( saliva and through contact with human ...)Link Between Family Size and Stomach Cancer Found,Health

saliva, and through contact with human feces. It has been estimated that half the people in the world carry the bacterium in their stomach.

Dr. Blaser is well known for his work with H. pylori. He and his longtime collaborator Guillermo Perez-Perez, DSc., Associate Professor of Medicine and Microbiology, who is also an author on the current study, have explored the bacterium's link to stomach cancer, elucidated genes associated with its virulence, particularly a gene called cagA, and provided evidence showing that the bacterium is mainly transmitted in families.

The current study involves a group of Japanese-American men who lived in Hawaii. These men were first evaluated in the 1960s as part of a heart disease study led by Dr. Abraham Nomura, who also is an author on the current study. The investigators had banked blood samples from 7,429 men who were examined between 1967 and 1975. In the following years, 261 of these men developed cancer.

The current study extends the follow-up of this group to 28 years, providing more reliable data to assess if family structure influenced the risk of cancer. Dr. Blaser and his colleagues, who published a study in the mid 1990s in The New England Journal of Medicine on the relationship between H. pylori and stomach cancer based on this Hawaii cohort, went back to the blood samples from the men who developed stomach cancer and tested the samples for antibodies to H. pylori and the cagA protein. Each of these men were matched with a similarly aged man from the original pool of men who didn't develop cancer.

The researchers assessed whether the risk of stomach cancer was associated with the number of siblings a man had and whether he was older or younger than his brothers and sisters. As in their previous study, they found that men who had cancer were three times more likely to carry H. pylori compared to age-matched men who didn't carry it. Those with cancer had large numbers of sibli
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