( Curioni’s team compared its resul...)Latest Weight-Loss Pill Offers Modest Results, Blocks 'Munchies',Health

Curioni’s team compared its results to a previous review of orlistat and silbutramine, the only drugs approved in the United States for long-term obesity treatment:

"The weight loss associated with rimonabant was slightly greater compared to that related to silbutramine use, with more positive impact on cardiometabolic risk. The effects compared with orlistat appear to be greater weight loss and less frequent adverse effects."

No head-to-head comparisons had been done at the time of the review.

The biggest difference may be in how rimonabant works, by blocking the cannabinoid receptors in the brain. Brownell called rimonabant’s ability to suppress munchies "an interesting finding. The issue of food and addiction hasn’t been explored very much; it should be."

The review authors noted that the four reviewed studies were sponsored by Sanofi companies. With the studies all being sponsored by the drug-maker, results "probably represent a best-case scenario," Brownell said.

None of the studies analyzed drug costs. "The fundamental problem is that even if one of these drugs caused significant weight loss, the cost would be so prohibitive that it wouldn’t be worthwhile on a public health basis," Brownell said. "And only a few people would be able to afford them."

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