Navigation Links
Limiting sperm motility for contraception

An ion channel protein that plays a central role in sperm motility could be an enticing target for a new type of contraceptive that could be taken by either men or women to block the process of fertilization. The newly discovered protein, called CatSper, controls the flow of calcium into the tails of spermatozoa. This influx of calicum triggers the sperm’s motor proteins, causing the tail to beat.//

The CatSper ion channel is found only in a principal section of the sperm’s tail and nowhere else in the body, making it likely that a contraceptive that targets CatSper would have fat fewer side effects than a hormone-based contraceptive. Discovery of the CatSper ion channel was reported in an article published in the jouurnal Nature by Howard Hughes Medical Institute investigator David Clapham and colleagues at Harvard Medical School.

“It has been known that there are ion channels in sperm,” said Clapham. “But most of the ion channels studied before were associated with the sperm head.” According to Clapham these ion channels govern processes such as the sperm’s ability to dissolve the thick outer coating of the egg. Clapham and his colleagues were performing a general screen of the human gene database for novel calcium-selective ion channel genes when they discovered one with an unusual structure that resembled other channels known to play a role in cell motility.

Using antibody tracers, the researchers revealed that the gene - which they named CarSper, for “cation channel of sperm” - was expressed only in the testes and not in any other tissue.To begin to define the role of CatSper in sperm function, the researchers knocked out the gene in mice. They found that, although the mice were normal in every other respect, and that female mice were fertile, the male mice were completely infertile.

Studies of the sperm motility of the mice were then conducted by Gloria Perez and Janathan Tilly, co-authors of the Nature article, wh o found that the sperm from the knockout mice were less motile and showed less directed movement than normal sperm.To find out whether the sperm from the CatSper-knockout mice could still fertilize eggs, the researchers mixed the sperm with eggs whose outer covering, called the zona pellucida, had been removed. They found that the sperm could fertilize the eggs normally, and that the eggs began to develop normally.

“So, the only thing that seems to be wrong in the sperm of these mice is their inability to penetrate the zona pellucida,” said Clapham. “While this is a bit speculative, it might be that this channel is involved in giving sperm’s tail beating a kind of turbo-charge at the last instant, when it needs more power to penetrate the zona pellucida.”Clapham said that a contraceptive based on compounds to block the CatSper channel might have considerable advantages over hormonal contraceptives.

“Hormonal contraceptives have to be taken daily throughout a woman’s fertile life,” he said. Also, they have potential side effects, such as increased risk of blood clotting and cancer.”“If a drug could be designed to block this channel specifically, it could be taken by men or women. And, it would not have to be taken for a very long period to block fertilization, perhaps only just before or after intercourse,” he said.Clapham also pointed out that some forms of male sterility, such as those caused by lack of sperm motility, might be due to defects in the CatSper on channel.


'"/>




Related medicine news :

1. Limiting Infants Exposure To Smoke At Home
2. Limiting milk can hamper Babies’ Growt
3. Shapely sperm-a valuable indicator of fertility
4. Mutant sperm beat out healthy brethren in study
5. Stem cells grown into sperm cells
6. Gay men cannot donate sperm
7. SEMEN – More than just a sperm carrie
8. Shortage of donors at sperm bank clinics
9. Common contraception
10. Men happy to take contraception
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... ... a crisis. Her son James, eight, was out of control. Prone to extreme mood shifts ... upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife ... and say he was going to kill them. If we were driving on the ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Living, is proud to recognize Dr. Barry M. Weintraub as a prominent plastic ... most beautiful women in the world, and the most handsome men, look naturally ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group (VCG) sponsors ... on June 20th at the Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, ... to helping service members that have been wounded in battle and their families. Venture ...
(Date:6/24/2016)... ... 24, 2016 , ... To succeed under value-based payments, healthcare ... unsure how to move forward, given the need to sustain current operations. PYA ... to an organization’s specific needs. , PYA Principal Martie Ross states, “Healthcare providers ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Research and Markets has announced the addition ... - Forecast to 2022" report to their offering. ... to date financial data derived from varied research sources to ... potential impact on the market during the next five years, ... of sub markets, regional and country level analysis. The report ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... their offering. The current ... environment for MedImmune to enter. The US ageing population creates ... drive considerable growth for effective anti-influenza medications. The introduction of ... but development is still in its infancy. ...
(Date:6/23/2016)... , , , WHEN: ... , , , , LOCATION: , , , Online, with ... , EXPERT PANELISTS:  , , , Frost & Sullivan,s Global Vice ... Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager , ... industry is witnessing an exceptional era. Several new demand spaces, such ...
Breaking Medicine Technology: