Navigation Links
Link Between Huntington’s and Abnormal Cholesterol Levels in Brain Establishe

Mayo Clinic researchers have discovered a protein interaction that may explain how the deadly Huntington’s disease affects the brain.// The findings, published in and featured on the cover of the current issue of Human Molecular Genetics, show how the mutated Huntington’s protein interacts with another protein to cause dramatic accumulation of cholesterol in the brain.

“Cholesterol is essential for promoting the connection network among brain cells and in maintaining their membrane integrity. Both the level of cholesterol and its delivery to the proper locations in the cell are essential for the survival of neurons,” explains Mayo Clinic molecular biologist Cynthia McMurrary, Ph.D.

“Our discovery that the mutant Huntington’s disease protein derails the cholesterol delivery system and causes cholesterol accumulation in neurons provides us with key results and solid clues to the mechanism of this disease,” says Dr. McMurray. “Fully understanding the mechanism of toxicity is the key to developing treatments.”

Huntington’s disease -- sometimes called Huntington’s chorea or St. Vitus’ dance -- is a progressive, degenerative condition that causes nerve cells in the brain to waste away. Symptoms include uncontrolled movements, emotional disturbances and mental deterioration.

The mutant protein of Huntington’s attacks the railroad system of brain cells and impairs transport of essential materials required for neurons to function. When this transportation system goes awry in the parts of the brain affected in Huntington’s disease, motor skills, cognitive skills and even speech can be affected. A person cannot move without shaking, and physical control gradually deteriorates, often with accompanying personality changes, depression and increased risk of suicide. Those who have Huntington’s commonly die from complications of the disease, such as falls or infections.

Approximately 30,000 Americans have Huntington’s dis ease. Another 150,000 carry the gene and have a 50 percent risk of passing it on to their children. The disease is easily diagnosed by a blood test, but symptoms usually don’t appear until middle age.

Significance of the Research

Their findings, say the researchers, provide the first direct link between the Huntington’s protein and the protein that controls capture and trafficking inside the cell. Their research suggests a possible means by which Huntington’s disease functions.

Because no one knows how the disease is incurred or spreads, this new information is critical and establishes a clear path for investigations to move forward.

The Mayo researchers observed the abnormal accumulation of cholesterol in cultured neuronal cells in the laboratory and in the brains of animal models. They found that this happens only when the mutant Huntington’s protein is expressed together with the molecule, caveolin-1. Caveolin-1 is the major structural protein of small vesicles called caveolae, which capture cholesterol and move it in and out of the neuronal membranes. When the researchers “knocked out” expression of caveolin, the neurons expressing mutant Huntington’s protein stopped accumulating cholesterol.

ource-Newswise
SRM
'"/>




Related medicine news :

1. Link Between Infection And Heart Disease
2. Prescription Drug Use Varies Widely Between States
3. Wait Between Pregnancies
4. Link Between Migraines and Behavioral Disorders
5. Link Between Obesity and Behavior in Kids
6. Link Between Mothers Depression and Violence in Children
7. Link Between Alcohol and Decrease in Brain Size
8. Link Between Musculoskeletal Pain and Vitamin D Deficiency
9. Link Between Hyperglycemia & Hospital Mortality
10. Link Between Alcohol Consumption And Cardiovascular Disease
11. Understanding The Link Between Hormone Replacement and Respiratory Disease
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/19/2017)... NJ (PRWEB) , ... January 19, 2017 , ... ... locally owned insurance agency which serves Lawrenceville, New Jersey and the surrounding area, ... , Amyotrophic lateral sclerosis (ALS), more commonly known as Lou Gehrig's disease ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... 2017 Spring Create Real Impact contest from Impact Teen Drivers and California Casualty. ... http://www.createrealimpact.com . , Educational grants totaling $15,000 will be awarded for the ...
(Date:1/19/2017)... ... 2017 , ... Bill Howe Plumbing, Heating & Air in San Diego announces ... Healthy is Your Heart Drawing Contest The drawing contest asks children to draw ... Heating & Air receives over 600 entries. The culmination of the joint effort will ...
(Date:1/19/2017)... ... January 19, 2017 , ... Sales Focus Inc. (SFI), a Maryland-based ... US market. , Over the past 20 years SFI has been recognized as the ... launched six new clients into the US market. The new clients include: Panacea ...
(Date:1/19/2017)... ... January 19, 2017 , ... Each year, the ... a conference where hundreds of surgeons from over fifteen different countries come together ... cosmetic breast augmentation to breast reconstruction for breast cancer patients, teaching ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... -- ViewRay, Inc. (Nasdaq: VRAY) announced today that the German ... Germany , has purchased a MRIdian ... Clinic Heidelberg as part of its initiative for MRI-based ... be headed by Medical Director and Professor Jürgen Debus, ... German Cancer Research Center (DKFZ), the Heidelberg Heavy Ion ...
(Date:1/19/2017)... Jan. 19, 2017   Science Exchange , the ... announce that the first five replication studies from ... been published in eLife today. Despite intense scrutiny ... first practical evaluation of reproducibility rates that may ... Unlike other assessments of reproducibility, the results of ...
(Date:1/19/2017)... 19, 2017 New Review ... Address Motor Symptoms and Motor Complications in Mid- ... ... (Logo: http://photos.prnewswire.com/prnh/20151014/276718LOGO) C ... Neurological Review,2016;11(Suppl. 2): 2-15, http://www.touchneurology.com/articles/safinamide-new-therapeutic-option-address-motor-symptoms-and-motor-complications-mid-late ...
Breaking Medicine Technology: