Navigation Links
Knocking Out Survival Protein Could Fight Leukemia

An effective way to fight leukemia might be to knock out a specific protein that protects cancer cells from dying, a new study shows// .

The findings suggest that a drug that can block this “survival protein” might on its own be an effective therapy.

But such a drug used in combination with several existing drugs might also offer an effective one-two punch against drug-resistant forms of chronic lymphocytic leukemia (CLL) and acute lymphoblastic leukemia (ALL). The two forms of cancer kill about 20,500 Americans yearly.

The survival protein is called Mcl1. It usually helps keep normal cells healthy and is involved in the development of the components of the immune system, but it can also help prolong survival of cancer cells.

Cells with an overabundance of the protein are also more resistant to anticancer drugs such as rituximab, which has revolutionized the treatment of certain chronic and acute leukemias.

The study by researchers at the Ohio State University Comprehensive Cancer Center is published online in the journal Clinical Cancer Research.

“Our findings demonstrate that Mcl1 may be an effective target for drugs directed against CLL and ALL,” says principal investigator John C. Byrd, professor of internal medicine and director of the hematologic malignancies program at Ohio State's James Cancer Hospital and Solove Research Institute.

“These results give us a rationale for lowering the amount of this protein in CLL cells and suggest that this should enhance the action of rituximab and perhaps other agents as well.”

Rituximab is an antibody-based drug that targets CLL and ALL cells and causes the cells to self-destruct.

“We've shown that knocking down Mcl1 can, by itself, cause CLL cells to die, and that this effect might enhance the activity of rituximab,” says first author Rehan Hussain, a postdoctoral fellow with Ohio State's Comprehensive Canc
'"/>




Page: 1 2

Related medicine news :

1. Knocking Out Survival Protein Could Aid Leukemia Treatment
2. Long-Term Survival can be Predicted by a Simple Lung Test
3. Hepatitis G May Boost HIV Survival
4. Survival rates in breast cancer patients improved with "Dose Dense Chemotherapy"
5. Longer Lung Cancer Survival
6. ICU Survival can be improved by Antibiotic use
7. Vasopressin Found To Boost Survival In Sudden Cardiac arrest
8. Improving Survival Rate Of Lung Cancer Patients
9. Combination Therapy Effective In Improving Lung Cancer Survival
10. Symptoms Found To Be A Good Predictor Of Cancer Survival
11. Survival Of Colon Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Knocking Out Survival Protein Could Fight Leukemia

(Date:5/22/2015)... Lehi, Utah (PRWEB) May 22, 2015 Mountain ... will host a ribbon cutting ceremony on Friday, May 29, ... 1 p.m. to 6 p.m. The new medical center, set ... 3000 North Triumph Boulevard, Lehi, UT 84043. , “The ... for our team and the Utah County community,” said Kent ...
(Date:5/22/2015)... May 22, 2015 Following yesterday’s announcement ... agreement with US-based health brand Nature’s Way, Marc St-Onge ... Retention of Ascenta Skin is an integral part of ... about this opportunity to further develop Ascenta Skin into ... Ascenta Skin is a breakthrough, anti-aging skincare supplement featuring ...
(Date:5/22/2015)... Hands On HealthCare Massage Therapy and ... Annual One Day Sale on Massage and Facial ... offers drastically reduced certificates one day a year. This sale ... through what used to be the slowest time of the ... as well. This once a year occurrence has become a ...
(Date:5/22/2015)... Carnegie Science Center and Allegheny ... to develop BodyTech, a dynamic, three-pronged health and science ... new exhibit at the Science Center called BodyWorks, the ... traveling science show, Anatomy Adventure, which will hit the ... to explore a wide range of topics surrounding health ...
(Date:5/22/2015)... According to a new Aegis Living Study on Attitudes ... to worry about what will happen to their memory as ... Silent Generation), which may help explain why nearly half of ... Millennials (47%), Gen X’ers (51%), and Boomers (43%). The study ... more than 2,000 U.S. adults ages 18+. , “This ...
Breaking Medicine News(10 mins):Health News:Mountain Point Medical Center, a Campus of Jordan Valley Medical Center, Hosts Ribbon Cutting Ceremony and Community Celebration on Friday, May 29, 2015 2Health News:Ascenta Skin President Announces Plans to Grow Brand 2Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Announces Their Eighth Annual One Day Sale on Gift Certificates Will Take Place on June 17, 2015 2Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Announces Their Eighth Annual One Day Sale on Gift Certificates Will Take Place on June 17, 2015 3Health News:Carnegie Science Center, Allegheny Health Network Partner to Create BodyTech 2Health News:Carnegie Science Center, Allegheny Health Network Partner to Create BodyTech 3Health News:Carnegie Science Center, Allegheny Health Network Partner to Create BodyTech 4Health News:New Study Reveals America’s Fear of Aging 2Health News:New Study Reveals America’s Fear of Aging 3
... as a key resource for finding the best Government and nonprofit ... straightforward and credible information catalogued on the site. But it is ... for disease prevention and wellness information interactive and action oriented. ... ...
... Amoena, the worldwide leader of post-breast surgery ... Hannah Collection, the industry,s first post-surgical garments ... ease discomfort after breast surgery.(Logo: ... http://www.newscom.com/cgi-bin/prnh/20090408/CL96087 )The post-surgical camisole ...
... ORTHOCON¿ Inc. today announced that Paul R. Sohmer, ... Executive Officer. The company also announced the closing of ... healthcare investors. ORTHOCON is developing innovative implantable devices ... platform may be leveraged to deliver a variety of ...
... high marks on intentions for good nutrition but lack ... no surprise that with the current economic conditions, three-quarters ... healthy eating is largely dependent on what food families ... family pantries, fridges, and freezers, Rutgers University ...
... 8 Cordex Pharma, Inc. (OTC Bulletin Board: CDXP) ... BG Medicine (BGM) in its Phase 2 clinical safety ... this collaboration, BGM will measure levels of Galectin-3 in ... for cardiac remodeling associated with advanced stages of heart ...
... April 8 The College of American Pathologists (CAP), ... and deeming authority under the Clinical Laboratory Improvement Amendments ... Services (CMS) since 1995, has been notified that it ... a six-year period, the longest period available for this ...
Cached Medicine News:Health News:healthfinder.gov Adds New Interactive Features to Its Web Site 2Health News:Amoena Introduces First Post Surgical Garments With Vitamin E & Aloe to Help Soothe and Comfort After Breast Surgery 2Health News:ORTHOCON Announces Appointment of New CEO and $25 Million Series B Financing 2Health News:Rutgers Study Reveals A Need For Basic Kitchen Know-How 2Health News:Rutgers Study Reveals A Need For Basic Kitchen Know-How 3Health News:Cordex Pharma to Collaborate with BG Medicine in a Clinical Study of Heart Failure Biomarkers 2Health News:Cordex Pharma to Collaborate with BG Medicine in a Clinical Study of Heart Failure Biomarkers 3Health News:Cordex Pharma to Collaborate with BG Medicine in a Clinical Study of Heart Failure Biomarkers 4Health News:CAP Deeming Status Renewed 2
(Date:5/22/2015)... PRUSSIA, Pa. , May 22, 2015  The ... its 2015 Corporate Leadership Award as recognition for the ... the care of the bleeding disorders community.  The award was ... CSL Limited, during the NHF Annual Spring Soiree in ... "The National Hemophilia Foundation is dedicated to finding better ...
(Date:5/22/2015)... 2015   InspireMD, Inc. (NYSE MKT: NSPR) ("InspireMD" ... ("EPS"), today announced that its CGuard TM Embolic Prevention ... Prof. Piotr Musialek , at the EuroPCR ... . PARADIGM, an investigator-initiated P rospective ... roti D revascularization I n symptomatic and increased-risk ...
(Date:5/22/2015)... , May 22, 2015 AcelRx Pharmaceuticals, ... focused on the development and commercialization of innovative therapies ... announced that interim chief executive officer Howie Rosen ... and chief financial officer Tim Morris will ... of the two presentations are as follows: ...
Breaking Medicine Technology:National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 2National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 3National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 4InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 2InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 3InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 4AcelRx Pharmaceuticals to Present at Two Upcoming Investor Conferences In June 2
... of the spine. Comfortable support ... provided for all body types ... in both superior and inferior ... be positioned for a wide ...
Adjust-A-Tip cautery....
6 mm, 45 degree upwards, detachable....
Sabre 180 is a powerful niche generator....
Medicine Products: