Navigation Links
Lactococcus Strain may Offer End to Food Allergies

Non-pathogenic gut bacteria, bioengineered to produce a compound that regulates immune response in the gut, may offer significant potential// for beating food allergies, if results from an animal study can be translated to humans.

Authors Christophe Frossard and Philippe Eigenmann from the University Hospital of Geneva in collaboration with Lothar Steidler from University College Cork bioengineered a strain of Lactococcus lactis to produce anti-inflammatory interleukin-10 (IL-10), a potential regulator for food tolerance.

Writing in the Journal of Allergy and Clinical Immunology, Frossard reports that oral administration of this non-pathogenic strain effectively reduced food-induced anaphylaxis (severe allergic response) in mice and suppressed the production of an antibody capable of initiating the most powerful immune reactions.

"These findings open interesting potential options in human beings for the prevention of allergies elicited through sensitization in the gut," wrote the authors in the Journal of Allergy and Clinical Immunology.

Indeed, corresponding author, Dr. Philippe Eigenmann told FoodNavigator.com: "The potential for the industry is to use in "health" foods probiotics that are engineered to be better tolerance inductor. The big question is how will be accepted by the consumer."

An estimated four per cent of adults and eight per cent of children in the 380m EU population suffer from food allergies, according to the European Federation of Allergy and Airways Diseases Patients' Associations.

The researchers used a mouse model of food allergy to test their hypothesis that oral administration of Lactococcus lactis bioengineered to secrete murine IL-10 could inhibit and/or stop sensitisation.

The mice were sensitised to beta-lactoglobulin in the presence of cholera toxin and then given the L. lactis IL-10-secreting strain. The researchers report that anaphylaxis was reduced signif icantly, while blood levels of antigen-specific immunoglobulin E (IgE) - an antibody subclass capable of initiating the most powerful immune reactions- were also significantly reduced.

Moreover, production of antigen-specific immunoglobulin A (IgA) in the gut

"These results suggest that a microorganism bioengineered to deliver IL-10 in the gut can decrease food-induced anaphylaxis and provide an option to prevent IgE-type sensitization to common food allergens," state the researchers.

Further research is ongoing and Dr. Eigenmann told this website: "The research has been extended to patients with inflammatory colitis in whom the microorganism is well tolerated (phase I trial), and there is some indication that it is also effective for treatment.

"The challenge is going to phase two human trials for prevention, but also for treatment of food allergy," he said.

Allergen labelling regulations that came into force on 25 November require companies to label all pre-packed foods if they contain any of the 12 listed allergenic foods as an ingredient.

The mandatory inclusion on food labels of the most common food allergen ingredients and their derivatives covers cereals containing gluten, fish, crustaceans, egg, peanut, soybeans, milk and dairy products including lactose, nuts, celery, mustard, sesame seed, and sulphites.

Source-Bio-Bio Technology
'"/>




Related medicine news :

1. Strain in marriage may increase chance of heart disease for women
2. New Tools To Identify Flu Strains
3. Bird Flu Strains Detected In Wild Birds Of Mongolia
4. Novel Strain Detected In The Recent Outbreak Of Bird Flu At Ukraine
5. Cyprus Reports H5N1 Strain In Birds
6. Holy Cow! Rare “Mad Sheep” Strain Suspected in Frane
7. Whirlpool Bath Tubs Contain Potentially Lethal Bacterial Strains
8. Strained Economic Agreement Between Singapore And India
9. New Strain Of E Coli Responsible For Outbreak
10. Excessive Text Messaging Causes Repetitive Strain Injury In A Eight Year Old Girl
11. Bird Flu in Thailand Suspected to be H5N1 Strain
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/24/2016)... Loma Linda, CA (PRWEB) , ... May 24, 2016 , ... ... that will house the new adult hospital and expanded Children’s Hospital. Over 3,000 people ... May 22. , Check out the event photo slidehsow. , During the ...
(Date:5/24/2016)... Angeles, CA (PRWEB) , ... May 24, 2016 ... ... to everything egg freezing, today announced the official relaunch of its community and ... use their frozen eggs. Eggsurance's mission is to create a safe and welcoming ...
(Date:5/24/2016)... ... ... Tuesday, May 24, Women's Excellence in Wellness, powered by Movestrong will be ... taught by Patti Dolan, RYT, a Young Living Gold Member. The class is ... 7:15pm followed by a small intro to the Oils that can benefit the student's ...
(Date:5/24/2016)... ... ... In light of recent heavy flooding in Houston, Texas, Pelican Water Systems is ... Houston area. , Heavy floodwaters have led to destroyed waterways and flooded reservoirs. The ... even be aware of the contamination of their water supply and thus, may be ...
(Date:5/24/2016)... ... May 24, 2016 , ... "ProText Layouts Vol. 3 ... Austin - CEO of Pixel Film Studios. , ProText Layouts Vol. 3 is a ... Cut Pro X . With ProText Layouts, video editors can create an lively typography ...
Breaking Medicine News(10 mins):
(Date:5/20/2016)... May 20, 2016 The Biotech ... believe that the industry is not far from recovering. ... ActiveWallSt.com featured the following four equities: Anacor Pharmaceuticals Inc. ... ATHX ), Aralez Pharmaceuticals Inc. (NASDAQ: ... INFI ). Sign up for your free trading alerts ...
(Date:5/20/2016)... According to the 2016 home healthcare market report, ... healthcare solutions as since the early 2000s, the cost of ... the US, the healthcare cost rose faster than inflation during ... inflation rate stood at an average of 2.04% during 2005-2015, ... the same time period. This can be attributed to the ...
(Date:5/19/2016)... May 19, 2016  According to the World ... world lacks basic diagnostic imaging. Whereas mammography or ... the United States , many places around ... In fact, the WHO reports that those approximately ... or treatable death, simply due to the unavailability ...
Breaking Medicine Technology: