Navigation Links
Learning process to be regulated by altering brain protein

Identification of a new biochemical switch that affects how neurons fire in a part of the brain associated with learning could pave way for better understanding of schizophrenia and Alzheimer's disease. //

A protein named “ Reelin”, an important component of the nervous system has been the focus of the research. During development, reelin sends cues to migrating neurons, telling them where they're supposed to go. In adult mice, reelin has recently been implicated in the formation of memories. Reduced production of the protein has been associated with schizophrenia in humans. Emphasis has been laid on a specific area of the brain called the hippocampus, which is important for learning. The interaction of reelin and two other molecules, Apoer2 and the NMDA receptor has also been studied. In the nervous system, the NMDA receptor is embedded in the gaps between nerve cells - where it is involved in receiving signals from other nerve cells. Apoer2 is another receptor, which is associated with the NMDA receptor. When reelin encounters the cell, it attaches to Apoer2, which then boosts the activity of the NMDA receptor by promoting a chemical modification of the part of the NMDA receptor inside the cell. The result of this modification is that signals being received by the nerve cell are amplified - and better reception means better learning. This transition in the primary function of Apoer2, from guiding neurons in the embryonic brain to regulating synaptic signaling, occurs around the time of birth. A small string of amino acids gets added near one end of Apoer2 and is essential for this new function. This longer form of Apoer2 is necessary for reelin to act upon the NMDA receptor. When reelin binds to the longer Apoer2, the NMDA receptor alters its structure and actions, resulting in the strengthening of the signals the nerve cells receive. In addition to reelin, Apoer2 binds to a protein called ApoE. One form of this molecule, called ApoE4, has been shown to substantially increase the risk of Alzheimer's disease in older people. Understanding how ApoE4 functions in the brain and interacts with ApoE receptors, such as Apoer2, is critical for gaining further insight into the mysterious mechanisms that causes neurodegenerative disease.
'"/>




Related medicine news :

1. Habit Memory May Enhance Learning In People
2. Learning Just How Different We Are
3. Better Research Rats To Help In Learning About Hypertension
4. Math Learning Disorder Higher in Boys
5. Math Learning Disorder Higher In Boys
6. Boys Suffer More Mathematics Learning Disorder Than Girls
7. Learning About Healthy Diet Choices Begins At Schools
8. Task Learning Made Simple By Taking Short Breaks
9. Novel Treatment to Cure People with Learning Disabilities
10. Learning the Value of Prevention and Treatment in Oral Clefting
11. Study Shows Tomosyn Plays an Important Role in Learning and Memory
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2017)... CA (PRWEB) , ... June 25, 2017 , ... FCPX ... media into an old-fashioned vintage look. FCPX LUT Vintage Volume 2 contains 60 different ... film grain for distorted looks, vignettes and blurs to single out subjects, plus much ...
(Date:6/25/2017)... ... ... Republicans in the United States Senate on Thursday released their version of bill ... significantly from the American Health Care Act, which the House passed in May, so ... have to take up the Senate version as-is, if it passes. , The following ...
(Date:6/25/2017)... ... June 25, 2017 , ... CareSet Labs released the Root NPI Graph today ... a new, greatly improved version of the Doctor Referral teaming dataset commonly available from ... and subsequently called the the “Doctor Referral Dataset” as released by Medicare and “DocGraph” ...
(Date:6/25/2017)... ... ... Men’s Health Month and the focus is on prostate cancer. Second only to skin ... third most common cause of cancer related death today; lung cancer remains in the number ... prostate cancer during his lifetime. Those at highest risk are men who have ...
(Date:6/24/2017)... ... June 24, 2017 , ... ... at the Sheraton Erie Bayfront and Erie Convention Center on June 8-10. ... exhibits, a student quiz bowl, award and scholarship presentations, and professional networking. ...
Breaking Medicine News(10 mins):
(Date:5/26/2017)... 25, 2017  In response to the opioid epidemic ... Relief is working with Pfizer to make up to ... cost to community health centers, free and charitable clinics, ... "Pfizer has a long-standing commitment to improving ... patient safety through educational activities," said Caroline Roan ...
(Date:5/22/2017)... , May 22, 2017  Lilac Corp, ... Gene-Eden-VIR/Novirin, announces the launch of a new ... the results of a clinical study that showed ... treatment with Gene-Eden-VIR/Novirin in individuals suffering from HPV ... note that there are no other treatments that ...
(Date:5/18/2017)... 2017  Bayer announced today that the latest research ... at the 53 rd Annual Meeting of the ... 2-6 in Chicago . ... colorectal, liver and thyroid cancers, as well as lymphomas, ... CHRONOS-1 trial of copanlisib in patients with relapsed or ...
Breaking Medicine Technology: