Navigation Links
Lactococcus Strain may Offer End to Food Allergies

Non-pathogenic gut bacteria, bioengineered to produce a compound that regulates immune response in the gut, may offer significant potential// for beating food allergies, if results from an animal study can be translated to humans.

Authors Christophe Frossard and Philippe Eigenmann from the University Hospital of Geneva in collaboration with Lothar Steidler from University College Cork bioengineered a strain of Lactococcus lactis to produce anti-inflammatory interleukin-10 (IL-10), a potential regulator for food tolerance.

Writing in the Journal of Allergy and Clinical Immunology, Frossard reports that oral administration of this non-pathogenic strain effectively reduced food-induced anaphylaxis (severe allergic response) in mice and suppressed the production of an antibody capable of initiating the most powerful immune reactions.

"These findings open interesting potential options in human beings for the prevention of allergies elicited through sensitization in the gut," wrote the authors in the Journal of Allergy and Clinical Immunology.

Indeed, corresponding author, Dr. Philippe Eigenmann told "The potential for the industry is to use in "health" foods probiotics that are engineered to be better tolerance inductor. The big question is how will be accepted by the consumer."

An estimated four per cent of adults and eight per cent of children in the 380m EU population suffer from food allergies, according to the European Federation of Allergy and Airways Diseases Patients' Associations.

The researchers used a mouse model of food allergy to test their hypothesis that oral administration of Lactococcus lactis bioengineered to secrete murine IL-10 could inhibit and/or stop sensitisation.

The mice were sensitised to beta-lactoglobulin in the presence of cholera toxin and then given the L. lactis IL-10-secreting strain. The researchers report that anaphylaxis was reduced signif icantly, while blood levels of antigen-specific immunoglobulin E (IgE) - an antibody subclass capable of initiating the most powerful immune reactions- were also significantly reduced.

Moreover, production of antigen-specific immunoglobulin A (IgA) in the gut

"These results suggest that a microorganism bioengineered to deliver IL-10 in the gut can decrease food-induced anaphylaxis and provide an option to prevent IgE-type sensitization to common food allergens," state the researchers.

Further research is ongoing and Dr. Eigenmann told this website: "The research has been extended to patients with inflammatory colitis in whom the microorganism is well tolerated (phase I trial), and there is some indication that it is also effective for treatment.

"The challenge is going to phase two human trials for prevention, but also for treatment of food allergy," he said.

Allergen labelling regulations that came into force on 25 November require companies to label all pre-packed foods if they contain any of the 12 listed allergenic foods as an ingredient.

The mandatory inclusion on food labels of the most common food allergen ingredients and their derivatives covers cereals containing gluten, fish, crustaceans, egg, peanut, soybeans, milk and dairy products including lactose, nuts, celery, mustard, sesame seed, and sulphites.

Source-Bio-Bio Technology

Related medicine news :

1. Strain in marriage may increase chance of heart disease for women
2. New Tools To Identify Flu Strains
3. Bird Flu Strains Detected In Wild Birds Of Mongolia
4. Novel Strain Detected In The Recent Outbreak Of Bird Flu At Ukraine
5. Cyprus Reports H5N1 Strain In Birds
6. Holy Cow! Rare “Mad Sheep” Strain Suspected in Frane
7. Whirlpool Bath Tubs Contain Potentially Lethal Bacterial Strains
8. Strained Economic Agreement Between Singapore And India
9. New Strain Of E Coli Responsible For Outbreak
10. Excessive Text Messaging Causes Repetitive Strain Injury In A Eight Year Old Girl
11. Bird Flu in Thailand Suspected to be H5N1 Strain
Post Your Comments:

(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... ... Silver&Fit® Exercise and Healthy Aging Program have announced their endorsement of ... , “American Specialty Health Fitness is proud to have the MFN as one ...
(Date:11/24/2015)... ... ... Dr. Kevin Day, local family chiropractor in Warsaw , is hosting ... During the Indiana winter months, Vitamin D deficiency can lead to Seasonal Affective ... to help provide the tools needed to combat it this year! , “Stress kills ...
(Date:11/24/2015)... ... November 24, 2015 , ... Robert Yeager CEO of PharmMD, has ... past year there have been multiple breakthroughs and challenges as healthcare reform moves out ... enabled their customers and partners to stay ahead of the curve by breaking down ...
(Date:11/24/2015)... , ... November 24, 2015 , ... ... the Business Action on Health Awards, bestowed annually to the world’s best corporate-supported ... commended companies at Global Health Council’s Landscape Symposium held in Washington D.C and ...
(Date:11/24/2015)... Milford, PA (PRWEB) , ... November 24, 2015 ... ... and manufacturer of safety signs and safety labels , has ... AFIA, the world’s largest organization devoted exclusively to representing the business, legislative and ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... 24, 2015 /PRNewswire/ - ESSA Pharma Inc. ("ESSA" or ... today that the first patient has been enrolled in ... treatment for metastatic castration-resistant prostate cancer ("mCRPC"). ... --> the United States ... 1/2 clinical trial, ESSA intends to demonstrate the safety, ...
(Date:11/24/2015)... -- Sectra (STO: SECT B) announces that ... multi-year agreement to deploy Breast Imaging PACS in ... the Breast Center a future-proof platform capable of expanding with ... announces that Breast Center of Acadiana has entered ... PACS in its two freestanding imaging centers. This investment will ...
(Date:11/24/2015)... , Nov. 24, 2015  Ascendant Solutions, Inc. (Pink ... that its Board of Directors has declared a special 1 ... stock dividend is payable December 14, 2015, to shareholders of ... the form of additional shares of common stock. ... the Board is a strong endorsement of our confidence in ...
Breaking Medicine Technology: