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Knee Osteoarthritis May Be Triggered By Low Levels Of Estrogen

mportant role in this pathway.

Previous studies have shown that altered patterns of estrogen metabolism are present in rheumatoid arthritis and systemic lupus erythematosus, suggesting an association with symptoms, such as pain and inflammation, as opposed to disease onset and progression due to structural changes. The authors note that although the 2-hydroxyestrone levels in those with knee OA were significantly lower than in those without the disease, "more detailed investigation is required to establish if primary pathways are associated with symptoms, duration of symptoms, symptom severity, or with response in cartilage and bone."

Given the strong associations of lower estradiol and 2-hydroxyestrone levels with more knee OA, the authors conclude: "If findings are confirmed, then this helps motivate new areas of investigation for intervention. If the mechanistic explanation of 2-hydroxyestrone levels lies, at least in part, in arachidonic acid metabolism associated with pain and inflammation rather than receptor binding, then considering alternative lifestyle and therapeutic pathways to influence these metabolites becomes increasingly viable."

Contact: Amy Molnar amolnar@wiley.com John Wiley & Sons, Inc. Source: Eurekalert
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