Navigation Links
LDH Measurement Can Predict Outlook Of Patients With SCD

Individuals, more specifically adults at risk of developing sickle cell disease related complications could be identified by a simple test // that measures the levels of the enzyme lactate dehydrogenase (LDH). Sickle cell disease is a genetic disorder characterized by sickle shaped red blood cells with compromised oxygen carrying capacity.

Kidney, heart, liver and red blood cells are some rich sources of the enzyme, although trace amounts of the enzyme can be found in other cell types. Under diseased conditions, the cells that contain the enzyme release the same, leading to elevated levels of the enzyme in the same.

The researchers analyzed the LDH levels in over 213 adults, diagnosed with sickle cell disease. The study participants were divided into three groups based on their serum LDH level (high, medium, low). Individuals with high LDH levels (512-1171 IU/L) had a higher incidence of disease related complications such as priapism (persistent painful erections), leg ulcerations and pulmonary hypertension. The severity of the complication could be correlated to the LDH level. Furthermore, the survival rate of those with high LDH levels was comparatively lower than the other two groups.

Following these findings, it has been suggested that a measurement of LDH level can be used to determine the progress of the disease and provide an estimate of the associated complication risk. It can even predict which patients will survive longer.

The correlation of the LDH levels and the disease severity was found to be independent of the standard treatment with hydroxyurea. Vaso-occlusive cries, caused due to the sickle shaped RBC’s obstructing the blood vessels, a hallmark of sickle cell disease were also not found to influence LDH levels. The results of this clinically important study can be found in the latest issue of Blood, a journal published by the American Society of Hematology.

'LDH levels illuminate a pattern of pathology in sickle cell disease patients. This study suggests that LDH testing may be a worthwhile addition to 'well adult' visits for individuals with sickle cell anemia, though the significance in children and adolescents, remains unclear. As a result, LDH appears to hold great promise as an effective indicator for identifying patients most at risk and in need of possible preventive care and careful monitoring,' concluded the researchers.


'"/>




Related medicine news :

1. Study On Self Measurement Of Blood Pressure
2. Childhood Obesity Vs Malnutrition- A Spotlight On WHO Obesity Measurement For Kids
3. Virus Level could Predict Cervical Cancer Risk
4. Long-Term Survival can be Predicted by a Simple Lung Test
5. White Cells Count Can Predict Heart Attack Death Risk
6. Predictable genes
7. Restricted Activity Predicts Disability
8. Fitness Level Predicts Stroke
9. Elevated LDL levels in Childhood could be Predictors of Heart Disease
10. Brain Scans Help Predict Alzheimers Disease
11. Predictors for Type 2 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/17/2017)... ... February 17, 2017 , ... MAP ... today that Karen Pilley has been promoted to Chief Executive Officer. , ... healthcare paradigm – a shift that demands the transition from pay-for-service to pay-for-performance ...
(Date:2/17/2017)... , ... February 17, 2017 , ... ... Chief Executive Officer, George Rogers, was named to Staffing Industry Analysts' 2017 "Staffing ... 100 honors those who have made notable contributions to the staffing industry over ...
(Date:2/17/2017)... (PRWEB) , ... February 17, 2017 , ... Like most ... reduce readmissions. Driven in large part by the Hospital Readmission Reduction Program (HRRP), the ... a key focus area for hospitals across the nation. While many providers are struggling ...
(Date:2/17/2017)... ... February 17, 2017 , ... ... planning assistance to families and business owners in and around the Hampton Roads ... to help prevent all forms of domestic violence. , There are multiple categories ...
(Date:2/16/2017)... ... February 17, 2017 , ... Harsha Chigurupati ... years of research, development and clinical trials, the founder of Chigurupati Technologies has ... compound of FDA approved ingredients that when infused into alcohol, protect the consumer’s ...
Breaking Medicine News(10 mins):
(Date:2/16/2017)... 2017  Newly published research from the CVS Health ... role a private retailer can play in restricting access ... online today in the American Journal of Public ... tobacco from all CVS Pharmacy stores reduced the number ... even greater impact on those who bought cigarettes exclusively ...
(Date:2/16/2017)... Calif. , Feb. 16, 2017  AcelRx ... specialty pharmaceutical company focused on the development and ... moderate-to-severe acute pain, announced that Vincent J. ... and a member of the company,s board of ... brings over two decades of experience leading executive ...
(Date:2/16/2017)... WASHINGTON , Feb. 16, 2017  Prescription pain ... emergency department visit are necessary for long-term opioid use ... the Feb. 16 th edition of The ... "Emergency physicians see more patients in acute pain ... Rebecca Parker , MD, FACEP, president of the American ...
Breaking Medicine Technology: