Navigation Links
Little Known DNA Repair Enzyme May Be A Tumor Suppressor Gene

s were different from normal cells, they found that the cells' chromosomes showed not only a dramatic ten-fold increase in the incidence of swapping and fusing of genes and other genetic material between chromosomes, but also an increase in the number of chromosomes compared to normal cells.

The high frequency of DNA rearrangements in Rev3L/p53-deficient cells suggests that pol zeta in normal cells is responsible for preventing double-stranded breaks in chromosomes. When pol zeta is absent, it leads to a massive amount of double-stranded breaks, some of which are repaired correctly and others that are repaired incorrectly by being fused to other genes or chromosomes.

These findings have significant implications for human cancer research, as such a high degree of chromosomal instability is a characteristic of cancer cells. Further, the human Rev3L gene is located in a segment of chromosome 6 which is home for multiple tumor suppressor genes and a slew of human cancers, including a number of leukemias and lymphomas. This segment is associated with chromosomal instabilities in this particular region of chromosome 6.

"Although it requires further investigation, we believe that mutations in this part of chromosome 6 could occur during the development of some cancers and this may have prognostic and therapeutic implications. We are now investigating this hypothesis by selectively deleting the Rev3L gene in adult mouse cells to study how the loss of DNA polymerase zeta influences the development and progression of spontaneous cancers," the researchers explained.

This work was supported by a grant from the National Cancer Institute, National Institutes of Health to Dr. Wood. In addition to Drs. Wittschieben and Wood, others involved in this study include Shalini C. Reshmi, Ph.D., and Susan M. Gollin, Ph.D., University of Pittsburgh Graduate School of Public Health.

'"/>




Page: 1 2 3

Related medicine news :

1. Little sleep as bad as no sleep
2. Aspirin Induced Asthma , A Little-Known Inducer
3. A Little Weight Loss Found To Make A Significant Difference In Men
4. Little Clinic LLC Plans Super Medical Clinics in Publix Super Markets
5. Trendsetters: Little girls fast track into ladies even before they know it
6. The Little Known Facts of Junk DNA
7. Too Much Or Little Sleep Increases Risk Of Diabetes
8. Diabetes Risk Pronounced With Too Much or Too Little Sleep
9. Reverse Heart Transplant Surgery On A Little Girl Makes History
10. Most People With Arthritis Do Little Or No Exercise At All
11. Little Makoda-Poster Girl For Leukemia Awareness Campaign Losses Her Battle Of Life
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Little Known DNA Repair Enzyme May Tumor Suppressor Gene

(Date:7/23/2014)... experts have joined together for the first time to ... millions of people worldwide suffering from the condition. , ... cause irreversible joint damage if left untreated. , PsA ... which causes a red, scaly rash, and affects approximately ... , Around one in five go on to develop ...
(Date:7/23/2014)... new study in East Asian women has identified three ... cancer. The research, led by Vanderbilt University investigators, was ... , While breast cancer is one of the most ... genetic risk factors for the disease have focused on ... genetic heritage and environmental exposures between East Asian women ...
(Date:7/23/2014)... 2014 On July 21, 2014, My Positive ... Jack Tracey for an episode that spoke about the group ... asks Tracey to talk some about the formation of the ... mission, it was started right here in Charleston, originally it ... to help survivors of sexual abuse. Their purpose has shifted ...
(Date:7/23/2014)... 23, 2014 The Circuelle Foundation ... academic institutions uncovering the importance of breast self-exams ... need for breast self-exams is contradictory and can ... today for keeping this healthy ritual. , “Women ... the significance of breast self-exams and becoming breast ...
(Date:7/23/2014)... Psoriasis is an autoimmune disease that ... the skin—but this disease is not just skin deep. ... some cancers, certain types of arthritis, or ulcerative colitis. ... it occurs in families and is not contagious. It ... symptoms must be managed at all times to relieve ...
Breaking Medicine News(10 mins):Health News:Psoriatic arthritis patients need better screening, warns panel of experts 2Health News:Vanderbilt-led study identifies genes linked to breast cancer in East Asian women 2Health News:My Positive Perspective Airs Episode to Raise Attention to the Group Darkness to Light 2Health News:Historical and Current Research Points to Importance of Breast Self-Exams 2Health News:MedicationDiscountCard.com Makes Tazorac Discount Cards For Psoriasis Sufferers 2
... and SAN JOSE, Calif., March 31 ... today announced that it has entered into a contract ... embedded computing engine for Authentidate,s joint ... initial delivery of units, Authentidate will have the option ...
... in incremental Medicare spending in FY 2006ATLANTA, March ... in-hospital mortality and some complications among Medicare beneficiaries ... time, rates of infection and acute respiratory distress ... surgery increased. Those were among the findings of ...
... Key Step in Ongoing Research to Replicate Insulin-Producing Function ... , SANTA BARBARA, Calif., March 31 A ... pancreas for patients with diabetes has been achieved, according ... Diabetes Technology & Therapeutics .Researchers at the ...
... patient safety, says Dr. FriedbergCORONA DEL MAR, Calif., ... (ASA) April ,Anesthesiology, reports of 2,211 patient deaths ... ,TOO MUCH, anesthesia)," says Dr. Friedberg. "Had the ... (BAMs), FDA approved and available since 1996, many, ...
... Trusted Name in Home Health Care Provides Extensive Services ... and most experienced provider of in home support and ... its San Francisco location. Interim HomeStyle Services first ... non-medical home care services to help people remain independent ...
... Dr. Andrew Cheng, ENT, Offers Help to Tinnitus Sufferers , ... Edison, NJ (PRWEB) March ... which there is no cure. In fact, an estimated 50 million people (according ... in the ears) that ranges from mild to severe - so severe ...
Cached Medicine News:Health News:Eurotech and Authentidate Enter into a Contract for Embedded Computer for Home-Based Medical Device 2Health News:Eurotech and Authentidate Enter into a Contract for Embedded Computer for Home-Based Medical Device 3Health News:Number of Revascularization Procedures, Related In-Hospital Mortality and Some Complications Decline, While Rates of Infection and Acute Respiratory Distress Syndrome (ARDS) Following Coronary Artery Bypass Graft (CABG) Surgery Increase 2Health News:Number of Revascularization Procedures, Related In-Hospital Mortality and Some Complications Decline, While Rates of Infection and Acute Respiratory Distress Syndrome (ARDS) Following Coronary Artery Bypass Graft (CABG) Surgery Increase 3Health News:Researchers Successfully Create Computer-Simulated Model for Evaluating Artificial Pancreas 2Health News:Researchers Successfully Create Computer-Simulated Model for Evaluating Artificial Pancreas 3Health News:American Society of Anesthesiologists - 2,211 Patient Deaths From OVER Medication 2Health News:Nation's Largest Home Care Provider Welcomes New Management Team to San Francisco Office 2Health News:Ear Health News: Natural Treatments to Ease Tinnitus Intensity 2
(Date:7/23/2014)... , July 23, 2014 PositiveID ... Fla. , is an emerging player in ... systems for bio-threat detection and rapid medical testing. ... M-BAND (Microfluidic Bio-agent Autonomous Networked Detector), was developed ... Security ("DHS") Science & Technology directorate, and $30 ...
(Date:7/23/2014)... , July 23, 2014  When it comes to ... is ready to roll out the red carpet. ... an influx of HAL 9000-like robots into our human sphere. ... now, there,s a pressing need to apply new technologies to ... worldwide market for medical robotics is expected to increase from ...
(Date:7/23/2014)... South Korea , July 23, 2014  Mezzion ... clinical program to evaluate the use of udenafil to ... for single ventricle heart defects. The clinical program will ... representatives of the Pediatric Heart Network (PHN), a multi-center ... and Blood Institute (NHLBI) of the National Institutes of ...
Breaking Medicine Technology:PositiveID Analyst Inspection: Emerging Contender in BioThreat Detection - First Ever Revenue Guidance and Backlog Position Company for Increased Visibility and Traction - by SmallCapTraders.com 2Mezzion Pharma Initiates Clinical Development Program To Evaluate Udenafil In Adolescents With Single Ventricle Heart Defects 2
... Feb. 23, 2011 Colorcon, Inc., today announced ... product line to include PVA-based, high-productivity systems designed ... the EU. European Commission Directive ... use of existing additives in certain food supplement ...
... SAN DIEGO, Feb. 23, 2011 Thomas, McNerney & ... invests in life science and medical technology companies, will ... to San Diego.  Thomas, McNerney partner Pratik Shah, Ph.D. ... being held in San Diego. "Southern California ...
Cached Medicine Technology:Thomas, McNerney & Partners Expands Team and Moves West Coast Office to San Diego 2
... wound filler and Tegagel hydrogel wound ... dressings specially formulated to help provide ... shown to enhance wound healing. The ... needs for management of non-draining, minimally ...
... complete physician preference card system as well ... all the supply management requirements of the ... combined with a broad array of inventory ... and operating suite supply and charge capture ...
... ErecAid® Esteem™ External Vacuum Therapy System restores ... impotent men. Non-invasive and low cost vacuum ... of desirable outcome", makes it the ideal ... Vacuum Therapy System causes penile rigidity that ...
Easy to Use manual vacuum system features a pumping mechanism that can be operated with one hand....
Medicine Products: