Navigation Links
Link Between Immune System And Nervous System

Researchers have found a link between the signaling pathways in the immune cells that seem to point to a firm connection between the immune and the nervous system.// This new research could be important in uncovering for a potential HIV treatment that could effectively deny the virus entry into the cells.

The cell culture study by a research team from The Children's Hospital of Philadelphia and the University of Pennsylvania appears in the Proceedings of the National Academy of Sciences, published online on May 4.

The team, led by Steven D. Douglas, M.D., chief of the Section of Immunology at The Children's Hospital of Philadelphia, analyzed neurokinin-1 receptors found on the surfaces of monocytes, immune cells that develop into macrophages. The neurokinin-1 receptors (NK-1R) are docking sites for substance P, a well-known neurotransmitter that plays important roles in both immune function and the nervous system.

In the current study, the Douglas team investigated two forms of NK-1R in a human monocyte/macrophage cell line. One was a full-length receptor, the other a shortened version with fewer amino acids. When the researchers added substance P to cell cultures with the receptors, both responded with an increase in calcium ions, but used distinct signaling pathways.

The truncated NK-IR did not respond directly to substance P, but worked through another signaling molecule, the chemokine RANTES, to increase the calcium flow. The RANTES molecule is important because it binds to another cell receptor, CCR5, which is crucial in allowing common strains of HIV (R5 strains) to infect immune cells.

Significantly, when the investigators added the drug aprepitant, which binds to NK-1R, to their cell cultures, it inhibited signaling from both the full-length and short form of the receptors.

Although the current study was not focused on HIV infection, it directly relates to broader interests of Dr. Douglas' laboratory. He currently leads a four-year program project grant from the National Institute of Mental Health, entitled, "Neurokinin-1R (Substance P Receptor) Antagonists for HIV Therapy." One project within that grant will conduct a phase 1 (safety) trial of aprepitant in adults with HIV infection. Currently used as an anti-nausea medication, aprepitant, which has the trade name Emend, might also block HIV infection.

Because macrophages are a reservoir for HIV, a strategy that denies the virus entry into those immune cells may be important in combating HIV infection. Dr. Douglas showed in 2001 that another NK-1R antagonist blocked HIV replication within macrophages in cell culture. The hope is that aprepitant may show a similar protective effect in patients.

"We postulate that blocking NK-1R may send signals to turn off the CCR5 receptor for HIV, closing the door to the virus," said Dr. Douglas. "Underlying the signaling mechanisms are the questions, 'how does the immune system talk to the nervous system?' and 'how does the nervous system talk back?' Substance P is a link between both systems, and this study increases our understanding of those underlying questions." Source: Eurekalert
'"/>




Related medicine news :

1. Link Between Infection And Heart Disease
2. Prescription Drug Use Varies Widely Between States
3. Wait Between Pregnancies
4. Link Between Migraines and Behavioral Disorders
5. Link Between Obesity and Behavior in Kids
6. Link Between Mothers Depression and Violence in Children
7. Link Between Alcohol and Decrease in Brain Size
8. Link Between Musculoskeletal Pain and Vitamin D Deficiency
9. Link Between Hyperglycemia & Hospital Mortality
10. Link Between Alcohol Consumption And Cardiovascular Disease
11. Understanding The Link Between Hormone Replacement and Respiratory Disease
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/12/2016)... ... ... CDRH Enforcement Trends: , Back to the Future , Feb. 25, 2016 — 11:00 a.m. ... “Those who don’t learn from history are doomed to repeat it.” , An analysis of ... year. But that takes time. , Take a close look at the warning letters ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... ... firm announced that nominations have closed for the ISE Southeast Awards 2016. Finalists ... be announced at the ISE® Southeast Executive Forum and Awards Gala on March ...
(Date:2/12/2016)... ... February 12, 2016 , ... AssureVest Insurance Group, a ... initiating a charity drive that will raise funds earmarked to purchase computers and software ... Elementary School. , “My school is in a low-income area and has more than ...
(Date:2/12/2016)... ... 12, 2016 , ... Donor Network West, the organ procurement organization that heals ... with San Ramon Regional Medical Center. Under the collaboration, the first of its kind, ... accommodate a more certain time frame for donor families for the recovery of organs. ...
(Date:2/12/2016)... ... 12, 2016 , ... Nearly every health website and vision ... articles generally list between five and 15 foods that should be consumed regularly ... of these lists and believes that nutritious eye healthy foods are extremely important, ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... , Ungarn, February 12, 2016 /PRNewswire/ ... Medizintechnikunternehmen, das sich auf den ungedeckten medizinischen ... heute positive Ergebnisse seines klinischen Forschungsprogramms bekannt. ... Asthma-Patienten beschäftigt, ergab Verbesserungen ihrer respiratorischen Funktionen ... Indiso ltd , ein Medizintechnikunternehmen, das sich ...
(Date:2/11/2016)... 11, 2016 Stem cells are primitive cells ... self-renewal and the capacity to differentiate into mature cell ... as the first mouse embryonic stem cells were derived ... 1995 that the first culturing of embryonic stem cells ... not produced until 2006 As a result of these ...
(Date:2/11/2016)... , Feb. 11, 2016  Walgreens has committed ... 39 states and Washington, D.C. as ... move that was commended by shareholder advocacy organization As You ... As You Sow. "Many people hold on to unneeded drugs ... can have tragic consequences." --> Conrad MacKerron ...
Breaking Medicine Technology: