Navigation Links
Learning Slows Physical Progression of Alzheimer's Disease: Study

Scientists at UC Irvine have discovered that learning appears to slow the development of two brain lesions that are the hallmarks of Alzheimer's disease.// The finding suggests that the elderly, by keeping their minds active, can help delay the onset of this degenerative disease. The study appears in the Jan. 24 issue of the Journal of Neuroscience.

This study with genetically modified mice is the first to show that short but repeated learning sessions can slow a process known for causing the protein beta amyloid to clump in the brain and form plaques, which disrupt communication between cells and lead to symptoms of Alzheimer's disease.

Learning also was found to slow the buildup of hyperphosphorylated-tau, a protein in the brain that can lead to the development of tangles, the other signature lesion of the disease. Scientists say these findings have large implications for the understanding and treatment of Alzheimer's disease, as it is already known that highly educated individuals are less likely to develop the disease than people with less education.

"This study shows learning can delay the progression of Alzheimer's neuropathology in mice genetically engineered to develop this insidious disorder, and learning also delays the cognitive decline," said Frank LaFerla, professor of neurobiology and behavior and co-author of the study.

"These remarkable findings suggest stimulating the mind with activities such as reading books or completing crossword puzzles may help delay and/or prevent Alzheimer's disease in senior citizens."

LaFerla; James McGaugh, research professor of neurobiology and behavior; and postdoctoral researchers Kim Green and Lauren Billings studied hundreds of mice between two and 18 months of age that were bred to develop the plaques and tangles characteristic of the disease. Mice in one group were allowed to "learn" by swimming in a round tank of water until they found a submerged pla tform on which to stand.

These mice received training four times a day for one week at two, six, nine, 12, 15 and 18 months of age, and were evaluated at each session for learning and memory abilities. Other groups of untrained mice were allowed to swim in the tank for just one session before their learning and memory skills were tested and their brains examined for plaques and tangles.

Mice up to 12 months of age that learned on previous occasions had fewer plaques and tangles in their brains, and they learned and remembered the location of the escape platform much better than mice not previously allowed to learn. At the 12-month point, the mice that had learned developed levels of beta amyloid and hyperphosphorylated-tau that were 60 percent less than the mice that had not learned; but, by 15 months of age, the mice that had learned deteriorated and were identical both physically and cognitively to the mice that had not learned.

"We were surprised this mild learning had such big effects at reducing Alzheimer's disease pathology and cognitive decline, but the effects were not strong enough to overcome later and more severe pathology," Green said. "We are now investigating if more frequent and vigorous learning will have bigger and longer benefits to Alzheimer's disease."

LaFerla and other colleagues developed the transgenic mice used in this study. These mice, bred to develop the brain lesions associated with Alzheimer's, now are used by scientists worldwide to study the disease.

Alzheimer's is a progressive neurodegenerative disorder that affects more than 4.5 million adults in the United States. With an aging population, that number could approach 20 million by 2050. Alzheimer's is the third-leading cause of death, behind cancer and heart disease. Five percent of people older than 65 have Alzheimer's, and up to one-half of people are affected by age 80.



Source-Eurekalert
SRI
'"/>




Related medicine news :

1. Habit Memory May Enhance Learning In People
2. Learning Just How Different We Are
3. Learning process to be regulated by altering brain protein
4. Better Research Rats To Help In Learning About Hypertension
5. Math Learning Disorder Higher in Boys
6. Math Learning Disorder Higher In Boys
7. Boys Suffer More Mathematics Learning Disorder Than Girls
8. Learning About Healthy Diet Choices Begins At Schools
9. Task Learning Made Simple By Taking Short Breaks
10. Novel Treatment to Cure People with Learning Disabilities
11. Learning the Value of Prevention and Treatment in Oral Clefting
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... ... 2016 , ... "FCPX editors can now reveal their media with growing colorful ... Christina Austin - CEO of Pixel Film Studios. , ProSlice Color brings the ... can now reveal the media of their split screens with growing colorful panels. , ...
(Date:6/26/2016)... ... ... Quality metrics are proliferating in cancer care, and are derived from many ... the beholder, according to experts who offered insights and commentary in the current issue ... the full issue, click here . , For the American Society of Clinical ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many women are confused ... endometriosis. These women need a treatment plan to not only alleviate symptoms and ... help for preservation of fertility and ultimately achieving a pregnancy. The specialists at ...
(Date:6/25/2016)... ... 25, 2016 , ... First Choice Emergency Room , the largest network ... the Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased ... location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... A recent ... that most people are unfamiliar with. The article goes on to state that individuals ... also many of these less common operations such as calf and cheek reduction. The ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on ... today announced that patient enrollment in its ongoing ... Duchenne) has exceeded 50% of its 24-patient target. ... in the third quarter of 2016, and to ...
(Date:6/23/2016)... , June 23, 2016 , ... on Thursday, July 7, 2016 , , , , LOCATION: ... , , , , EXPERT PANELISTS:  , , , ... Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and ... The global pharmaceutical industry is witnessing an exceptional era. ...
(Date:6/23/2016)... LONDON , June 23, 2016 ... environments  Oticon , industry leaders in ... the launch of Oticon Opn ™, the world,s ... world of possibilities for IoT devices.      ... Opn, Oticon introduces a number of ,world firsts,: ...
Breaking Medicine Technology: