Navigation Links
Link Between Hepatitis C And Liver Cancer Unraveled By Scientists

The exact mechanism by which Hepatitis C could cause liver cancers is has been very poorly understood in the previous years. Researchers from the University of Texas have now discovered a biochemical pathway// believed to play a key role in the association between liver cancer and Hepatitis C. The link or association is very similar to the already established link between the human papilloma virus (HPV), cervical cancer and genital warts.

“What we’ve found is that one of the hepatitis C virus proteins targets a cell protein that is crucial for suppressing the development of tumors, interfering with its ability to control cell proliferation. By knocking out this ‘tumor suppressor’ and promoting the proliferation of liver cells, this viral protein is setting up the liver for cancer”, according to Dr. Stanley M. Lemon, senior author of the paper.

Nearly 85% of liver cancers in the United States occur in Hepatitis C affected individuals. In addition, a more than 200 million people are believed to suffer from the chronic disease worldwide. In most of the cases, the sufferer is totally unaware of the infection. This facilitates widespread damage to the liver following the initial episode of infection. Under these circumstances, a liver transplant may be the only source of hope left for survival.

The currently available therapy with interferon represents the only effective treatment. This however is valuable only in 50% of the cases. In addition, it is also associated with a number of adverse effects. Failure to respond to therapy increases the chance of developing either cirrhosis or liver cancer.

Reduced quantities of the protein product of the retinoblastoma gene have been found in cells that harbor the Hepatitis C ‘replicon’. A replicon is nothing but a part of the genetic material of the hepatitis C virus that has the intrinsic property of self-replication and protein production. Experimental studies involving the replicons hav e enabled researchers identify a tumor suppressor protein, named NS5B. This protein has been found to play an important role in breakdown of the retinoblastoma gene by attaching to it. This molecular mechanism is very similar to the way HPV causes cancer growth.

The study has proved to be very valuable especially in the current scenario where no standard cure for Hepatitis C is present. Studies such as these could eventually pave way for the development of novel anti-viral treatments in the future. If hepatitis C were to be ‘cured’ effectively, it would mean the end of associated liver ancers.
'"/>




Related medicine news :

1. Link Between Infection And Heart Disease
2. Prescription Drug Use Varies Widely Between States
3. Wait Between Pregnancies
4. Link Between Migraines and Behavioral Disorders
5. Link Between Obesity and Behavior in Kids
6. Link Between Mothers Depression and Violence in Children
7. Link Between Alcohol and Decrease in Brain Size
8. Link Between Musculoskeletal Pain and Vitamin D Deficiency
9. Link Between Hyperglycemia & Hospital Mortality
10. Link Between Alcohol Consumption And Cardiovascular Disease
11. Understanding The Link Between Hormone Replacement and Respiratory Disease
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... , ... March 28, 2017 , ... ... physicians, Paul Yost, will begin serving as new board chair for Orange County ... Yost will serve the remainder of soon-to-be former chair Mark Refowitz’s term, which ...
(Date:3/28/2017)... ... 2017 , ... With less than 10,000 dermatologists in the United States and ... limited while the desire to conquer breakouts and eliminate skincare stress is widespread. ... online, today released its inaugural survey on the State of Acne in America. ...
(Date:3/28/2017)... Petersburg Florida (PRWEB) , ... March 28, 2017 , ... ... Marine Corp to raise money to for the Toys for Tots Literacy Campaign at ... federal budget in excess of $70 billion, the U.S. ranks at number 14 internationally ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... offered by the American Association of Integrative Medicine and available for application on ... at the AutismOne 2017 Conference in Colorado Springs. , Ed Arranga, president of ...
(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... ... Association’s Tri-State Camp Conference in Atlantic City March 13-16, was a busy spot ... team of professional staff discussed strategies for preventing outbreaks among camp communities during ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... SPRING, Md. , March 28, 2017 /PRNewswire-USNewswire/ ... approved Dupixent (dupilumab) injection to treat adults with ... patients whose eczema is not controlled adequately by ... are not advisable. Dupixent can be used with ... of Dupixent demonstrates our commitment to approving new ...
(Date:3/28/2017)... LONDON , March 28, 2017  "US ... insight on the various indicators and trend analysis ... generics drugs in mainstream pharmaceutical market in US. ... responsible for the growth on cancer generics drugs ... resulted in saving of billions of dollars for ...
(Date:3/28/2017)... PHOENIX , March 28, 2017  Today, Allergy ... released a new white paper to underscore the ... latex in healthcare. Specifically, there is substantial confusion as to ... FDA has urged manufacturers to drop the term "latex free" ... of the challenge to ensure a product is completely devoid ...
Breaking Medicine Technology: