Navigation Links
Learning process to be regulated by altering brain protein

Identification of a new biochemical switch that affects how neurons fire in a part of the brain associated with learning could pave way for better understanding of schizophrenia and Alzheimer's disease. //

A protein named “ Reelin”, an important component of the nervous system has been the focus of the research. During development, reelin sends cues to migrating neurons, telling them where they're supposed to go. In adult mice, reelin has recently been implicated in the formation of memories. Reduced production of the protein has been associated with schizophrenia in humans. Emphasis has been laid on a specific area of the brain called the hippocampus, which is important for learning. The interaction of reelin and two other molecules, Apoer2 and the NMDA receptor has also been studied. In the nervous system, the NMDA receptor is embedded in the gaps between nerve cells - where it is involved in receiving signals from other nerve cells. Apoer2 is another receptor, which is associated with the NMDA receptor. When reelin encounters the cell, it attaches to Apoer2, which then boosts the activity of the NMDA receptor by promoting a chemical modification of the part of the NMDA receptor inside the cell. The result of this modification is that signals being received by the nerve cell are amplified - and better reception means better learning. This transition in the primary function of Apoer2, from guiding neurons in the embryonic brain to regulating synaptic signaling, occurs around the time of birth. A small string of amino acids gets added near one end of Apoer2 and is essential for this new function. This longer form of Apoer2 is necessary for reelin to act upon the NMDA receptor. When reelin binds to the longer Apoer2, the NMDA receptor alters its structure and actions, resulting in the strengthening of the signals the nerve cells receive. In addition to reelin, Apoer2 binds to a protein called ApoE. One form of this molecule, called ApoE4, has been shown to substantially increase the risk of Alzheimer's disease in older people. Understanding how ApoE4 functions in the brain and interacts with ApoE receptors, such as Apoer2, is critical for gaining further insight into the mysterious mechanisms that causes neurodegenerative disease.
'"/>




Related medicine news :

1. Habit Memory May Enhance Learning In People
2. Learning Just How Different We Are
3. Better Research Rats To Help In Learning About Hypertension
4. Math Learning Disorder Higher in Boys
5. Math Learning Disorder Higher In Boys
6. Boys Suffer More Mathematics Learning Disorder Than Girls
7. Learning About Healthy Diet Choices Begins At Schools
8. Task Learning Made Simple By Taking Short Breaks
9. Novel Treatment to Cure People with Learning Disabilities
10. Learning the Value of Prevention and Treatment in Oral Clefting
11. Study Shows Tomosyn Plays an Important Role in Learning and Memory
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... “The Journey: ... faced every danger possible to save lost souls in the Philippines. “The Journey: From ... Carole is a dedicated teacher of the Bible. She has taught all ages and ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... advisory services for healthcare compliance program management, will showcase a range of technology ... Association for Assisted Living (NCAL) Convention and Expo to be held October 14–18, ...
(Date:10/12/2017)... LA (PRWEB) , ... October 12, 2017 , ... Planet ... in the U.S., announced today its plans to open a flagship location in Covington, ... occupy the former Rooms To Go store next to Office Depot in the Holiday ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one ... an innovative new design of the shoulder pad. The shoulder pad provides optimal ... controlling your pain while using cold therapy. By utilizing ice and water that is ...
(Date:10/12/2017)... ... 12, 2017 , ... Asante, a nationally recognized health system ... their existing home health joint venture through an agreement, effective October 1, 2017, ... venture home health company with Asante, delivering clinically integrated care, for the past ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... 2017  As the latest Obamacare repeal effort moves ... (R-LA) and Lindsey Graham (R-SC) medical ... device industry is in an odd place.  The industry ... excise tax on medical device sales passed along with ... patients, increased visits and hospital customers with the funding ...
(Date:9/19/2017)... , Sept. 19, 2017   ZirMed Inc ., a ... today announced that it has been ranked #1 by its ... Book™ Rankings 2017 User Survey. ZirMed was recognized as ... large hospitals and medical centers over 200 beds and holds ... healthcare technology user survey history. ...
(Date:9/13/2017)... Sept. 13, 2017   OrthoAtlanta has been named ... Football Host Committee (AFHC) for the 2018 College Football Playoff ... 2018, at Mercedes-Benz Stadium in Atlanta, Georgia ... AFHC "I,m In" campaign, participating in many activities leading up ... ...
Breaking Medicine Technology: