Navigation Links
Largest Ever African HIV Vaccine Trial Opens in South Africa

The South African AIDS Vaccine Initiative (SAAVI) and the HIV Vaccine Trials Network (HVTN) this week launched the African arm of a Phase IIb study utilizing// Merck’s adenovirus trivalent (Ad5 gag/pol/nef) vaccine. The investigators hope to enroll 3,000 HIV-negative men and women over a year, and expect the study to last four years.

The first Phase IIb study (HVTN 502) began enrolling in North and South America, the Caribbean and Australia in 2005, and was known as the STEP study. HVTN 502 was designed to study the vaccine, based on clade B HIV, primarily in men who have sex with men, and some women.

The South African arm, HVTN 503 – also called the Phambili (literally, “moving forward”) study – will examine whether the vaccine has the potential to protect against the clade C virus, the subtype prevalent in South Africa. Analysis of a phase I study presented last year at the Vaccines 06 meeting showed that between 30%-70% of participants who produced responses to subtype B also had responses to subtype A and C.

The South African study is also likely to provide data on the vaccine’s effects on heterosexual HIV transmission; more specific information regarding the vaccine’s effects on women; and whether the vaccine works in a population where there is widespread pre-existing immunity to the adenovirus – the viral vector used in the vaccine. Although there are concerns about the effect of natural immunity to adenovirus reducing its effectiveness, Merck are hoping to work around this by utilizing unusual types of the adenovirus in the vaccine.

"This trial will answer several major scientific issues that face all of us in the field of HIV-vaccine development," notes Dr Lawrence Corey, HVTN’s principal investigator.

The trial, which will be conducted in Cape Town, Soweto, Klerksdorp, Medunsa and Durban, has attracted support from Archbishop Desmond Tutu, entertainer, Loyiso Bala, and pop group, Freshlyground, al l of whom issued their own press releases welcoming the study.

According to an NIAID Q&A webpage, the study organizers have consulted extensively with the community. All participants will receive regular risk-reduction counseling; male and female condoms; and treatment for any sexually transmitted infections (STIs) acquired during the study. In addition, access to circumcision will also be provided to male participants who desire it.

Source-Bio-Bio Technolog
PRI
'"/>




Related medicine news :

1. Worlds Largest Cord Blood Bank to be started in India
2. India Has The Oldest And Largest Collection Of Preserved Mosquitoes – Mosquito Museu
3. Heart Related Problems-The Largest Killers In Andhra Pradesh
4. Children’s Center to Lead Largest-Ever Study on Kidney Disease in Childre
5. Scientists Review Loeys-Dietz Syndrome in the Largest Ever Study to date
6. Missed Vaccination Caused Largest Measles Outbreak in U.S in 2005
7. Primary Health Care Parishioners of Second Largest HIV Infected Area in US Fail to Offer HIV Tests
8. Cipla holds talks with mining giant to supply AIDS drugs for South African workers
9. African HIV strains more resistant to anti HIV drugs
10. Hypertension Drug of Choice for African Americans
11. African Conference to Combat AIDS
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. ... The attorneys chosen by their peers for this recognition are considered among the top ... Shareholders received special honors as members of this year’s Legal Elite Hall of Fame: ...
(Date:6/24/2016)... Diego, CA (PRWEB) , ... June 24, 2016 , ... ... with the American Cancer Society and the Road To Recovery® program to drive cancer ... to seniors and other adults to ensure the highest quality of life and ongoing ...
(Date:6/24/2016)... ... 24, 2016 , ... People across the U.S. are sharpening their pencils and ... essay contest in which patients and their families pay tribute to a genetic counselor ... National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... is proud to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon ... beautiful women in the world, and the most handsome men, look naturally attractive. ...
(Date:6/24/2016)... Maryland (PRWEB) , ... June 24, 2016 , ... ... Angels is actively feeding the Frederick area economy by obtaining investment capital for ... over the past 2½ years that have already resulted in more than a ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...   Pulmatrix, Inc ., (NASDAQ: PULM ... announced today that it was added to the Russell ... comprehensive set of U.S. and global equity indexes on ... milestone for Pulmatrix," said Chief Executive Officer Robert ... progress in developing drugs for crucial unmet medical needs, ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... report to their offering. ... kidney failure, it replaces the function of kidneys by removing ... thus the treatment helps to keep the patient body,s electrolytes ... Increasing number of ESRD patients & substantial healthcare expenditure ...
(Date:6/23/2016)... , June 23, 2016 Roche (SIX: ... 510(k) clearance for its Elecsys BRAHMS PCT (procalcitonin) assay ... sepsis or septic shock. With this clearance, Roche is ... a fully integrated solution for sepsis risk assessment and ... with bacterial infection and PCT levels in blood can ...
Breaking Medicine Technology: