Navigation Links
Learning process to be regulated by altering brain protein

Identification of a new biochemical switch that affects how neurons fire in a part of the brain associated with learning could pave way for better understanding of schizophrenia and Alzheimer's disease. //

A protein named “ Reelin”, an important component of the nervous system has been the focus of the research. During development, reelin sends cues to migrating neurons, telling them where they're supposed to go. In adult mice, reelin has recently been implicated in the formation of memories. Reduced production of the protein has been associated with schizophrenia in humans. Emphasis has been laid on a specific area of the brain called the hippocampus, which is important for learning. The interaction of reelin and two other molecules, Apoer2 and the NMDA receptor has also been studied. In the nervous system, the NMDA receptor is embedded in the gaps between nerve cells - where it is involved in receiving signals from other nerve cells. Apoer2 is another receptor, which is associated with the NMDA receptor. When reelin encounters the cell, it attaches to Apoer2, which then boosts the activity of the NMDA receptor by promoting a chemical modification of the part of the NMDA receptor inside the cell. The result of this modification is that signals being received by the nerve cell are amplified - and better reception means better learning. This transition in the primary function of Apoer2, from guiding neurons in the embryonic brain to regulating synaptic signaling, occurs around the time of birth. A small string of amino acids gets added near one end of Apoer2 and is essential for this new function. This longer form of Apoer2 is necessary for reelin to act upon the NMDA receptor. When reelin binds to the longer Apoer2, the NMDA receptor alters its structure and actions, resulting in the strengthening of the signals the nerve cells receive. In addition to reelin, Apoer2 binds to a protein called ApoE. One form of this molecule, called ApoE4, has been shown to substantially increase the risk of Alzheimer's disease in older people. Understanding how ApoE4 functions in the brain and interacts with ApoE receptors, such as Apoer2, is critical for gaining further insight into the mysterious mechanisms that causes neurodegenerative disease.
'"/>




Related medicine news :

1. Habit Memory May Enhance Learning In People
2. Learning Just How Different We Are
3. Better Research Rats To Help In Learning About Hypertension
4. Math Learning Disorder Higher in Boys
5. Math Learning Disorder Higher In Boys
6. Boys Suffer More Mathematics Learning Disorder Than Girls
7. Learning About Healthy Diet Choices Begins At Schools
8. Task Learning Made Simple By Taking Short Breaks
9. Novel Treatment to Cure People with Learning Disabilities
10. Learning the Value of Prevention and Treatment in Oral Clefting
11. Study Shows Tomosyn Plays an Important Role in Learning and Memory
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2017)... , ... March 27, 2017 , ... ... Conventional sodium testing methods are complicated and require expert user knowledge. In a ... analytical method dedicated to the simplified, yet highly accurate, determination of sodium. , ...
(Date:3/27/2017)... ... March 27, 2017 , ... ... 167%,(1) with opioids alone responsible for over 33,000 of the 52,404 drug-related deaths ... Assembly Bill (AB) 1512, which proposes a tax on prescription opioids to fund ...
(Date:3/25/2017)... , ... March 25, 2017 , ... Getting earned media ... public relations partner. , All through the year, Garden Media aims to provide ... working with key influencers and pitching client’s key messages to gain coveted ...
(Date:3/24/2017)... ... 24, 2017 , ... Mediaplanet today announces distribution of its ... obstacles facing infection prevention and offer strategies for the health care community to ... , The print component of “Fighting Infection” is distributed within the Friday, March ...
(Date:3/24/2017)... Dallas, Texas (PRWEB) , ... March 24, 2017 , ... ... Budget Office score is invalid because it does not obey the rules Congress has ... million full-time equivalent jobs, which the GOP reform would restore. Yet, it estimates a ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... , March 24, 2017 ... providing high-quality and cost-effective drug development and ... pharmaceutical and biotechnology industry, announced today the ... ShangPharma will be consolidating the Contract ... (CMO) under Shanghai ChemPartner. These entities include ...
(Date:3/24/2017)... , March 24, 2017 A ReportsnReports.com report ... been growing rapidly as the global sales of Adcetris and Kadcyla ... in the antibody drug conjugates market is driven by large number ... and wider therapeutic window offered by ADCs. ... Browse 3 Tables and 94 Figures, 10 ...
(Date:3/24/2017)... , March 24, 2017  Eli Lilly ... announced plans to invest $850 million in its ... facilities across its U.S. enterprise, including research laboratories, ... investments are being driven by demand for Lilly ... potential medicines in development targeting cancer, pain, diabetes ...
Breaking Medicine Technology: