Navigation Links
Lithium May help in Alzheimer's Disease

Alzheimer's affects about 12 million people worldwide. Lithium may have a potential role in treating Alzheimer's. Lithium targets an enzyme called GSK-3 that facilitates the modification of both the proteins found in Alzheimer's patients. Identification of GSK-3 as a target could help in developing other drugs that disrupt the production of both proteins.

Another advantage to lithium is that it does not disrupt the processing of another protein called notch, as do other potential Alzheimer's drugs. Notch is vital for the production of blood cells.
The drug has been used for decades to treat manic depression. //Alzheimer's is marked by the buildup in the brain of one protein, called amyloid beta, outside nerve cells and a second, called tau, that forms tangles in the cells. Many scientists believe that the accumulation of amyloid beta causes the debilitating effects of the memory-robbing disease.

The recent issue of the journal Nature has reported that in mice experiments, Lithium blocks the production of proteins that form deposits in the brains of Alzheimer's patients. Lithium, though widely used to treat mental problems does have many side effects, including kidney damage.
"Potentially, lithium could be used to reverse both the pathological features of Alzheimer's disease," said Dr. Peter Klein of the University of Pennsylvania who co-authored the current study. "It seems you could block with a single medicine both of the major structural manifestations of the disease. This would be the first time that has been shown," said Dr. Sam Gandy, director of the Farber Institute for Neurosciences at Thomas Jefferson University in Philadelphia.

Klein and his colleagues overproduce a protein that when modified forms amyloid beta in mice. The mouse experiments showed that lithium disrupts that modification process. They also showed that lithium disrupts the modification of tau. Currently it is unclear what role tau plays i n cellsin the progression of Alzheimer's.

Alzheimer's disease usualy starts at the age of 60 years and involves the parts of the brain that control thought, memory, and language. At present we do not know what causes Alzheimer's and there is no cure.
'"/>




Related medicine news :

1. High Doses of Lithium-Like Drugs May Impair Neuronal Function
2. Lithium Increases Gray Matter in Bipolar Brains
3. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
4. Decrease in testosterone levels lead to Alzheimers
5. Smokers are prone to Alzheimers
6. Over-The-Counter Drugs May Prevent Alzheimers
7. Alzheimers followed by head injury
8. Vitamin E useful for Alzheimers
9. Staying mentally energitic prevents Alzheimers
10. Researchers trick Alzheimers Enzyme
11. Drug Offers Hope for Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/4/2016)... (PRWEB) , ... December 04, 2016 , ... Are You ... of the most certified and experienced Indoor Air Quality Companies in VA, MD and ... Remediation Regulations. , The new mold law in the district of Columbia ...
(Date:12/2/2016)... ... , ... Two years ago, Arizona State University students produced ... 1 million viewers and won numerous honors, including the region’s top Emmy and ... Cronkite School of Journalism and Mass Communication are following up their award-winning investigation ...
(Date:12/2/2016)... ... , ... Advanced Inc., a leading provider of travel therapy and travel nursing ... as Advanced Inc.’s Chief Financial Officer, effective December 1, 2016. Jason previously served as ... operational leadership experience to Advanced Inc. He began his career in finance at Ernst ...
(Date:12/2/2016)... ... December 02, 2016 , ... U.S. Surgeon General, Dr. Vivek ... Dr. Murthy explains how he was inspired to practice medicine at an early age ... is about more than making diagnoses and prescribing medicine,” he states. “It is about ...
(Date:12/2/2016)... ... ... More than half of American teens report losing their virginity before they ... child about sex related topics, less than 60 percent spoke about deeper themes like ... launch of its second edition of the “Sexual Wellness” campaign, aiming to address the ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... -- Quantum Radiology,s Mobile Breast Center (QR MBC) brings ... women at the workplace, thereby maximizing convenience and compliance.  ... Lines and SunTrust Bank, and community health groups to ... initiatives. "I think it,s a great service ... have a mammogram without taking a large amount of ...
(Date:12/2/2016)... On Thursday, December 1st 2016, ... research, development and innovation in the biopharmaceutical industry at ... in the presence of Sergey Tsyb, Vice Minister of ... , Natalia Sanina, First Vice Chairman of the ... of Roszdravnadzor, National Service of Control in Healthcare, Sergey ...
(Date:12/2/2016)... 2, 2016  Maxor National Pharmacy Services, LLC ("Maxor"), today ... Inc. ("PSI").  The combination of Texas -based ... -based PSI bring together both company,s clinical expertise and high-touch ... an industry-leading specialty pharmacy. About Maxor ... , , ...
Breaking Medicine Technology: