Navigation Links
Knee Osteoarthritis May Be Triggered By Low Levels Of Estrogen

Women in the age of 40 to 50 years are more prone to osteoarthritis. Researchers thing that sex hormones may play a vital role in the disease because of the inflammation caused in the condition as it worsens.//

A new study has examined the role played by estradiol, the main sex hormone estrogen in premenopausal and early perimenopausal women and how it works in the development of osteoarthritis. The findings appear in the August 2006 issue of Arthritis & Rheumatism (http://www.interscience.wiley.com/journal/arthritis).

Led by MaryFran R. Sowers of the University of Michigan in Ann Arbor, MI, the study included 842 premenopausal or perimenopausal women from the Southeast Michigan Arthritis Cohort. The women had annual X-rays of both knees along with analysis of blood levels of estradiol and urine levels of 2-hydroxyestrone and 16á-hydroxyestrone, two estrogen metabolites. Patients were also interviewed regarding pain, health, and lifestyle and were followed for three years. The results showed that the women who developed knee OA during the study period had greater odds of having estradiol concentrations and urinary 2-hydroxyestrone levels in the lowest third of the study population, and a higher ratio of 2-hydroxyestrone to 16á-hydroxyestrone, even after adjusting for other risk factors.

"Selected work with animal models provides support for the increased odds of developing OA with lower estradiol concentrations," the authors note. This is one of the few studies that has actually examined hormone concentrations, particularly in relation to new cases of OA, and the first to examine levels of estrogen metabolites. The authors hypothesize that the role of higher 2-hydroxyestrone concentrations in delaying the development of knee OA may be partially through the metabolism of arachidonic acid, a compound from which cells involved in inflammation (such as leukotrienes) are produced, since estrogen metabolites have been shown to play an i mportant role in this pathway.

Previous studies have shown that altered patterns of estrogen metabolism are present in rheumatoid arthritis and systemic lupus erythematosus, suggesting an association with symptoms, such as pain and inflammation, as opposed to disease onset and progression due to structural changes. The authors note that although the 2-hydroxyestrone levels in those with knee OA were significantly lower than in those without the disease, "more detailed investigation is required to establish if primary pathways are associated with symptoms, duration of symptoms, symptom severity, or with response in cartilage and bone."

Given the strong associations of lower estradiol and 2-hydroxyestrone levels with more knee OA, the authors conclude: "If findings are confirmed, then this helps motivate new areas of investigation for intervention. If the mechanistic explanation of 2-hydroxyestrone levels lies, at least in part, in arachidonic acid metabolism associated with pain and inflammation rather than receptor binding, then considering alternative lifestyle and therapeutic pathways to influence these metabolites becomes increasingly viable."

Contact: Amy Molnar amolnar@wiley.com John Wiley & Sons, Inc. Source: Eurekalert
'"/>




Related medicine news :

1. New device for discerning Osteoarthritis
2. Osteoarthritis and Estrogen are connected
3. Hyaluronan supplementation therapy for Knee Osteoarthritis
4. Leech Therapy for Osteoarthritis
5. Hydrotherapy Found to be Effective for Patients with Osteoarthritis
6. Hydrotherapy Found to be Effective for Patients with Osteoarthritis
7. Pain Relief For Osteoarthritis Patients
8. The Use Of Ointments For The Treatment Of Osteoarthritis Questioned
9. New Drug Found To Benefit Patients With Osteoarthritis
10. Water Exercise Found to be Effective for Patients with Osteoarthritis
11. Hydrotherapy Could Be Effective For Osteoarthritis
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/7/2016)... ... February 07, 2016 , ... HealthSmart Holdings, ... and organizations with the tools and information to lower the costs, and increase ... the cost of providing employee healthcare benefits by as much as 22%:, + ...
(Date:2/7/2016)... Scottsdale, AZ (PRWEB) , ... February 07, 2016 ... ... & Neck and Facial Plastics, has added Kybella® to his medical and surgical ... is a newly approved FDA injectable medication used as a non-surgical alternative for ...
(Date:2/6/2016)... , ... February 06, 2016 ... ... 303-368-6225 , MEDIA ADVISORY: 5000 PERIOPERATIVE NURSES EXPECTED AT AORN SURGICAL CONFERENCE ... perioperative nurses in the world with an estimated 5000 perioperative nurses in ...
(Date:2/6/2016)... ... February 06, 2016 , ... US Sports Camps is ... (YUCC) . This event brings together top non-profit leaders, ultimate organizations, and coaches from ... Ultimate”. Valerio Iani, Bay Area Disc Program Director of Youth and Education, describes this ...
(Date:2/6/2016)... Viejo, CA (PRWEB) , ... February 06, 2016 , ... ... quickly and easily add warm color grades to their footage. A LUT is a ... every pixel's color to the corresponding color indicated by the table. By manipulating each ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... , Feb. 5, 2016  Patients in Alabama ... focused ultrasound (HIFU) therapy no longer have to travel out ... its partnership with Urology Centers of Alabama to ... FDA-cleared procedure for qualifying patients. Alabama ... in the treatment of prostate cancer using many different modalities. ...
(Date:2/5/2016)... 5, 2016 Aethlon Medical, Inc. (Nasdaq: AEMD ... CEO, will be presenting at Source Capital Group,s 2016 Disruptive ... at 2:15 p.m. ET on Wednesday, February 10, ... discussion taking place at 3:15 p.m. ET. http://www.aethlonmedical.com ... hour after the conclusion of the live event. The panel ...
(Date:2/5/2016)... 5, 2016 Dehaier Medical Systems Ltd. ... "Company"), which develops, markets and sells medical devices ... China and international markets, today announced ... to concentrate the Company,s resources to develop its ... and to focus more on its major businesses. ...
Breaking Medicine Technology: