Navigation Links
Lactococcus Strain may Offer End to Food Allergies

Non-pathogenic gut bacteria, bioengineered to produce a compound that regulates immune response in the gut, may offer significant potential// for beating food allergies, if results from an animal study can be translated to humans.

Authors Christophe Frossard and Philippe Eigenmann from the University Hospital of Geneva in collaboration with Lothar Steidler from University College Cork bioengineered a strain of Lactococcus lactis to produce anti-inflammatory interleukin-10 (IL-10), a potential regulator for food tolerance.

Writing in the Journal of Allergy and Clinical Immunology, Frossard reports that oral administration of this non-pathogenic strain effectively reduced food-induced anaphylaxis (severe allergic response) in mice and suppressed the production of an antibody capable of initiating the most powerful immune reactions.

"These findings open interesting potential options in human beings for the prevention of allergies elicited through sensitization in the gut," wrote the authors in the Journal of Allergy and Clinical Immunology.

Indeed, corresponding author, Dr. Philippe Eigenmann told FoodNavigator.com: "The potential for the industry is to use in "health" foods probiotics that are engineered to be better tolerance inductor. The big question is how will be accepted by the consumer."

An estimated four per cent of adults and eight per cent of children in the 380m EU population suffer from food allergies, according to the European Federation of Allergy and Airways Diseases Patients' Associations.

The researchers used a mouse model of food allergy to test their hypothesis that oral administration of Lactococcus lactis bioengineered to secrete murine IL-10 could inhibit and/or stop sensitisation.

The mice were sensitised to beta-lactoglobulin in the presence of cholera toxin and then given the L. lactis IL-10-secreting strain. The researchers report that anaphylaxis was reduced signif icantly, while blood levels of antigen-specific immunoglobulin E (IgE) - an antibody subclass capable of initiating the most powerful immune reactions- were also significantly reduced.

Moreover, production of antigen-specific immunoglobulin A (IgA) in the gut

"These results suggest that a microorganism bioengineered to deliver IL-10 in the gut can decrease food-induced anaphylaxis and provide an option to prevent IgE-type sensitization to common food allergens," state the researchers.

Further research is ongoing and Dr. Eigenmann told this website: "The research has been extended to patients with inflammatory colitis in whom the microorganism is well tolerated (phase I trial), and there is some indication that it is also effective for treatment.

"The challenge is going to phase two human trials for prevention, but also for treatment of food allergy," he said.

Allergen labelling regulations that came into force on 25 November require companies to label all pre-packed foods if they contain any of the 12 listed allergenic foods as an ingredient.

The mandatory inclusion on food labels of the most common food allergen ingredients and their derivatives covers cereals containing gluten, fish, crustaceans, egg, peanut, soybeans, milk and dairy products including lactose, nuts, celery, mustard, sesame seed, and sulphites.

Source-Bio-Bio Technology
'"/>




Related medicine news :

1. Strain in marriage may increase chance of heart disease for women
2. New Tools To Identify Flu Strains
3. Bird Flu Strains Detected In Wild Birds Of Mongolia
4. Novel Strain Detected In The Recent Outbreak Of Bird Flu At Ukraine
5. Cyprus Reports H5N1 Strain In Birds
6. Holy Cow! Rare “Mad Sheep” Strain Suspected in Frane
7. Whirlpool Bath Tubs Contain Potentially Lethal Bacterial Strains
8. Strained Economic Agreement Between Singapore And India
9. New Strain Of E Coli Responsible For Outbreak
10. Excessive Text Messaging Causes Repetitive Strain Injury In A Eight Year Old Girl
11. Bird Flu in Thailand Suspected to be H5N1 Strain
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids ... sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited ... all ages; it is a non-competitive, non-timed event, which is all about having fun ...
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of ... Philippines. “The Journey: From the Mountains to the Mission Field” is the creation of ... taught all ages and currently teaches a class of ladies at her church, which ...
(Date:10/12/2017)... ... ... Planet Fitness, one of the largest and fastest growing franchisors and operators ... location in Covington, LA at 401 N. U.S. Highway 190, in January of 2018. ... in the Holiday Square shopping center. Its location allows it to serve both Covington ...
(Date:10/12/2017)... ... ... Asante, a nationally recognized health system in southern Oregon, ... health joint venture through an agreement, effective October 1, 2017, to create AccentCare ... company with Asante, delivering clinically integrated care, for the past eight years. This ...
(Date:10/12/2017)... ... 12, 2017 , ... Leading pediatric oncology experts at Children’s National Health ... Congress of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired ... Cancer and Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... and NEW YORK , Sept. 27, 2017  DarioHealth ... and big data solutions, today announced that its MyDario product is expected ... local TV listings for when The Dr. Oz Show airs in your ... The nine-time Emmy ... ...
(Date:9/22/2017)...  As the latest Obamacare repeal effort moves is ... (R-LA) and Lindsey Graham (R-SC) medical device ... industry is in an odd place.  The industry wants ... tax on medical device sales passed along with the ... increased visits and hospital customers with the funding to ...
(Date:9/18/2017)... , Sept. 18, 2017  PMD Healthcare of ... Pharmacy of Kalamazoo, Mich. , have ... service that expedites and streamlines patient and provider access ... 2.0, and wellness management services.  ... used to measure lung function for a variety of ...
Breaking Medicine Technology: