Navigation Links
Leukemia Drug Turns Mini-Molecules Up, Cancer Genes Down

that they are also important for normal differentiation.”

In this study, the researchers used leukemia cells grown in the laboratory and cells donated by patients to study how the drug ATRA affects miRNA levels and how those changes affect the cells.

The investigators exposed the leukemia cells to the drug for up to 96 hours, causing the cells to mature. The treatment increased the level of eight miRNAs and a drop in one compared with untreated cells.

Of these, the researchers focused on miRNA-15b and miRNA-16-1, which are known to regulate the activity of the Bcl-2 gene. They found that high levels of the two miRNAs were associated with low Bcl-2 activity.

Next, they showed that the two miRNAs actually caused the drop in Bcl-2 activity. They did this by adding additional amounts of the two miRNAs to leukemia cells not treated with ATRA. Restoring the miRNAs caused a strong drop in Bcl-2 levels.

The researchers then looked at miRNA let-7, a known regulator of the Ras oncogene, and likewise found that high levels of this miRNA were associated with low Ras activity.

They established a cause and effect relationship as before, by adding additional let-7 to untreated leukemia cells.

“Overall,” Garzon says, “our findings show that ATRA induces the expression of these three miRNAs, and through them regulates genes that need to be silenced for the cell to differentiate.”

Funding from the National Cancer Institute, the Paul and Mary Haas Chair in Genetics, a Lauri Strauss Discovery grant award, the Kimmel Foundation and the CLL Global Research Foundation supported this research.

Source-Bio-Bio Technoloy
SRM
'"/>




Page: 1 2

Related medicine news :

1. Cyclosporin A Treats Leukemia Complications
2. Leukemia pill shows promise against stomach cancer
3. Aspirin Lowers Leukemia Risk
4. Hope for Chemo-Resistant Leukemia Patients
5. Genes Found To Help Leukemia Treatment
6. Looking Towards More Effective Leukemia Treatment
7. Diet Found To Offer Protection Against Leukemia
8. Exposure To Night Light may Increase The Risk Of Leukemia
9. Skin Allergies Found To Increase The Risk Of Leukemia
10. Understanding Gene Profiles Could Help Cure A Resistant Form Of Leukemia In Kids
11. Night Light Found To Increase The Risk Of Leukemia
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Leukemia Drug Turns Mini Molecules Cancer Genes Down

(Date:3/27/2015)... CA (PRWEB) March 27, 2015 Endure ... Yoga for functional fitness athletes. This new program matches ... specific protocol for post-workout cool down. This program utilizes ... breath control and mental focus. , Karen Lefurgy, ... started practicing yoga long before I started Crossfit® training, ...
(Date:3/27/2015)... CA (PRWEB) March 27, 2015 SMI ... today announced it has launched the SM1120 MEMS based ... market. The microsensor profile at only 220um x ... maneuverability to reach challenging locations. With industry leading ... hour, the SM1120 provides a broad operating pressure range ...
(Date:3/27/2015)... Operatic contenders and their avid audience will be in ... acclaimed baritone Sherrill Milnes will be overseeing the grand ... Merion in Evanston. The event is the culmination of ... from around the country. “This is a highly-anticipated yearly ... in the country,” said Margaret Gergen, executive director of ...
(Date:3/27/2015)... (PRWEB) March 27, 2015 The ... Industry is a professional and in-depth study on ... market with a focus on the Chinese ... of the industry including definitions, classifications, applications and ... provided for both the international and Chinese domestic ...
(Date:3/27/2015)... (PRWEB) March 27, 2015 Smile Brands ... providers of business support services to dental groups in ... an affiliated Castle Dental office in Hendersonville, ... Hendersonville, TN 37075, this new Castle Dental office provides ... receive the latest in comprehensive, quality dental care. Hendersonville ...
Breaking Medicine News(10 mins):Health News:Endure Yoga Introduces WOD Recovery Yoga 2Health News:SMI Launches Catheter Mountable Pressure Sensor 2Health News:Opera Idol Competition At The Merion In Evanston 2Health News:Glutathione Industry International and China Market Analysis Report 2015-2020 2Health News:Glutathione Industry International and China Market Analysis Report 2015-2020 3Health News:Castle Dental® Opens Its First Dental Office in Hendersonville, TN 2Health News:Castle Dental® Opens Its First Dental Office in Hendersonville, TN 3
... Remain to Vote on the Proposed Merger, SOUTH SAN ... Dear VaxGen Stockholder, March 28th marks the date ... stockholder vote on the proposed VaxGen-Raven,merger. Your vote is important. ... votes cast in person or by proxy at the VaxGen ...
... March 20 Arthur J. Gallagher &,Co. ... Solutions, LLC,headquartered in Fort Washington, Pennsylvania. Terms ... in 2002, Healthcare Risk Solutions, LLC is ... insurance,products, associated risk mitigation consulting services and ...
... haze, scientists say , , THURSDAY, March 20 (HealthDay News) ... an important contributor to smog. , This chemical reaction ... dioxide (NO2) in "excited" states -- was long assumed ... University of California, San Diego, conclude that it,s actually ...
... Peake: Health Care Closer for Veterans, WASHINGTON, March ... access to world-class health care under,a Department of Veterans ... 2008. Secretary of Veterans Affairs Dr. James B. Peake ... Kentucky,Illinois, Indiana, Oklahoma, Tennessee and Washington., "VA is ...
... a proactive follow-up care program designed to help ... of life, PALO ALTO, Calif., March 20 ... it is offering oncology treatment,centers a way to provide ... quality of life. Varian is teaming with,Cogent Health Solutions ...
... people felt better dispersing gifts than buying things for themselves , , ... buy happiness, at least when you spend it on others. ... 21 issue of Science . It found that spending ... , What,s more, most people seemed unaware of this ...
Cached Medicine News:Health News:VaxGen Provides Updates and Encourages Stockholders to Vote In Favor of Proposed Merger With Raven 2Health News:VaxGen Provides Updates and Encourages Stockholders to Vote In Favor of Proposed Merger With Raven 3Health News:VaxGen Provides Updates and Encourages Stockholders to Vote In Favor of Proposed Merger With Raven 4Health News:VaxGen Provides Updates and Encourages Stockholders to Vote In Favor of Proposed Merger With Raven 5Health News:VaxGen Provides Updates and Encourages Stockholders to Vote In Favor of Proposed Merger With Raven 6Health News:VaxGen Provides Updates and Encourages Stockholders to Vote In Favor of Proposed Merger With Raven 7Health News:Smog's Origins Get Clearer 2Health News:VA to Open 14 New Clinics in Seven States 2Health News:Varian Medical Systems Teams With Cogent Health Solutions to Offer Case Management Software for Cancer Survivorship 2Health News:Varian Medical Systems Teams With Cogent Health Solutions to Offer Case Management Software for Cancer Survivorship 3Health News:Give and Be Happy 2
(Date:3/27/2015)... 27, 2015 XRpro Sciences, Inc., a ... and development services which features high throughput transporter ... announced financial results for the year ended December ... Chairman of XRpro Sciences commented, "We have completed ... development stage to commercial stage in large part ...
(Date:3/27/2015)... 27, 2015 According to a ... Catheter (Conventional, Advanced, Ultrasound), Ablation Catheter (Cryoablation, RF, Microwave), ... (AF, VT, WPW) - Global Forecasts to 2019 ", published ... reach around ~$4.73 Billion by 2019 with a CAGR ... 2019. Browse   90   ma ...
(Date:3/27/2015)... MARLBOROUGH, Mass. , March 27, 2015 ... ) and privately-held MirImmune LLC, today announced ... license agreement to RXi,s novel and proprietary ... cell-based cancer immunotherapies. The collaboration has the ... and patient friendly cancer treatments that could ...
Breaking Medicine Technology:XRpro Sciences Announces Fiscal 2014 Financial Results 2XRpro Sciences Announces Fiscal 2014 Financial Results 3XRpro Sciences Announces Fiscal 2014 Financial Results 4Electrophysiology (EP) Market Worth $4.73 Billion by 2019 2Electrophysiology (EP) Market Worth $4.73 Billion by 2019 3Electrophysiology (EP) Market Worth $4.73 Billion by 2019 4RXi Pharmaceuticals and MirImmune LLC Enter into an Exclusive Licensing Agreement for RXi's Self-Delivering RNAi (sd-rxRNA) Technology to Develop Cell-based Immunotherapies to Treat Cancer 2RXi Pharmaceuticals and MirImmune LLC Enter into an Exclusive Licensing Agreement for RXi's Self-Delivering RNAi (sd-rxRNA) Technology to Develop Cell-based Immunotherapies to Treat Cancer 3RXi Pharmaceuticals and MirImmune LLC Enter into an Exclusive Licensing Agreement for RXi's Self-Delivering RNAi (sd-rxRNA) Technology to Develop Cell-based Immunotherapies to Treat Cancer 4RXi Pharmaceuticals and MirImmune LLC Enter into an Exclusive Licensing Agreement for RXi's Self-Delivering RNAi (sd-rxRNA) Technology to Develop Cell-based Immunotherapies to Treat Cancer 5
... , NEW YORK, Dec. 2 ... available in its catalogue: , Electrodes for Medical ... http://www.reportlinker.com/p0164320/Electrodes-for-Medical-Devices---A-Global-Market-Perspective.html , Electrodes in electronic devices detect electrical ... created by chemical reactions. Medical application areas include blood ...
... , PALO ALTO, Calif., Dec. 2 ... 2009, Varian, Inc. filed with the U.S. Securities and Exchange Commission ... October 2, 2009. This Annual Report may be accessed through ... "SEC Filings," and then on "10-K" in the table shown. ...
Cached Medicine Technology:Reportlinker Adds Electrodes for Medical Devices - A Global Market Perspective 2Reportlinker Adds Electrodes for Medical Devices - A Global Market Perspective 3Reportlinker Adds Electrodes for Medical Devices - A Global Market Perspective 4Reportlinker Adds Electrodes for Medical Devices - A Global Market Perspective 5Reportlinker Adds Electrodes for Medical Devices - A Global Market Perspective 6Reportlinker Adds Electrodes for Medical Devices - A Global Market Perspective 7
... Optima MAX has the highest g-force ever. ... more than force. Optima MAX combines maximum ... achieve benchtop performance that's worlds apart from ... superior design, and enhanced efficiency, Optima takes ...
... generating 694,000 x g at ... Beckman Coulter's Optima L-90K Ultracentrifuge ... separations in less time. This ... a broad range of superb ...
... chemistry system brings versatility in a ... laboratory. A model of innovation and ... system features state-of-the-art Dimension technology, specifically ... in a flexible, affordable, easy-to-use system ...
... Dimension clinical chemistry integrated systems combine the ... cartridge, the power of the Multiply and ... the heterogeneous module to meet the challenges ... broad test menus, the systems can meet ...
Medicine Products: