Navigation Links
Knee Osteoarthritis May Be Triggered By Low Levels Of Estrogen

Women in the age of 40 to 50 years are more prone to osteoarthritis. Researchers thing that sex hormones may play a vital role in the disease because of the inflammation caused in the condition as it worsens.//

A new study has examined the role played by estradiol, the main sex hormone estrogen in premenopausal and early perimenopausal women and how it works in the development of osteoarthritis. The findings appear in the August 2006 issue of Arthritis & Rheumatism (http://www.interscience.wiley.com/journal/arthritis).

Led by MaryFran R. Sowers of the University of Michigan in Ann Arbor, MI, the study included 842 premenopausal or perimenopausal women from the Southeast Michigan Arthritis Cohort. The women had annual X-rays of both knees along with analysis of blood levels of estradiol and urine levels of 2-hydroxyestrone and 16á-hydroxyestrone, two estrogen metabolites. Patients were also interviewed regarding pain, health, and lifestyle and were followed for three years. The results showed that the women who developed knee OA during the study period had greater odds of having estradiol concentrations and urinary 2-hydroxyestrone levels in the lowest third of the study population, and a higher ratio of 2-hydroxyestrone to 16á-hydroxyestrone, even after adjusting for other risk factors.

"Selected work with animal models provides support for the increased odds of developing OA with lower estradiol concentrations," the authors note. This is one of the few studies that has actually examined hormone concentrations, particularly in relation to new cases of OA, and the first to examine levels of estrogen metabolites. The authors hypothesize that the role of higher 2-hydroxyestrone concentrations in delaying the development of knee OA may be partially through the metabolism of arachidonic acid, a compound from which cells involved in inflammation (such as leukotrienes) are produced, since estrogen metabolites have been shown to play an i mportant role in this pathway.

Previous studies have shown that altered patterns of estrogen metabolism are present in rheumatoid arthritis and systemic lupus erythematosus, suggesting an association with symptoms, such as pain and inflammation, as opposed to disease onset and progression due to structural changes. The authors note that although the 2-hydroxyestrone levels in those with knee OA were significantly lower than in those without the disease, "more detailed investigation is required to establish if primary pathways are associated with symptoms, duration of symptoms, symptom severity, or with response in cartilage and bone."

Given the strong associations of lower estradiol and 2-hydroxyestrone levels with more knee OA, the authors conclude: "If findings are confirmed, then this helps motivate new areas of investigation for intervention. If the mechanistic explanation of 2-hydroxyestrone levels lies, at least in part, in arachidonic acid metabolism associated with pain and inflammation rather than receptor binding, then considering alternative lifestyle and therapeutic pathways to influence these metabolites becomes increasingly viable."

Contact: Amy Molnar amolnar@wiley.com John Wiley & Sons, Inc. Source: Eurekalert
'"/>




Related medicine news :

1. New device for discerning Osteoarthritis
2. Osteoarthritis and Estrogen are connected
3. Hyaluronan supplementation therapy for Knee Osteoarthritis
4. Leech Therapy for Osteoarthritis
5. Hydrotherapy Found to be Effective for Patients with Osteoarthritis
6. Hydrotherapy Found to be Effective for Patients with Osteoarthritis
7. Pain Relief For Osteoarthritis Patients
8. The Use Of Ointments For The Treatment Of Osteoarthritis Questioned
9. New Drug Found To Benefit Patients With Osteoarthritis
10. Water Exercise Found to be Effective for Patients with Osteoarthritis
11. Hydrotherapy Could Be Effective For Osteoarthritis
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... ... communities in the greater Dallas, Miami, and Raleigh regions, is organizing an extended ... overcome a rare and deadly chromosome abnormality. , After struggling since birth with ...
(Date:10/13/2017)... ... 13, 2017 , ... The International Association of Eating Disorders ... for the field of eating disorders, announces the opening of early registration for ... Florida at the Omni Resort at ChampionsGate. , The annual iaedp™ ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Many families ... However, many long-term care insurance companies have a waiver for care if the client ... elimination period, when the family pays for care, is often waived, so the benefits ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor ... on sciatica in a new episode of "Success Files," which is an award-winning ... innovation and investigates each subject in-depth with passion and integrity. , Sciatica occurs ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and ... apnea using cutting-edge Oventus O2Vent technology. As many as 18 million Americans ... frequent cessation in breathing. Oral appliances can offer significant relief to about 75 ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... 27, 2017  Commended for their devotion to personalized service, ... as number one in the South Florida Business Journal,s 50 ... 5000 yearly list, the national specialty pharmacy has found its ... will soon be honored by SFBJ as the 2017 ... Set to receive his award in October, Bardisa said ...
(Date:9/25/2017)... 2017  EpiVax, Inc., a leader in the ... today announced the launch of EpiVax Oncology Inc., ... therapeutic cancer vaccines. EpiVax has provided $500,000 in ... enabling technologies to the new precision immunotherapy venture. ... Oncology as Chief Executive Officer. Gad brings over ...
(Date:9/22/2017)... , Sept. 22, 2017 AVACEN Medical (AVACEN) ... is now successfully helping those with the widespread pain ... Fibromyalgia diagnosed Amanda in Essex, England ... washing my hair, experiencing no sleep at all, tremendous ... spasm… I cannot recommend [the AVACEN 100] enough, how ...
Breaking Medicine Technology: