Navigation Links
Largest Ever African HIV Vaccine Trial Opens in South Africa

The South African AIDS Vaccine Initiative (SAAVI) and the HIV Vaccine Trials Network (HVTN) this week launched the African arm of a Phase IIb study utilizing// Merck’s adenovirus trivalent (Ad5 gag/pol/nef) vaccine. The investigators hope to enroll 3,000 HIV-negative men and women over a year, and expect the study to last four years.

The first Phase IIb study (HVTN 502) began enrolling in North and South America, the Caribbean and Australia in 2005, and was known as the STEP study. HVTN 502 was designed to study the vaccine, based on clade B HIV, primarily in men who have sex with men, and some women.

The South African arm, HVTN 503 – also called the Phambili (literally, “moving forward”) study – will examine whether the vaccine has the potential to protect against the clade C virus, the subtype prevalent in South Africa. Analysis of a phase I study presented last year at the Vaccines 06 meeting showed that between 30%-70% of participants who produced responses to subtype B also had responses to subtype A and C.

The South African study is also likely to provide data on the vaccine’s effects on heterosexual HIV transmission; more specific information regarding the vaccine’s effects on women; and whether the vaccine works in a population where there is widespread pre-existing immunity to the adenovirus – the viral vector used in the vaccine. Although there are concerns about the effect of natural immunity to adenovirus reducing its effectiveness, Merck are hoping to work around this by utilizing unusual types of the adenovirus in the vaccine.

"This trial will answer several major scientific issues that face all of us in the field of HIV-vaccine development," notes Dr Lawrence Corey, HVTN’s principal investigator.

The trial, which will be conducted in Cape Town, Soweto, Klerksdorp, Medunsa and Durban, has attracted support from Archbishop Desmond Tutu, entertainer, Loyiso Bala, and pop group, Freshlyground, al l of whom issued their own press releases welcoming the study.

According to an NIAID Q&A webpage, the study organizers have consulted extensively with the community. All participants will receive regular risk-reduction counseling; male and female condoms; and treatment for any sexually transmitted infections (STIs) acquired during the study. In addition, access to circumcision will also be provided to male participants who desire it.

Source-Bio-Bio Technolog
PRI
'"/>




Related medicine news :

1. Worlds Largest Cord Blood Bank to be started in India
2. India Has The Oldest And Largest Collection Of Preserved Mosquitoes – Mosquito Museu
3. Heart Related Problems-The Largest Killers In Andhra Pradesh
4. Children’s Center to Lead Largest-Ever Study on Kidney Disease in Childre
5. Scientists Review Loeys-Dietz Syndrome in the Largest Ever Study to date
6. Missed Vaccination Caused Largest Measles Outbreak in U.S in 2005
7. Primary Health Care Parishioners of Second Largest HIV Infected Area in US Fail to Offer HIV Tests
8. Cipla holds talks with mining giant to supply AIDS drugs for South African workers
9. African HIV strains more resistant to anti HIV drugs
10. Hypertension Drug of Choice for African Americans
11. African Conference to Combat AIDS
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , ... mock evacuation of the facility as part of a disaster drill on October 3rd. ... EMS and Shelton City Emergency Manager, as well as the Connecticut Long Term ...
(Date:10/13/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has released ... understood books in the Holy Scriptures, Revelation. The Book of Revelation paints a picture ... Many have tossed it off as mere rubbish, but Yisrayl Hawkins says that is ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare ... program management, will showcase a range of technology and learning solutions at the ... Convention and Expo to be held October 14–18, 2017 at the Mandalay Bay ...
(Date:10/12/2017)... Bethesda, MD (PRWEB) , ... October 12, 2017 , ... ... Award of Excellence to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s ... 4 – 8. , In honor of Morris F. Collen, a pioneer in the ...
(Date:10/12/2017)... Washington, D.C. (PRWEB) , ... October 12, 2017 , ... ... of their peers in Washington, D.C., for the 49th Congress of the International ... Ph.D ., Vice President of the Center for Cancer and Blood Disorders ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... Md. , Sept. 22, 2017  As the ... Republican Senators Bill Cassidy (R-LA) and ... Information notes that the medical device industry is in ... medical device tax, the 2.3% excise tax on medical ... But they also want covered patients, increased visits and ...
(Date:9/19/2017)... 2017   ZirMed Inc ., a recognized leader in ... it has been ranked #1 by its users for the ... 2017 User Survey. ZirMed was recognized as the top-ranked end-to-end ... medical centers over 200 beds and holds one of the ... survey history. ...
(Date:9/13/2017)... Sept. 13, 2017   OrthoAtlanta has been named ... Football Host Committee (AFHC) for the 2018 College Football Playoff ... 2018, at Mercedes-Benz Stadium in Atlanta, Georgia ... AFHC "I,m In" campaign, participating in many activities leading up ... ...
Breaking Medicine Technology: