Navigation Links
Learning process to be regulated by altering brain protein

Identification of a new biochemical switch that affects how neurons fire in a part of the brain associated with learning could pave way for better understanding of schizophrenia and Alzheimer's disease. //

A protein named “ Reelin”, an important component of the nervous system has been the focus of the research. During development, reelin sends cues to migrating neurons, telling them where they're supposed to go. In adult mice, reelin has recently been implicated in the formation of memories. Reduced production of the protein has been associated with schizophrenia in humans. Emphasis has been laid on a specific area of the brain called the hippocampus, which is important for learning. The interaction of reelin and two other molecules, Apoer2 and the NMDA receptor has also been studied. In the nervous system, the NMDA receptor is embedded in the gaps between nerve cells - where it is involved in receiving signals from other nerve cells. Apoer2 is another receptor, which is associated with the NMDA receptor. When reelin encounters the cell, it attaches to Apoer2, which then boosts the activity of the NMDA receptor by promoting a chemical modification of the part of the NMDA receptor inside the cell. The result of this modification is that signals being received by the nerve cell are amplified - and better reception means better learning. This transition in the primary function of Apoer2, from guiding neurons in the embryonic brain to regulating synaptic signaling, occurs around the time of birth. A small string of amino acids gets added near one end of Apoer2 and is essential for this new function. This longer form of Apoer2 is necessary for reelin to act upon the NMDA receptor. When reelin binds to the longer Apoer2, the NMDA receptor alters its structure and actions, resulting in the strengthening of the signals the nerve cells receive. In addition to reelin, Apoer2 binds to a protein called ApoE. One form of this molecule, called ApoE4, has been shown to substantially increase the risk of Alzheimer's disease in older people. Understanding how ApoE4 functions in the brain and interacts with ApoE receptors, such as Apoer2, is critical for gaining further insight into the mysterious mechanisms that causes neurodegenerative disease.
'"/>




Related medicine news :

1. Habit Memory May Enhance Learning In People
2. Learning Just How Different We Are
3. Better Research Rats To Help In Learning About Hypertension
4. Math Learning Disorder Higher in Boys
5. Math Learning Disorder Higher In Boys
6. Boys Suffer More Mathematics Learning Disorder Than Girls
7. Learning About Healthy Diet Choices Begins At Schools
8. Task Learning Made Simple By Taking Short Breaks
9. Novel Treatment to Cure People with Learning Disabilities
10. Learning the Value of Prevention and Treatment in Oral Clefting
11. Study Shows Tomosyn Plays an Important Role in Learning and Memory
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/25/2016)... Pines, FL (PRWEB) , ... ... ... West has received the American Heart Association/American Stroke Association's Get With The ... designation. , This achievement, a second for Memorial Healthcare System, recognizes ...
(Date:5/25/2016)... ... ... The Georgia State University College of Law new building at 85 Park Place ... annual award recognizes projects, programs, individuals and organizations that have significantly contributed toward the ... and the balance between the old and the new. , “Winning a 2016 Award ...
(Date:5/25/2016)... Netherlands (PRWEB) , ... May 25, 2016 , ... A ... freedom of movement to motion capture, all by utilizing a common Wi-Fi network and ... users to transmit data from any location with Wi-Fi, and use a mobile device ...
(Date:5/25/2016)... ... ... One Florida-based plastic surgeon’s enthusiasm is proving to be contagious among a ... 13th on Vanity Fair. In fact, as the article explains, more than a few ... than 800,000 Snapchat fans. Commenting on this trend, Dr. Michael Salzhauer, also known as ...
(Date:5/25/2016)... , ... May 25, 2016 , ... The Bank of ... Biomedical Technology Program to help provide veterans a pathway to employment and successful careers ... a $20,000 check to Nick Hallack, President and CEO of Medisend, parent organization and ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... AMSTERDAM , May 24, 2016 ... auf den Markt gebracht, die es Ärzten erlaubt, ... überall zu behandeln: MDLinking kombiniert Live Streaming mit ... sicheren Umfeld zu kommunizieren. Mediziner in Europa, Afrika, ... haben sich bereits für die Plattform registriert. ...
(Date:5/24/2016)... , May 24, 2016 ARANZ ... for the healthcare sector, has been named the Coretex Hi-Tech ... Awards 2016. Dr Bruce Davey , CEO ... our team.  It,s really good to be recognised for the ... Our products are used in 35 countries around the world ...
(Date:5/24/2016)... 2016 Los innovadores de ... mundo, introduce catéteres para la intervención de extremidades ... compañía global especializada en el suministro de soluciones ... cartera incluyendo productos para tratar la enfermedad arterial ... son los dispositivos de primera entrada de la ...
Breaking Medicine Technology: