Navigation Links
Leptin, The Next Generation Antidepressant?

A study conducted by Xin-Yun Lu, PhD and colleagues of the University of Texas Health Science Center found that Leptin when administered to the rat acts as an anti-depressant. Leptin is a hormone mainly given to people involved in weight regulation. //

The research was done on chronic unpredictable stress (CUS) rats. It was found that CUS rats had decreased levels of Leptin than the control rats. Hence this led to the idea that this hormone might play a significant role in assuaging depression symptoms in man. These findings were reported in the online Proceedings of the National Academy of Sciences.

The researchers say that there is very limited source on the data related to assuaging depression in humans using Leptin. For example in two studies it was proved that reduced Leptin plasma levels were seen in depressed patient an increased levels were found in patients undergoing Leptin anti-depressant therapies.

The researchers say that their finding are very useful because currently anti-depressant therapies are not of much use to the people because many of them do not respond to it.

They said that rats are the best animal models and especially CUS rats do not eat sucrose solution, which can be compared to the inability of man to enjoy his life (depression).

CUS rats don’t explore open space and give up easily in case of forced swimming test. It was found that they had lowered Leptin plasma levels and when retrained further for 30 minutes resulted in the further drop of Leptin levels. When these rats are injected with Leptin they have increased appetites for sucrose solution while the normal rats did no do so.

This study analyzed two sets of CUS rats one was administered Leptin (1mg/kg) other set was given Norpramin (desipramine), a medication used as an antidepressant in humans before the forced swimming test. It was found that 15mg/kg of Norpramin was comparable to 1.0 mg/kg of Leptin.

They a lso found that Intrahippocampal infusions of Leptin caused anti-depressant like effect in the forced swimming test. But on the other hand hypothalamus infusion of Leptin had no effect on forced swimming test. Then they came up with the notion that hippocampus is a brain is mediating Leptin's antidepressant-like activity.


'"/>




Related medicine news :

1. Hearing Problems Of Middle Age Are Affecting The Younger Generation
2. Tigecycline – New Generation Tetracycline With Broad Spectrum Antibacterial Activit
3. Newer Generation Sleeping Pills Lack Superior Performance
4. New Generation Clinical Trials Could Save Time And Money, Improve Patient Care
5. Moles Among The Older Generation May Be Dangerous
6. Generation Scotland To Examine Relation Between Lifestyle, Genetics and Health
7. Baby Gloom: ‘Baby Gap’ Generation Signals Babies’ Days Ot!
8. Researchers Aim To Develop Next Generation Of Surgical Robots
9. New Generation Teenagers Addiction to Prescription Drugs
10. New Generation - Medicinal Products
11. Take Third Generation Oral Contraceptives Off the Shelves-consumer Group Insists
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/27/2016)... ... 27, 2016 , ... W.S. Badger Co. Inc ., the maker of ... recognized as one of the best small businesses for new dads by Fatherly, the ... small businesses providing progressive benefits to new parents on the organization’s 2016 Best ...
(Date:5/27/2016)... ... May 27, 2016 , ... In response ... many who are unaware of the plight of aphasia. In collaboration with the ... “Stroke Awareness” campaign. , The link between stroke and aphasia is relatively unknown, ...
(Date:5/27/2016)... ... May 27, 2016 , ... With a ... medical and food industries. Aside from its GMP accreditation, Validation Center is also ... successfully certified products, services and staff. , Validation Center is ISO17025 accredited and ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... outcomes, hosted members and suppliers for its inaugural Member Conference at the Paris ... mission of elevating the operational health of America’s healthcare providers. , The conference ...
(Date:5/26/2016)... ... May 26, 2016 , ... Cardiac arrhythmia is ... impact on long-term patient survival, reports a team of UPMC researchers in the ... in the Journal of Thoracic and Cardiovascular Surgery, provide critical information that will ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... New Zealand , May 24, 2016 ... and informatics solutions for the healthcare sector, has been named ... New Zealand Hi-Tech Awards 2016. Dr Bruce ... fantastic acknowledgement for our team.  It,s really good to be ... burden healthcare internationally. Our products are used in 35 countries ...
(Date:5/24/2016)... , May 24, 2016  Joe Marziani has joined VMS BioMarketing as senior ... executive officer, today. In his new role, Marziani will lead the company,s business development ... professionals to improve outcomes. Photo - http://photos.prnewswire.com/prnh/20160523/371089 ... ... ...
(Date:5/24/2016)... 24, 2016 ... , la première endoprothèse à double thérapie ... l,intervention portant sur les membres inférieurs et ... OrbusNeich, entreprise mondiale spécialisée dans la fourniture ... vie, a élargi son portefeuille pour inclure ...
Breaking Medicine Technology: