Navigation Links
LDH Measurement Can Predict Outlook Of Patients With SCD

Individuals, more specifically adults at risk of developing sickle cell disease related complications could be identified by a simple test // that measures the levels of the enzyme lactate dehydrogenase (LDH). Sickle cell disease is a genetic disorder characterized by sickle shaped red blood cells with compromised oxygen carrying capacity.

Kidney, heart, liver and red blood cells are some rich sources of the enzyme, although trace amounts of the enzyme can be found in other cell types. Under diseased conditions, the cells that contain the enzyme release the same, leading to elevated levels of the enzyme in the same.

The researchers analyzed the LDH levels in over 213 adults, diagnosed with sickle cell disease. The study participants were divided into three groups based on their serum LDH level (high, medium, low). Individuals with high LDH levels (512-1171 IU/L) had a higher incidence of disease related complications such as priapism (persistent painful erections), leg ulcerations and pulmonary hypertension. The severity of the complication could be correlated to the LDH level. Furthermore, the survival rate of those with high LDH levels was comparatively lower than the other two groups.

Following these findings, it has been suggested that a measurement of LDH level can be used to determine the progress of the disease and provide an estimate of the associated complication risk. It can even predict which patients will survive longer.

The correlation of the LDH levels and the disease severity was found to be independent of the standard treatment with hydroxyurea. Vaso-occlusive cries, caused due to the sickle shaped RBC’s obstructing the blood vessels, a hallmark of sickle cell disease were also not found to influence LDH levels. The results of this clinically important study can be found in the latest issue of Blood, a journal published by the American Society of Hematology.

'LDH levels illuminate a pattern of pathology in sickle cell disease patients. This study suggests that LDH testing may be a worthwhile addition to 'well adult' visits for individuals with sickle cell anemia, though the significance in children and adolescents, remains unclear. As a result, LDH appears to hold great promise as an effective indicator for identifying patients most at risk and in need of possible preventive care and careful monitoring,' concluded the researchers.


'"/>




Related medicine news :

1. Study On Self Measurement Of Blood Pressure
2. Childhood Obesity Vs Malnutrition- A Spotlight On WHO Obesity Measurement For Kids
3. Virus Level could Predict Cervical Cancer Risk
4. Long-Term Survival can be Predicted by a Simple Lung Test
5. White Cells Count Can Predict Heart Attack Death Risk
6. Predictable genes
7. Restricted Activity Predicts Disability
8. Fitness Level Predicts Stroke
9. Elevated LDL levels in Childhood could be Predictors of Heart Disease
10. Brain Scans Help Predict Alzheimers Disease
11. Predictors for Type 2 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... ... a legally blind and certified personal trainer is helping to develop a weight loss fitness ... to fix the two major problems leading the fitness industry today:, , ... They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX ... Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over ... Cut Pro X . Simply select a ProHand generator and drag it above media ...
(Date:6/25/2016)... Montreal, Canada (PRWEB) , ... June 25, 2016 , ... ... the pursuit of success. In terms of the latter, setting the bar too high ... low, risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Sessions in Dallas that it will receive two significant new grants to support ... as PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. ... magazine’s Code Talker Award, an essay contest in which patients and their families pay ... be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Roche (SIX: ... 510(k) clearance for its Elecsys BRAHMS PCT (procalcitonin) assay ... sepsis or septic shock. With this clearance, Roche is ... a fully integrated solution for sepsis risk assessment and ... with bacterial infection and PCT levels in blood can ...
(Date:6/23/2016)... June 23, 2016 , , ... July 7, 2016 , , , , LOCATION: , , ... , , , EXPERT PANELISTS:  , , , Frost & ... Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, ... The global pharmaceutical industry is witnessing an exceptional era. Several new ...
(Date:6/23/2016)... June 23, 2016 The vast majority of ... dialysis facility.  Treatments are usually 3 times a week, ... visit, including travel time, equipment preparation and wait time. ... especially grueling for patients who are elderly and frail.  ... nursing and rehabilitation centers for some duration of time. ...
Breaking Medicine Technology: