Navigation Links
Lack of STAT1 -an Immune Protein, Pack Liver Infection Cure

proteins are responsible for the production of interferon gamma, an important protein that helps launch a full-blown immune system attack against foreign pathogens.

A group of mice with both STAT1 and T-bet genes intact served as a control.

About two weeks after infection, the researchers began measuring the number of L. donovani parasites in the animals’ livers.

The pathogen went wild in the mice that lacked T-bet – the researchers found thousands upon thousands of the parasites in the livers of these animals.

Yet there were next to no parasites in the mice without STAT1.

‘Two weeks after infection, the mice without STAT1 had 25-fold fewer parasites in their liver tissue than the normal mice, and about 100-fold fewer parasites than the mice without T-bet,’ Satoskar said. ‘Visceral leishmaniasis never developed in the animals without STAT1 – the parasites weren’t able to establish an infection in the animals’ livers and spleens.’

The researchers also measured parasite levels in the livers two months after infection. Again, levels were quite high in the mice without T-bet, while normal mice and mice without STAT1 showed no sign of the disease.

While the normal mice weren’t sick – they showed no physical signs of having leishmaniasis, such as inflammation of the liver and spleen – Satoskar said the parasite was still in their systems.

‘Once infected, the parasite never goes away completely,’ Satoskar said. ‘It’s always hiding somewhere.’

Ironically, L. donovani thrives in the liver and spleen by infecting the very cells that the immune system uses to rid the parasite from the body. These cells are called macrophages – a kind of garbage collector for the immune system, as they clean out everything from red blood cells that have died to infectious pathogens. But enough L. donovani parasites can overtake a macrophage’s ability to clean up.

‘L. donovani infection failed to
'"/>




Page: 1 2 3

Related medicine news :

1. Immune cells halt round in space
2. Immune function could benefit from exercise
3. Reviving the Immune System
4. Wrestling found To Be Good for the Immune System
5. Immune Boost With LHRH To Help Cancer And Transplant Patients
6. Researchers Find Out The Cause Of Immune Attacks Behind Hearing Loss
7. Block Immune System Chemical For Treating Asthma
8. Immune Response Of Human Beings Can Be Re-energized
9. Weizmann Institute of Science says Immune Cells Could Help Maintain Brain Function
10. Antidepressant drugs interacts with Immune cells
11. Specific Immune Mechanism against DNA viruses
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Lack STAT1 Immune Protein Pack Liver Infection Cure

(Date:5/4/2015)... Glendale, CA (PRWEB) May 04, 2015 ... intensify as baby boomers join the ranks of senior ... unprecedented demand on an already over-burdened healthcare system. Additionally, ... qualified staff to replace them. Per the U.S. Census ... is expected to increase 75% by 2050 while those ...
(Date:5/4/2015)... Angeles, CA (PRWEB) May 04, 2015 ... Sands, is now offering a more comfortable and attractive ... the restoration of choice for those who have lost ... Dentures can feel insecure or slip at the worst ... patient eats or talks. They can also painfully pinch ...
(Date:5/4/2015)... (PRWEB) May 04, 2015 Pricing Healthcare ... to $3,000) of one patient receiving care at St. ... The procedure must be performed by July 15th, 2015, ... pay in full up front and forego the filing of ... more economically burdensome every year, and it devastates more and ...
(Date:5/4/2015)... 04, 2015 Unlike some camps, the Nike Middle ... The goal is to educate first and train second, with ... ensures that the young runners are building the knowledge base needed ... of the topics covered include Effort Based Training, Running Heroes, Running ... to be? This is not a camp where kids come ...
(Date:5/4/2015)... World T.E.A.M. Sports’ best-attended Face ... the last decade arrived in this historic Civil War ... days from the Pentagon in Arlington, Virginia. The annual ... and able-bodied participants work together to successfully complete the ... the commitment and sacrifices by military veterans in their ...
Breaking Medicine News(10 mins):Health News:U.S. Healthcare Worker Shortage Escalating: Sterling Warns Medical Practitioners to Rapidly Reverse Low Employee Retention 2Health News:U.S. Healthcare Worker Shortage Escalating: Sterling Warns Medical Practitioners to Rapidly Reverse Low Employee Retention 3Health News:U.S. Healthcare Worker Shortage Escalating: Sterling Warns Medical Practitioners to Rapidly Reverse Low Employee Retention 4Health News:Los Angeles Dental Implants Doctor, Kevin Sands DDS, Now Offers a More Comfortable and Aesthetically-Pleasing Solution to Denture-Wearers 2Health News:Pricing Healthcare to Pay a Patient's Bill for a Procedure at Utah Facility 2Health News:Pricing Healthcare to Pay a Patient's Bill for a Procedure at Utah Facility 3Health News:US Sports Camps and Select Nike Running Camps Offer Programs for Middle School Runners 2Health News:Gettysburg Welcomes Arriving Face of America Riders with Gala Celebration 2Health News:Gettysburg Welcomes Arriving Face of America Riders with Gala Celebration 3Health News:Gettysburg Welcomes Arriving Face of America Riders with Gala Celebration 4
... , , Gamers Engage Memory, Attention, ... July 16 /PRNewswire-USNewswire/ -- The MS Technology Collaborative ... to exercise their brain power. The Collaborative, an alliance of Bayer ... launch of MyBrainGames, a free suite of online cognitive games for the ...
... , , , ... of the nation,s leading domestic manufacturers of prescription foot and ... the prestigious Employer of the Year award, which is given ... private sector employers that provide outstanding employment opportunities and support ...
... , , , NEW ... Conference and Exposition (ErgoExpo), Caesars Palace, Las Vegas, November ... speakers that have led 99% of attendees to say they,d ... Management, Office Ergonomics, Industrial Ergonomics & Material Handling, Healthcare ...
... bonds, dedicated scientists set their sights on the bone malignancy chordoma ... Alter had blazing headaches that doctors explained away as lazy eye ... until one day he fell three times in one hour. On ... for his mitt and it would fall to the ground, 10 ...
... , , , ... excited to announce its travel pack product VaNu 2Go+. VaNu 2Go+ combines organic ... in FoL,s flagship product, VaNu. , , VaNu ... The addition of Maca has many reported benefits: increased energy, stamina, and hormone ...
... , Public Comment Period Open for New Standards Aligned ... WASHINGTON, July 16 URAC , a leading health care ... set of standards for its Health Plan and Health Utilization Management accreditation programs. ... http://www.newscom.com/cgi-bin/prnh/20030501/URACLOGO ) , , These new ...
Cached Medicine News:Health News:Technology Collaborative Launches Online Game to Exercise Brain Power of People with Multiple Sclerosis 2Health News:Technology Collaborative Launches Online Game to Exercise Brain Power of People with Multiple Sclerosis 3Health News:Technology Collaborative Launches Online Game to Exercise Brain Power of People with Multiple Sclerosis 4Health News:PAL Health Technologies Wins State-Level Prestigious 'Employer of the Year' Award 2Health News:2009 National Ergonomics Conference Schedule Announced, Focus on Productivity & Profitability With Reduced Workforces, All Major Sponsors Renew & New Exhibitors Join the Expo 2Health News:Teaming Up to Tackle a Deadly Cancer 2Health News:Teaming Up to Tackle a Deadly Cancer 3Health News:Teaming Up to Tackle a Deadly Cancer 4Health News:Fountain of Life Group, LLC Introduces VaNu 2Go+ 2Health News:URAC Seeks Public Input on New Uniform External Review Standards for Health Plan and Health Utilization Management Organizations 2Health News:URAC Seeks Public Input on New Uniform External Review Standards for Health Plan and Health Utilization Management Organizations 3
(Date:5/4/2015)... , May 4, 2015  Clinical Support Services, ... PharmD, has completed preliminary analysis of Pharmacologic Adverse ... Resources from Clinical Support Services, Inc. clinical staff ... with patients currently taking psychiatric medications to assess ... found that 93% of patients experienced at least ...
(Date:5/4/2015)... 4, 2015 MEI Pharma, Inc. (Nasdaq: ... the clinical development of novel therapies for cancer, ... of the Company,s investigational drug candidate ME-344 in ... combined with a tyrosine-kinase inhibitor (TKI). In addition, ... a potent inhibitor of mitochondrial oxidative phosphorylation (OXPHOS) ...
(Date:5/4/2015)... May 4, 2015  Geneia, a company of ... solutions to improve healthcare efficiencies, today announced a ... Center (BNRC) use Geneia,s advanced analytics solution ... the quality and lower the cost of patient ... outcomes, claims and utilization data from multiple sources ...
Breaking Medicine Technology:Clinical Support Services, Inc. Verifies That Increased Availability of MTM Services Facilitates Identification of Adverse Drug Effects in Psychiatric Patients 2Clinical Support Services, Inc. Verifies That Increased Availability of MTM Services Facilitates Identification of Adverse Drug Effects in Psychiatric Patients 3MEI Pharma's Mitochondrial Inhibitor ME-344 Shows Enhanced Anti-Tumor Activity in Combination with Tyrosine-Kinase Inhibitor in Pre-Clinical Studies 2MEI Pharma's Mitochondrial Inhibitor ME-344 Shows Enhanced Anti-Tumor Activity in Combination with Tyrosine-Kinase Inhibitor in Pre-Clinical Studies 3MEI Pharma's Mitochondrial Inhibitor ME-344 Shows Enhanced Anti-Tumor Activity in Combination with Tyrosine-Kinase Inhibitor in Pre-Clinical Studies 4MEI Pharma's Mitochondrial Inhibitor ME-344 Shows Enhanced Anti-Tumor Activity in Combination with Tyrosine-Kinase Inhibitor in Pre-Clinical Studies 5Geneia Launches First-of-its-Kind Partnership to Use Advanced Analytics to Improve the Quality and Cost of Care for Skilled Nursing and Rehabilitation Patients 2Geneia Launches First-of-its-Kind Partnership to Use Advanced Analytics to Improve the Quality and Cost of Care for Skilled Nursing and Rehabilitation Patients 3
... Md., Dec. 15, 2011  GP Strategies Corporation (NYSE: ... merger of GP Strategies Corporation with and ... current holding company structure. General Physics, which is the ... surviving legal corporation and will be renamed GP Strategies ...
... the industry leader in innovative shape memory orthopedic devices, today ... United States Copyright and Patent Office for its innovative shape ... was granted December 6, 2011 for a "Method and Apparatus ... memory polymers are advanced materials that can "remember" more than ...
Cached Medicine Technology:GP Strategies Shareholders Approve Elimination of Holding Company Structure and Renaming of General Physics Corporation 2GP Strategies Shareholders Approve Elimination of Holding Company Structure and Renaming of General Physics Corporation 3MedShape, Inc. Awarded U.S. Patent for Deploying Shape Memory Polymer Devices in Medical Applications 2
The Biopro All Poly cup is a uniquely designed UHMWPE acetabular cup....
The Plasmacup SC satisfies two important requirements: high primary stability and a low friction bearing surface....
The cementless biomEx cup can be used with both cemented and cementless femoral stems....
The Secur-Fit cups incorporate enhancements derived from years of clinical, radiographic, and implant retrieval observations....
Medicine Products: