Navigation Links
Lack of STAT1 -an Immune Protein, Pack Liver Infection Cure

proteins are responsible for the production of interferon gamma, an important protein that helps launch a full-blown immune system attack against foreign pathogens.

A group of mice with both STAT1 and T-bet genes intact served as a control.

About two weeks after infection, the researchers began measuring the number of L. donovani parasites in the animals’ livers.

The pathogen went wild in the mice that lacked T-bet – the researchers found thousands upon thousands of the parasites in the livers of these animals.

Yet there were next to no parasites in the mice without STAT1.

‘Two weeks after infection, the mice without STAT1 had 25-fold fewer parasites in their liver tissue than the normal mice, and about 100-fold fewer parasites than the mice without T-bet,’ Satoskar said. ‘Visceral leishmaniasis never developed in the animals without STAT1 – the parasites weren’t able to establish an infection in the animals’ livers and spleens.’

The researchers also measured parasite levels in the livers two months after infection. Again, levels were quite high in the mice without T-bet, while normal mice and mice without STAT1 showed no sign of the disease.

While the normal mice weren’t sick – they showed no physical signs of having leishmaniasis, such as inflammation of the liver and spleen – Satoskar said the parasite was still in their systems.

‘Once infected, the parasite never goes away completely,’ Satoskar said. ‘It’s always hiding somewhere.’

Ironically, L. donovani thrives in the liver and spleen by infecting the very cells that the immune system uses to rid the parasite from the body. These cells are called macrophages – a kind of garbage collector for the immune system, as they clean out everything from red blood cells that have died to infectious pathogens. But enough L. donovani parasites can overtake a macrophage’s ability to clean up.

‘L. donovani infection failed to
'"/>




Page: 1 2 3

Related medicine news :

1. Immune cells halt round in space
2. Immune function could benefit from exercise
3. Reviving the Immune System
4. Wrestling found To Be Good for the Immune System
5. Immune Boost With LHRH To Help Cancer And Transplant Patients
6. Researchers Find Out The Cause Of Immune Attacks Behind Hearing Loss
7. Block Immune System Chemical For Treating Asthma
8. Immune Response Of Human Beings Can Be Re-energized
9. Weizmann Institute of Science says Immune Cells Could Help Maintain Brain Function
10. Antidepressant drugs interacts with Immune cells
11. Specific Immune Mechanism against DNA viruses
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Lack STAT1 Immune Protein Pack Liver Infection Cure

(Date:10/22/2014)... Weight Your Body’s Way , In a world where a ... certainly can be difficult to choose the right weight loss ... doing it the healthy way? Set aside the fads and ... exercise regularly, and choose foods with the most nutritional benefits. ... to exercise more and eat less. Despite the number of ...
(Date:10/22/2014)... PA (PRWEB) October 22, 2014 Richard ... as an industry leader with over 25 years experience. ... team leader in the areas related to EDI, B2B ... Carlson is an Editorial Advisory Board member for Pharmaceutical ... Educator. Blue Fin Group is a management and ...
(Date:10/22/2014)... Maureen Salamon HealthDay Reporter ... undergoing in vitro fertilization (IVF) are only about half as ... assisted reproduction technique, new research indicates, and the racial disparity ... study, about 31 percent of white patients became pregnant after ... Analyzing more than 4,000 IVF cycles over two years to ...
(Date:10/22/2014)... HealthDay Reporter TUESDAY, Oct. 21, 2014 ... fertilization (IVF) -- the incubation of embryos in a laboratory ... the vagina, new research suggests. Scientists from the United ... might sharply cut costs for pricey IVF procedures among certain ... those who don,t live near big-city assisted reproduction centers, the ...
(Date:10/22/2014)... HealthDay Reporter TUESDAY, Oct. 21, ... Ebola while working for NBC News in Liberia has ... isolation unit at Nebraska Medical Center in Omaha, where he had ... A blood test confirmed by the U.S. Centers for Disease ... to Providence, R.I., NBC News reported Tuesday night. ...
Breaking Medicine News(10 mins):Health News:ReductionGuruMD Presents Ways to Improve Your Weight Loss Results 2Health News:Rich Carlson and Marc Duey to Hold Workshop at CBI’s Specialty Pharmacy and Distribution Networks Conference 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 3Health News:Experimental Infertility Treatment Seems Effective, Cheaper 2Health News:Experimental Infertility Treatment Seems Effective, Cheaper 3Health News:Experimental Infertility Treatment Seems Effective, Cheaper 4Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 3
... leading cause of disability among adults. As the population ages, ... and public health toll of this chronic, crippling joint disease. ... diagnosis, moderate exercise is one of the most effective ways ... of the knee and hip. , ...
... disease is the major cause of mortality in patients ... with Duchenne muscular dystrophy and approximately 70 % of ... two common forms of muscular dystrophy caused by defects ... with dilated cardiomyopathy (DCM), heart failure and premature death. ...
... transient episodes of bilateral muscle weakness with areflexia ... to narcolepsy. Cataplexy is diagnosed based on clinical ... recently but their usefulness has been limited because ... , ,Used effectively even these screening tests ...
... most often begins in infancy. Sleep disturbances in children with ... not only impact the afflicted child but may // also ... conducted with the aim to evaluate sleep disturbance and co ... association between sleep characteristics and features of the disease. , ...
... researchers have known that high density lipoproteins, commonly called ... from certain parasites. // The mechanism however remained unclear ... ,Human HDLs work by serving as a platform ... proteins that combine to create a super-toxic antimicrobial. ,The ...
... exposure to polluted air is associated with a significant increase ... blood clot travels to the brain. ,Researchers examined the ... separate cities, and found that risk of hospitalization for ischemic ... levels of air pollution, compared with low-air pollution days. ...
Cached Medicine News:Health News:Exercise Can Strenghten Knee Cartilage 2Health News:Air pollution found to increase risk of ischemic stroke 2
(Date:10/22/2014)... -- Moms are ready to live the "measured life" ... kids, according to the results of the BabyCenter® U.S. ... for Moms, the latest installment in BabyCenter,s 21 st ... and parenting web and mobile destination worldwide, conducted the ... say they can,t think of a reason not to ...
(Date:10/22/2014)... 22, 2014 AVACEN Medical announced today that ... (k) OTC clearance by the U.S. Food and Drug ... marketed over the Internet for: the temporary relief ... minor strains and sprains . Logo - ... (MSRP $2495) is a sophisticated medical device incorporating over ...
(Date:10/22/2014)... , Oct. 22, 2014  CryoLife, Inc. (NYSE: ... processing company focused on cardiac and vascular surgery, announced ... and Chief Executive Officer, has been elected to the ... Steven G. Anderson , Executive Chairman of ... proven to be an excellent leader who is well ...
Breaking Medicine Technology:BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 2BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 3BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 4AVACEN Medical Announces FDA Clearance of First Medical Device with Internal Game Mode 2Pat Mackin Joins CryoLife Board of Directors 2Pat Mackin Joins CryoLife Board of Directors 3
... A new report criticizes the US Drug Enforcement ... addictive medications without a valid prescription requirement. ... , analyzes the DEA,s implementation of the Ryan Haight Online ... named after an 18-year old who died after purchasing Vicodin ...
... VIEW, Calif., June 8, 2011 Edison Pharmaceuticals, ... Drug Administration has granted orphan drug designation to ... diseases. Today, these mitochondrial diseases affect an estimated ... passed in 1982, provides incentives for companies to ...
Cached Medicine Technology:Report Criticizes DEA for Failing to Address Online Pharmacy Problem 2Edison Pharmaceuticals Announces FDA Grants EPI-743 Orphan Drug Designation 2
... patients with a diseased heart, the only therapy solution ... transplant. However, donor organs are not always readily available. ... are on the waiting list for a donor organ. ... save the life of a patient. On the one ...
The SonoSite MicroMaxx gives you big machine performance in a lightweight package. This laptop-sized, durable unit represents the technology crossover point between hand-carried ultrasound and larger...
... The Nichols Advantage® 25-Hydroxyvitamin D Assay is ... Specialty System. The Nichols Advantage® 25-Hydroxyvitamin D ... of 25-,hydroxyvitamin D (25-OH-D) and other hydroxylated ... plasma to be used as an aid ...
... The CoaguChek Pro is a ... of the coagulation parameters PT, APTT, ... professional use in hospitals and medical ... e.g., in cardiac catheterization laboratories, and ...
Medicine Products: