly over the surface of the cell and is exposed to the blood vessels.

“Since the receptor is distributed randomly on the surface of tumor cells, the doorway is open for the adenoviral vectors circulating in the blood stream to infect and kill these cells,” said Reid, who was at Stanford University when this work was conducted. “At the same time, normal liver cells are protected. These findings may signal a new way to treat any cancer that has spread to the liver.”

Reid explained: “We are taking advantage of a fundamental characteristic of cancer cells – structural disorganization. The disorganized structure of the cancer cells exposes the receptors so that Onyx-015, the adenoviral vectors used in this study, can readily enter tumor cells. This may be the first time a therapy has been directed against the disorganized nature of cancer cells.”

Reid and his colleagues undertook this study following the death of Jesse Gelsinger, a participant in a gene therapy clinical trial at University of Pennsylvania for ornithine transcarbanoylase (OTC) deficiency, a metabolic liver disorder. That case virtually sto
'"/>




Page: 1 2 3

Related medicine news :

1. Blood Cells Capable of Regenerating Liver
2. Liver donors can thrive after transplant
3. Heavy Drinking Raises Risk of Liver Cancer
4. Arthritis Drug May Cause Liver Damage
5. Liver transplant oversight urged
6. Liver key to extending life
7. Liver cancers which spread are linked to a particular gene
8. Liver diseases: The enemy with an accomplice
9. Troubled Childhood found to affect your Liver
10. New Liver Tumor Treatment
11. Transplants Help Liver Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Liver Excellent Target For Cancer Gene Therapy

(Date:7/31/2014)... 31, 2014 According to a report by ... underwent partial knee replacement surgery on his left knee. This ... months earlier. The story also reports that Bush was able ... to be back on the bike again soon. This high ... of partial knee replacement. , “Partial knee replacements give ...
(Date:7/31/2014)... 31, 2014 Recognizing that today’s medical ... Nutrition Healthcare Conference announced today its student discount ... of medicine or a healthcare-related field, as well as ... student-only discounts for the conference, scheduled for September 17-20, ... Bay Resort. , “As a future Registered ...
(Date:7/31/2014)... 31, 2014 ProtonPACS, a division of ... the National Rural Health Association (NRHA), company officials announced ... understanding the needs of rural health providers nationwide. , ... Health Association,” said Dr. Mark Awh, President of Radsource. ... of ProtonPACS, we are also looking forward to learning ...
(Date:7/31/2014)... The shale gas development that has vaulted ... U.S. natural gas production has raised concerns that local ... similar to previous resource extraction experiences in Pennsylvania’s history. ... & Jefferson College’s (W&J) Center for Energy Policy & ... that the gas boom in Pennsylvania is still underway, ...
(Date:7/31/2014)... Los Angeles, CA (August 1, 2014) While it is ... more likely to use alcohol, a new study finds ... likely to drink than their civilian counterparts. This study ... , a SAGE journal published on behalf of the ... Teachman, Carter Anderson, and Lucky Tedrow studied surveys of ...
Breaking Medicine News(10 mins):Health News:George W. Bush’s Surgery Highlights the Benefits of Partial Knee Replacement 2Health News:Student Discounts Offered for International Plant-based Nutrition Healthcare Conference 2Health News:Student Discounts Offered for International Plant-based Nutrition Healthcare Conference 3Health News:ProtonPACS Announces Pipeline Partnership with the National Rural Health Association. 2Health News:Pennsylvania’s Shale Gas: Examining the Boom and Bust Cycle 2Health News:Pennsylvania’s Shale Gas: Examining the Boom and Bust Cycle 3Health News:Women in military less likely to drink than civilian women 2
... feeling blue, but are boring for those in a positive ... If you,re feeling sad, you,re more likely to crave your ... never eaten at before, because a negative mood makes the ... reverse seems to also be true, the study authors found: ...
... , ... ... ... ...
... ... ... ... ...
... ... Sciences , ... Czech Republic (PRWEB) February 23, 2010 -- Moravia Worldwide, a leading globalization solution provider, ... Translation 101". This webinar will address translation process optimization and automation opportunities that exist ...
... ... Dreams and Realities by Jeffrey T. Gorke -- the must-read playbook that maps out ... and find their "dream" practice. , ... Phoenix, MD (PRWEB) February 23, 2010 -- Whether just starting a ...
... ... ... ... ...
Cached Medicine News:Health News:Happy People More Likely to Try Something New 2Health News:Cristophe Salon in Beverly Hills Teams Up with 'Mad Men' Actor to Help Raise Money for His 17-Year-Old Cousin's Heart Transplant 2Health News:Cristophe Salon in Beverly Hills Teams Up with 'Mad Men' Actor to Help Raise Money for His 17-Year-Old Cousin's Heart Transplant 3Health News:Cristophe Salon in Beverly Hills Teams Up with 'Mad Men' Actor to Help Raise Money for His 17-Year-Old Cousin's Heart Transplant 4Health News:BUAV Exposes Shocking Role Played by Laos in the International Trade in Primates for Research 2Health News:BUAV Exposes Shocking Role Played by Laos in the International Trade in Primates for Research 3Health News:BUAV Exposes Shocking Role Played by Laos in the International Trade in Primates for Research 4Health News:BUAV Exposes Shocking Role Played by Laos in the International Trade in Primates for Research 5Health News:Moravia Worldwide to Present Webinar on Life Sciences Translation 101 2Health News:Moravia Worldwide to Present Webinar on Life Sciences Translation 101 3Health News:New Book Gives Physicians the Business Know-how to Find the Right Medical Practice 2Health News:Pew Report: Pennsylvania Failing to Address Children's Dental Health Crisis 2Health News:Pew Report: Pennsylvania Failing to Address Children's Dental Health Crisis 3Health News:Pew Report: Pennsylvania Failing to Address Children's Dental Health Crisis 4Health News:Pew Report: Pennsylvania Failing to Address Children's Dental Health Crisis 5Health News:Pew Report: Pennsylvania Failing to Address Children's Dental Health Crisis 6Health News:Pew Report: Pennsylvania Failing to Address Children's Dental Health Crisis 7
(Date:7/30/2014)...  El Camino Hospital, a leader in the use ... Leaf Patient Monitoring system to help prevent hospital-acquired pressure ... susceptible to bed sores. The decision was ... the system, which showed dramatic improvement in compliance with ... the one of the most effect ways to prevent ...
(Date:7/30/2014)... PITTSBURGH , July 30, 2014   ... Markets Groups Inc.: OTC Pink: UPZS), a Delaware ... a distribution agreement with Larasan Pharmaceutical Corporation ("Larasan"), a ... products.  According to the agreement, US-based Larasan will ... gourmet 6" frozen pizza through Larasan,s vast distribution ...
(Date:7/30/2014)... SANTA CLARA, Calif. , July 30, 2014 /PRNewswire/ ... innovation economy, released a study today that ... venture-backed biopharma and medical device companies.  According to the ... healthcare saw the biggest potential returns since SVB started ... the year of the IPO.  Built on solid healthcare ...
Breaking Medicine Technology:El Camino Hospital Utilizes Cutting-Edge Leaf Patient Monitor System to Help Reduce Risk of Pressure Ulcers 2El Camino Hospital Utilizes Cutting-Edge Leaf Patient Monitor System to Help Reduce Risk of Pressure Ulcers 3Unique Pizza and Subs Announces Asian Distribution Agreement with Larasan Pharmaceutical Corporation 2Unique Pizza and Subs Announces Asian Distribution Agreement with Larasan Pharmaceutical Corporation 3Report: Biopharma and Medical Device Companies Beat Historic Investment Returns 2Report: Biopharma and Medical Device Companies Beat Historic Investment Returns 3
...  IRIDEX Corporation (Nasdaq: IRIX ) announced ... of IRIDEX, MicroPulse laser therapy.  The study examined ... central serous chorioretinopathy (CSC).(1) The study concluded tissue-sparing ... for CSC, also known as CSR, an eye ...
... Texas, Jan. 25, 2012 UNT Health Science Center ... Myron (Mike) Jacobson, Ph.D., as the founding dean of ... search we were very pleased to recruit a renowned ... academic leader in pharmacy education, and a successful entrepreneur ...
Cached Medicine Technology:IRIDEX MicroPulse™ Laser Therapy Enhances Visual Function in Patients with Central Serous Chorioretinopathy (CSC) 2IRIDEX MicroPulse™ Laser Therapy Enhances Visual Function in Patients with Central Serous Chorioretinopathy (CSC) 3UNT System Names Jacobson Founding Dean of College of Pharmacy 2UNT System Names Jacobson Founding Dean of College of Pharmacy 3
... single-use instruments on the market., Available in standard ... Surgery. , Dual action tips provide maximum ... points to reduce the chance of alternative burn ... eliminates gapping at connection and the need for ...
Disposable sheath for use with 5mm AEM Laparoscopic Instruments ....
... AEM Laparoscopic Instruments incorporate a layered design ... shielded and monitored to prevent stray electrosurgical ... caused by insulation failure or capacitive coupling; ... shield built into all AEM Instruments provides ...
... AEM Laparoscopic Instruments incorporate a layered design ... shielded and monitored to prevent stray electrosurgical ... caused by insulation failure or capacitive coupling; ... shield built into all AEM Instruments provides ...
Medicine Products: