Navigation Links
LipB Protein Inhibitors Help To Fight Against TB

According to a recent study conducted by the researchers at the Hamburg Outstation of the European Molecular Biology Laboratory (EMBL) and the Max Planck Institute for //Infection Biology (MPIIB) has found the structural image of a protein needed for the TB bacteria to survive which could be targeted by the drug companies. Tuberculosis is one of the deadliest and the oldest disease. It is caused by the microorganism Mycobacterium tuberculosis. It affects about one third of the world's population. Some of the bacterial strains have developed resistance to drugs.

The study results are published in the Proceedings of the National Academy of Sciences (PNAS). Matthias Wilmanns, Head of EMBL Hamburg reveals the dangerousness and persistence of the bacteria M. tuberculosis. The functions of tuberculosis proteins and their atomic structures are investigated to develop inhibitors against the proteins. It was found that a protein, LipB is necessary as it activates cellular machines that drive the bacterium's metabolism. Stefan Kaufmann's department at the MPIIB has found that a 70 fold increase in LipB in patients infected by multidrug-resistant forms of M. tuberculosis.

Hence it plays a key role in the development of various new drug targets. A structural picture of the protein in the form of a technical diagram is being built which is of great importance. Qingjun Ma from Wilmann's group used high-energy synchrotron radiation beamlines and created an atom-by-atom map of the protein's structure. With the help of the high-resolution picture it was found how LipB attaches specific fatty acids onto other proteins. Wilmanns said that LipB is a very promising drug target as M. tuberculosis has no backup mechanism that could take over LipB's role. The scientists are now searching for drugs that inhibit the active site and prevent the bacterium ability to survive and replicate.


'"/>




Page: 1

Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
3. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase
4. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese
5. Protein in urine foresees heart disease
6. Levels Of Blood Proteins May Help Heart Disease Care
7. Protein signals need for heart surgery
8. Protein and fat improve memory
9. Clotting Protein plays a role in nerve repair
10. High Levels of Protein Linked to Brain Shrinkage
11. Protein can change worn muscle fibres
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/26/2017)... ... 26, 2017 , ... Journal of Oral Implantology – Tooth loss ... overall dental health, including complications with speech, eating, and overcompensation of mouth due to ... lost teeth. As the number of tooth replacements increase, it is imperative to design ...
(Date:4/26/2017)... ... April 26, 2017 , ... Elisabete Miranda, president and CEO ... Enterprising Women magazine as one of its 2017 Enterprising Women of the Year, ... have demonstrated that they have fast-growth businesses, mentor or actively support other women ...
(Date:4/26/2017)... ... April 26, 2017 , ... RawTrition now brings you ... to get nutrients from SUPERFOODS! , RawTrition is taking nutrients to the ... level because the body recognizes its raw form (unlike the synthetically made options that ...
(Date:4/26/2017)... FL (PRWEB) , ... April 26, 2017 , ... ... and human performance, is proud to announce that it has received 510(k) clearance ... technologies, the MyoCycle Home and the MyoCycle Pro. , Both devices are stationary ...
(Date:4/25/2017)... ... 25, 2017 , ... Coalition Duchenne, a ... muscular dystrophy, and funding for Duchenne research, congratulates Capricor Therapeutics on positive ... trial in Duchenne announced today. , Coalition Duchenne funded studies carried out ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... , April 19, 2017 Cardiology devices segment ... projected period The Cardiology Devices segment is likely ... US$ 15 Mn in 2018 over 2017. By the end ... market valuation close to US$ 700 Mn, expanding at a ... segment dominated the Asia Pacific reprocessed ...
(Date:4/19/2017)... , April 19, 2017  Vanderbilt University Medical ... patients in Nashville , Tennesse have ... Esophageal Sphincter Stimulation for GERD (LESS GERD) trial. The ... provide long-term reflux control by restoring normal function to ... 65 million people in the United States ...
(Date:4/19/2017)... HANOVER, N.J. , April 19, 2017 /PRNewswire/ ... conducted by the National Heart, Lung, and Blood ... (NIH) demonstrating that 58% of patients with treatment-naïve ... six months when treated with eltrombopag at the ... 1 . The study evaluated three sequential treatment ...
Breaking Medicine Technology: