Navigation Links
Leptin, The Next Generation Antidepressant?

A study conducted by Xin-Yun Lu, PhD and colleagues of the University of Texas Health Science Center found that Leptin when administered to the rat acts as an anti-depressant. Leptin is a hormone mainly given to people involved in weight regulation. //

The research was done on chronic unpredictable stress (CUS) rats. It was found that CUS rats had decreased levels of Leptin than the control rats. Hence this led to the idea that this hormone might play a significant role in assuaging depression symptoms in man. These findings were reported in the online Proceedings of the National Academy of Sciences.

The researchers say that there is very limited source on the data related to assuaging depression in humans using Leptin. For example in two studies it was proved that reduced Leptin plasma levels were seen in depressed patient an increased levels were found in patients undergoing Leptin anti-depressant therapies.

The researchers say that their finding are very useful because currently anti-depressant therapies are not of much use to the people because many of them do not respond to it.

They said that rats are the best animal models and especially CUS rats do not eat sucrose solution, which can be compared to the inability of man to enjoy his life (depression).

CUS rats don’t explore open space and give up easily in case of forced swimming test. It was found that they had lowered Leptin plasma levels and when retrained further for 30 minutes resulted in the further drop of Leptin levels. When these rats are injected with Leptin they have increased appetites for sucrose solution while the normal rats did no do so.

This study analyzed two sets of CUS rats one was administered Leptin (1mg/kg) other set was given Norpramin (desipramine), a medication used as an antidepressant in humans before the forced swimming test. It was found that 15mg/kg of Norpramin was comparable to 1.0 mg/kg of Leptin.

They a lso found that Intrahippocampal infusions of Leptin caused anti-depressant like effect in the forced swimming test. But on the other hand hypothalamus infusion of Leptin had no effect on forced swimming test. Then they came up with the notion that hippocampus is a brain is mediating Leptin's antidepressant-like activity.


'"/>




Related medicine news :

1. Hearing Problems Of Middle Age Are Affecting The Younger Generation
2. Tigecycline – New Generation Tetracycline With Broad Spectrum Antibacterial Activit
3. Newer Generation Sleeping Pills Lack Superior Performance
4. New Generation Clinical Trials Could Save Time And Money, Improve Patient Care
5. Moles Among The Older Generation May Be Dangerous
6. Generation Scotland To Examine Relation Between Lifestyle, Genetics and Health
7. Baby Gloom: ‘Baby Gap’ Generation Signals Babies’ Days Ot!
8. Researchers Aim To Develop Next Generation Of Surgical Robots
9. New Generation Teenagers Addiction to Prescription Drugs
10. New Generation - Medicinal Products
11. Take Third Generation Oral Contraceptives Off the Shelves-consumer Group Insists
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/8/2016)... ... December 08, 2016 , ... Coppin Insurance Agency, an ... families in and around the Cape Coral area, is embarking on a charity drive ... of Southwest Florida. , The Harry Chapin Food Bank of Southwest Florida works to ...
(Date:12/8/2016)... ... December 08, 2016 , ... Bill Mull Agencies, a Wichita-based ... and around central Kansas, is joining the Youth Horizons organization for a charity ... Headquartered in Wichita, Youth Horizons works to empower area children from unstable, troubled, ...
(Date:12/7/2016)... , ... December 07, 2016 , ... ... the passage of the most comprehensive mental health systems reform legislation in more ... of the President, and the commitment of our elected officials to improving mental ...
(Date:12/7/2016)... ... December 07, 2016 , ... Silhouette Instalift is a ... smoothing and tightening the skin of the face to create more youthful features. ... with very little downtime, Silhouette Instalift is a novel, minimally invasive facial procedure ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... S.L. (“Presence”) for a purchase price of approximately $17.4 million (net of ... annual revenue is approximately $13.2 million. Headquartered in Barcelona, Spain, Presence is ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... , Dec. 8, 2016 Dignitana, a world ... partnership with Boa® Technology, creator of the award-winning, patented ... for use with the DigniCap® scalp cooling system. DigniCap® ... in December 2015, and is the first medical scalp ... DigniCap® scalp cooling system features a patented tight-fitting silicone ...
(Date:12/8/2016)... , December 8, 2016 ... Excipients Market by Product (Actual Sugars, Sugar Alcohols, ... & Diluent, Tonicity Agents), Formulation (Oral, Topical, Parenteral) ... the market has witnessed healthy growth during the ... a CAGR of 4.3% between 2016 and 2021 ...
(Date:12/8/2016)... 2016  Hanson Research, an innovative leader in ... diffusion testing instruments for the pharmaceutical industry, announced ... Inc. ("Teledyne"). The move is designed to deepen ... instruments, as well as expand resources for further ... and services. Logo - http://photos.prnewswire.com/prnh/20161208/446988LOGO ...
Breaking Medicine Technology: