( at 1.21 for exposed subjects but stil...)Laryngeal Cancer Added to Asbestos’ Crime Lis,Health

at 1.21 for exposed subjects, but still significant. The 95% confidence interval ranged from 1.04 to 1.40.

After adjusting for risk factors like tobacco and alcohol use, the relative risk of cancer for an exposed person became 1.18, with a 95% confidence interval from 1.01 to 1.37.

The IOM stated the following biologically plausible reasons for the link between asbestos and laryngeal cancer:

1. The larynx lies anatomically in the direct path of inhaled asbestos fibers.

2. Squamous-cell carcinomas of the lung and larynx are both clinically and histologically similar.

3. Inflammation or damage to the vocal folds could disrupt the smooth flow of inhaled and exhaled air and allow asbestos fibers to build up in the larynx.

4. Cancers of both lung and larynx arise from the respiratory epithelium.

5. Tobacco is the chief risk factor for cancer at both sites.

The report however reports that there was insufficient evidence that asbestos fibers accumulate and persist in the larynx as well as a lack of experimental animal studies to support this

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