Navigation Links
Life Functions Governed by Circadian Rhythms-new Research

In a new study conducted by Colorado State University shows that circadian rhythms dominate all life function. The functions of all the genes in the mammals are according to this daily rhythm. It disproves the prior theory that only 10 to 15% of genes were affected by the natures clock. It was earlier believed that some special function of the genes was the basic property of the organism. But these conclusion are refuted by the new study.The new study emphasises oscillation as a basic property of all genes in the organism. Daily life functions and metabolism are dominated by the circadian rhythm, thus regulating behaviour pattern of living.

Knowing about oscillation properties of genes involved in metabolism is essential for understanding how genes interact with and regulate health and disease. Colorado State University researcher Andrey Ptitsyn's new analysis of data collected through several studies establishes a baseline oscillation in 98 to 99 percent of all genes through advanced computer algorithms. Most of these genes have never been previously reported as changing their expression level in a daily cycle. Some of these genes, considered "housekeeping," have been used as a stable reference platform in gene expression studies.

"Anyone who diets, for example, knows you shouldn't eat late, and now we are getting closer to understanding why exactly," said Ptitsyn, a researcher in the Bioinformatics Center at the College of Veterinary Medicine and Biomedical Sciences. The center is located in the Department of Microbiology, Immunology and Pathology. "We discovered that all genes have a significant change in pattern of activity -- or expression -- throughout the day. Every pathway of gene expression is affected by circadian rhythms, and the timing of the rhythms from each group of genes that are synchronized is important."

Ptitsyn also discovered alternative short and long copies of some genes oscillating in the opposite phase. These genes are essential components of leptin signaling system, responsible for the sensation of satiety after eating. The oscillating pattern varies in different organs and determines the effect of leptin on regulation of the energy balance. Better understanding gene oscillation may provide researchers with clues for developing ways to treat people who overeat because of impaired leptin signaling.

Circadian rhythms are biological rhythms that cycle over a period of about 24 hours and regulate timing for most physiological functions and behaviors such as sleeping, eating and activity. As a checks-and-balances procedure, Ptitsyn analyzed the sets of data with several mathematical approaches to achieve

the same results. The research also shows that gene oscillation is significantly more organized when mammals are exposed to regular periods of day and night. Oscillation can become chaotic in states of consistent lighting or lack of lighting, but it never stops.

Comparing the complex system in which the genes function to an AC power grid, Ptitsyn made the discovery by plotting the expression of 20,000 genes on a scale of frequency, or intensity, over a two day period and sorting them by phase or timing of oscillation. Where previous studies have failed, the Colorado State study uses advanced algorithms that have the capacity to identify patterns in such a large number of genes.

Ptitsyn discovered that gene activity oscillates in a "finely orchestrated" system and gene expression can be impacted by daylight and darkness -- or a lack of both. For example, while gene expression oscillates in mice exposed to a constant state of dim light or darkness, the groups of genes that typically oscillate together -- such as genes responsible for the function of an organ or a specific tissue -- are chaotic under this state and don't function as a group. Lack of orchestration can be easily confused with the lack of oscillation. T his makes the rhythm much harder to detect.

"It's like a conductor walking away from an orchestra during a performance; each musician continues to play, gradually going out of key with the others," said Ptitsyn. That is one likely reason why researchers previously missed the impact of circadian rhythm on all genes.

Depending upon environmental factors, groups of genes can function in a synchronized manner, shifting in time against each other and working in what resembles a domino effect.

However, very few genes are found to be oscillating in the same phases in different tissues or organs. In fact, only about 5 percent of all genes fall into the same phase or timing of peaks and valleys. Synchronization with the activity of the other genes and genes in different organs is a very important and highly specific part of gene function.

In addition, genes can oscillate with different amplitude -- the swing between the highest and the lowest point. Genes are expressed at very different levels, but most of them have the same relative change throughout the day. However, some genes show significant change in the amplitude in different organs or in response to a changing environment.

"When we standardize genes onto a common scale that measures levels of expression, we could not find a single gene that did not oscillate," Ptitsyn said.


'"/>




Related medicine news :

1. Regular Use Of Cocaine Can Impair Brain Functions
2. Heart Functions Being Redefined By Researchers
3. Anticancer Properties of Vitamin D Could Be Separated From Other Functions
4. A New study Throws Light On The Growth & Functions Of Insulin Producing Beta Cells
5. Triple Therapy Shows Better Improvement of Brain Functions
6. Loss of Functions Traced in Alzheimers disease
7. Ariel Sharon Moved out of ICU After Improvement in Kidney Functions
8. Lung Functions and Stroke
9. Dry Eye Syndrome Affects Visual Functions
10. Circadian Rhythm Could Determine Lung Function
11. Researchers Investigate Gene Linked With Circadian Liver Clock
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/2/2016)... WACO, Texas (PRWEB) , ... May 02, 2016 , ... ... Corporation will offer an incentive to people who share their fitness journey on ... footwear and premium first aid products, will award a $100 product voucher each week ...
(Date:5/2/2016)... New York, NY (PRWEB) , ... May 02, 2016 , ... ... Highlighting the year’s best in pet gear and toys, leading product review site ... TTPM Pets Paw of Excellence Awards at their Spring Showcase at the Metropolitan ...
(Date:5/2/2016)... Netherlands (PRWEB) , ... May 02, 2016 , ... Further ... honored to announce that the new WHIMZEES Variety Value Boxes were selected from over ... New Product Showcase Award. , WHIMZEES natural dental chews for dogs are a ...
(Date:5/2/2016)... Rafael, CA (PRWEB) , ... May 02, 2016 , ... The 2016 World Ultimate & ... Nike Ultimate Camp at Manhattan College, made the cut. The WUGC is being held in ... National Teams won the gold in the men’s division, another gold in the women’s masters ...
(Date:5/2/2016)... , ... May 02, 2016 , ... ... (AAC) event, will be held at the Bellagio Hotel in Las Vegas, NV ... Social Work (NASW) will be co-hosting the event. , This year’s conference will ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... 2016  Celsion Corporation (NASDAQ: CLSN ), ... from the first cohort of patients in its ... Study) combining GEN-1, the Company,s DNA-based immunotherapy, with ... newly-diagnosed patients with advanced ovarian cancer who will ... In the first three patients dosed, GEN-1 plus ...
(Date:4/29/2016)... , April 29, 2016 /PRNewswire/ ... Contamine, Directeur Financier Sanofi, ... santé, publie ses résultats pour le ... du Groupe, Jérôme Contamine, commente les ... et les perspectives pour le reste ...
(Date:4/28/2016)... -- Research and Markets has announced the ... 2016-2020" report to their offering.      ... global plastic surgery products market is expected to grow ... , ,The growing adoption of laser in aesthetics is ... market. Lasers are used to treat a broad range ...
Breaking Medicine Technology: