Navigation Links
Lithium May help in Alzheimer's Disease

Alzheimer's affects about 12 million people worldwide. Lithium may have a potential role in treating Alzheimer's. Lithium targets an enzyme called GSK-3 that facilitates the modification of both the proteins found in Alzheimer's patients. Identification of GSK-3 as a target could help in developing other drugs that disrupt the production of both proteins.

Another advantage to lithium is that it does not disrupt the processing of another protein called notch, as do other potential Alzheimer's drugs. Notch is vital for the production of blood cells.
The drug has been used for decades to treat manic depression. //Alzheimer's is marked by the buildup in the brain of one protein, called amyloid beta, outside nerve cells and a second, called tau, that forms tangles in the cells. Many scientists believe that the accumulation of amyloid beta causes the debilitating effects of the memory-robbing disease.

The recent issue of the journal Nature has reported that in mice experiments, Lithium blocks the production of proteins that form deposits in the brains of Alzheimer's patients. Lithium, though widely used to treat mental problems does have many side effects, including kidney damage.
"Potentially, lithium could be used to reverse both the pathological features of Alzheimer's disease," said Dr. Peter Klein of the University of Pennsylvania who co-authored the current study. "It seems you could block with a single medicine both of the major structural manifestations of the disease. This would be the first time that has been shown," said Dr. Sam Gandy, director of the Farber Institute for Neurosciences at Thomas Jefferson University in Philadelphia.

Klein and his colleagues overproduce a protein that when modified forms amyloid beta in mice. The mouse experiments showed that lithium disrupts that modification process. They also showed that lithium disrupts the modification of tau. Currently it is unclear what role tau plays i n cellsin the progression of Alzheimer's.

Alzheimer's disease usualy starts at the age of 60 years and involves the parts of the brain that control thought, memory, and language. At present we do not know what causes Alzheimer's and there is no cure.
'"/>




Related medicine news :

1. High Doses of Lithium-Like Drugs May Impair Neuronal Function
2. Lithium Increases Gray Matter in Bipolar Brains
3. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
4. Decrease in testosterone levels lead to Alzheimers
5. Smokers are prone to Alzheimers
6. Over-The-Counter Drugs May Prevent Alzheimers
7. Alzheimers followed by head injury
8. Vitamin E useful for Alzheimers
9. Staying mentally energitic prevents Alzheimers
10. Researchers trick Alzheimers Enzyme
11. Drug Offers Hope for Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... ... ... Leading pediatric oncology experts at Children’s National Health System will join ... International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by Jeffrey Dome, ... at Children’s National, and Stephen P. Hunger, M.D., Chief of the Division of ...
(Date:10/12/2017)... ... October 12, 2017 , ... Women-owned and Grand Rapids-based workplace ... Brightest in Wellness® by Best and Brightest. OnSite Wellness will be honored at ... from 7:30 a.m. to 2 p.m. at the Henry Autograph Collection Hotel, located ...
(Date:10/12/2017)... ... , ... In the United States, single-family home owners pay ... York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, and California—the average is $7,000 a ... rates, which contributes to the relatively lower cost of living in places like ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... Dining at the University of California Berkeley, and other leading institutions in announcing ... buying power of institutions to change the way animals are raised for food. ...
(Date:10/12/2017)... San Antonio, Texas (PRWEB) , ... October 12, ... ... medical device and biologics manufacturer, has expanded its executive staff with the addition ... Development. , In this role, Slott will develop the national distribution and sales ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Lilly and Company (NYSE: LLY ) will ... 2017 on Tuesday, October 24, 2017. Lilly will also ... investment community and media to further detail the company,s ... at 9 a.m. Eastern time. Investors, media and the ... conference call through a link that will be posted ...
(Date:9/28/2017)... Hill-Rom Holdings, Inc. (NYSE: HRC), will host ... webcast on Friday, November 3, 2017, beginning at 7:00 ... approximately 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... performance and guidance for 2018, Hill-Rom executives will also ... performance, and long-range financial outlook through 2020. ...
(Date:9/25/2017)... AMSTERDAM , Sept. 25, 2017   ... Trial Master File solutions, today—from the IQPC Trial ... Amsterdam , NL)—announced that EastHORN Clinical Services ... its clinical programs and TMF management. EastHORN, a ... Montrium,s eTMF platform to increase transparency to enable ...
Breaking Medicine Technology: