Navigation Links
Leptin, The Next Generation Antidepressant?

A study conducted by Xin-Yun Lu, PhD and colleagues of the University of Texas Health Science Center found that Leptin when administered to the rat acts as an anti-depressant. Leptin is a hormone mainly given to people involved in weight regulation. //

The research was done on chronic unpredictable stress (CUS) rats. It was found that CUS rats had decreased levels of Leptin than the control rats. Hence this led to the idea that this hormone might play a significant role in assuaging depression symptoms in man. These findings were reported in the online Proceedings of the National Academy of Sciences.

The researchers say that there is very limited source on the data related to assuaging depression in humans using Leptin. For example in two studies it was proved that reduced Leptin plasma levels were seen in depressed patient an increased levels were found in patients undergoing Leptin anti-depressant therapies.

The researchers say that their finding are very useful because currently anti-depressant therapies are not of much use to the people because many of them do not respond to it.

They said that rats are the best animal models and especially CUS rats do not eat sucrose solution, which can be compared to the inability of man to enjoy his life (depression).

CUS rats don’t explore open space and give up easily in case of forced swimming test. It was found that they had lowered Leptin plasma levels and when retrained further for 30 minutes resulted in the further drop of Leptin levels. When these rats are injected with Leptin they have increased appetites for sucrose solution while the normal rats did no do so.

This study analyzed two sets of CUS rats one was administered Leptin (1mg/kg) other set was given Norpramin (desipramine), a medication used as an antidepressant in humans before the forced swimming test. It was found that 15mg/kg of Norpramin was comparable to 1.0 mg/kg of Leptin.

They a lso found that Intrahippocampal infusions of Leptin caused anti-depressant like effect in the forced swimming test. But on the other hand hypothalamus infusion of Leptin had no effect on forced swimming test. Then they came up with the notion that hippocampus is a brain is mediating Leptin's antidepressant-like activity.


'"/>




Related medicine news :

1. Hearing Problems Of Middle Age Are Affecting The Younger Generation
2. Tigecycline – New Generation Tetracycline With Broad Spectrum Antibacterial Activit
3. Newer Generation Sleeping Pills Lack Superior Performance
4. New Generation Clinical Trials Could Save Time And Money, Improve Patient Care
5. Moles Among The Older Generation May Be Dangerous
6. Generation Scotland To Examine Relation Between Lifestyle, Genetics and Health
7. Baby Gloom: ‘Baby Gap’ Generation Signals Babies’ Days Ot!
8. Researchers Aim To Develop Next Generation Of Surgical Robots
9. New Generation Teenagers Addiction to Prescription Drugs
10. New Generation - Medicinal Products
11. Take Third Generation Oral Contraceptives Off the Shelves-consumer Group Insists
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... ... June 27, 2016 , ... TherapySites, ... today its affiliation with Tennessee Counseling Association. This new relationship allows ... the Tennessee Counseling Association, adding exclusive benefits and promotional offers. , "TCA is ...
(Date:6/26/2016)... N.J. (PRWEB) , ... June 27, 2016 , ... Quality ... sources, yet in many ways they remain in the eye of the beholder, according ... (EBO), a publication of The American Journal of Managed Care. For the full issue, ...
(Date:6/26/2016)... ... 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping to ... app. The fitness app plans to fix the two major problems leading the fitness industry ... fits all type program , They don’t eliminate all the reasons people quit ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library ... City Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ... for fumigation is not a common occurrence, but a necessary one in the event that ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson ... Recently, he has implemented orthobiologic procedures as a method for treating his patients. ... the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... LAS VEGAS , June 26, 2016 ... movement to value-based care operating models within the health ... that enable greater financial efficiency , Deloitte offers ... address the key business issues impacting efficient cost optimization: ... alignment , These services facilitate better outcomes and ...
(Date:6/24/2016)... 24, 2016   Bay Area Lyme Foundation ... Dean Center for Tick Borne Illness , Harvard ... MIT Hacking Medicine, University of California, Berkeley, and ... the five finalists of Lyme Innovation , ... than 100 scientists, clinicians, researchers, entrepreneurs, and investors ...
(Date:6/24/2016)... -- Dehaier Medical Systems Ltd. (NASDAQ: DHRM ... sells medical devices and wearable sleep respiratory products in ... agreement with Hongyuan Supply Chain Management Co., Ltd. (hereinafter ... 2016, to develop Dehaier,s new Internet medical technology business. ... leverage Hongyuan Supply Chain,s sales platform to reach Dehaier,s ...
Breaking Medicine Technology: