Navigation Links
Lack Of Estrogen In Brain Tissue Of Women Can Lead To Alzheimer's

It has been found from autopsy studies that women with Alzheimer’s disease have low levels of the sex hormone estrogen in their brain tissue than women with a sound mental health. // The research has been conducted by Dr. Rena Li and colleges at the University of Chicago.

Previous studies conducted on animal models have already revealed that deficiency of estrogen in the brain tissue can speed up the build up of ‘plaque’, which is a common characteristic of the disease.

An analysis of the serum estrogen levels revealed lower levels of the hormone in both patients with Alzheimer’s and control subjects. Hence no correlation between the serum estrogen levels and the onset of the disease could be identified.

It has therefore been concluded that deficiency of estrogen in the brain rather than blood estrogen deficiency could be more specific in the pathogenesis behind Alzheimer’s. This is supported by the fact that the brain cannot manufacture estrogen.

In order to assess the effect of reduced levels of estrogen in the brain on the onset and severity of the disease, the researchers developed mice that mimicked Alzheimer’s disease through specialized breeding techniques. In addition, it lacked the capacity to synthesize estrogen as well.

Animals that were thus produced had reduced levels of estrogen in the brain and had a much earlier onset of plaque build up. To confirm that brain estrogen levels plays a significant role in the disease process, mice that underwent ovary removal was examined for the development of estrogen deficient brain disease.

As anticipated, only mice with deficient levels of estrogen in the brain developed the disease. The above finding perhaps serves to explain the failure of development of Alzheimer’s in all post-menopausal women. It has further been hypothesized that certain specific genetic mechanisms could be responsible for the observed variability in the onset of the disease.

Most importantly, the results of the present study have highlighted the need for development of an estrogen formulation that can cross the blood brain barrier to be effective against the disease. The research team is currently assessing a number of natural estrogen products for the above-mentioned transport potential.


'"/>




Related medicine news :

1. Estrogen lowers cancer risk
2. Estrogen Does Not Prevent Recurrent Strokes
3. Herbs With Estrogen Action Aggravate Cancer Risk
4. Osteoarthritis and Estrogen are connected
5. Estrogen Patch is Safer than Pills for Heart
6. Estrogen in Food Reduces Cancer Risk
7. Estrogen Found To Protect the Colon Against Cancer
8. The Side Effects Of Estrogen Therapy
9. The Effects Of Estrogen Therapy
10. A Likely Use For Estrogen Therapy
11. Preventing Colon Cancer With Estrogen
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/24/2016)... ... May 24, 2016 , ... ... announced the official relaunch of its community and education hub for women considering ... mission is to create a safe and welcoming place for women to find ...
(Date:5/24/2016)... , ... May 24, 2016 , ... ... appointment of Jonathan (Jon) Otterstatter to its board of directors. Otterstatter ... proven leader in the development of technological innovations that lead to broad-based healthcare ...
(Date:5/24/2016)... ... May 24, 2016 , ... Bio-Logic Aqua® Research Water Life ... and a trainer for Ageless Grace ( http://www.agelessgrace.com ) to discuss healthier lifestyles, ... 16, 2016. , Formerly a Northwestern University Literature Professor, Kinst gravitated to her ...
(Date:5/24/2016)... ... May 24, 2016 , ... Controlling and maintaining the ... the launch of the Aquanta Water Heater Controller , a first-of-its-kind system that ... web-enabled device. As the Nest thermostat does for HVAC systems, Aquanta gives users ...
(Date:5/24/2016)... MA (PRWEB) , ... May 24, 2016 , ... ... Harvard Medical School, today announced a licensing relationship that will deliver a new ... This relationship will put the medical knowledge and expertise of Harvard Medical ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... UAE, May 23, 2016 Experts ... of Precision Medicine and the role of technology ...   The First International Conference of VPS-Penn Medicine ... distinguished patronage and presence of Sheikh Nahyan bin Mubarak Al ... in Precision Medicine, which helps provide personalized medicine and tailor-made ...
(Date:5/23/2016)... 23, 2016 The global  reprocessed ... billion by 2022, according to a new study by ... waste coupled with the lack of centralized support for ... drive the demand for reprocessed medical devices market. Additionally, ... to that of the original device is the high ...
(Date:5/22/2016)... DS Biopharma (DS) today ... compound DS102 in chronic obstructive pulmonary disease (COPD) ... patients. Recent DS preclinical data suggests ... and has bronchodilatory, anti-inflammatory and anti-fibrotic properties in ... will publish further detail on these findings later ...
Breaking Medicine Technology: