( y focused solely on people being treate...)Latest Weight-Loss Pill Offers Modest Results, Blocks 'Munchies',Health

y focused solely on people being treated for type 2 diabetes; another comprised people with high cholesterol or high blood pressure — important factors in heart disease risk.

The authors described the weight loss pattern: "After the 36th week, the level of weight loss decreased and the body weight was maintained practically until the end of the studies." One study evaluated data after two years: "Patients who stayed on 20 mg rimonabant seemed to maintain their weight loss, while those who were re-randomized to placebo gained significant weight."

People on the larger dose lost an average 1.5 inches on their waistlines. They also showed a slight dip in blood pressure. The higher drug dose significantly lowered blood lipids (fats) and increased high-density lipoprotein (“good” cholesterol) by 3.5 mg/dl compared to placebo.

But on the flip side, side effects included nausea, dizziness, headache, joint pain and diarrhea. More serious side effects included psychiatric and nervous system disorders.

Obesity drugs, which often come on the market with great fanfare, can end up being withdrawn in a flurry of lawsuits — like Fen/Phen — or simply produce underwhelming results for people expecting a magic bullet.

"Every time a new drug comes along, it gets a lot of attention. The natural course is that people who want it will try it, and people with have some lackluster results," said Kelly Brownell, Ph.D., director of the Rudd Center for Food Policy and Obesity at Yale University.

"Few people lose enough weight to make themselves happy, more lose enough weight to get some medical benefit but overall results for most treatments for obesity are disappointing," Brownell said.

Rimonabant has been billed for several years as a potential panacea for the most troublesome of habits – obesity, smoking and possibly alcohol addiction. Studies on its use in smoking-cessation studies are currently under way.
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