Navigation Links
Knee Osteoarthritis May Be Triggered By Low Levels Of Estrogen

Women in the age of 40 to 50 years are more prone to osteoarthritis. Researchers thing that sex hormones may play a vital role in the disease because of the inflammation caused in the condition as it worsens.//

A new study has examined the role played by estradiol, the main sex hormone estrogen in premenopausal and early perimenopausal women and how it works in the development of osteoarthritis. The findings appear in the August 2006 issue of Arthritis & Rheumatism (http://www.interscience.wiley.com/journal/arthritis).

Led by MaryFran R. Sowers of the University of Michigan in Ann Arbor, MI, the study included 842 premenopausal or perimenopausal women from the Southeast Michigan Arthritis Cohort. The women had annual X-rays of both knees along with analysis of blood levels of estradiol and urine levels of 2-hydroxyestrone and 16á-hydroxyestrone, two estrogen metabolites. Patients were also interviewed regarding pain, health, and lifestyle and were followed for three years. The results showed that the women who developed knee OA during the study period had greater odds of having estradiol concentrations and urinary 2-hydroxyestrone levels in the lowest third of the study population, and a higher ratio of 2-hydroxyestrone to 16á-hydroxyestrone, even after adjusting for other risk factors.

"Selected work with animal models provides support for the increased odds of developing OA with lower estradiol concentrations," the authors note. This is one of the few studies that has actually examined hormone concentrations, particularly in relation to new cases of OA, and the first to examine levels of estrogen metabolites. The authors hypothesize that the role of higher 2-hydroxyestrone concentrations in delaying the development of knee OA may be partially through the metabolism of arachidonic acid, a compound from which cells involved in inflammation (such as leukotrienes) are produced, since estrogen metabolites have been shown to play an i
'"/>




Page: 1 2

Related medicine news :

1. New device for discerning Osteoarthritis
2. Osteoarthritis and Estrogen are connected
3. Hyaluronan supplementation therapy for Knee Osteoarthritis
4. Leech Therapy for Osteoarthritis
5. Hydrotherapy Found to be Effective for Patients with Osteoarthritis
6. Hydrotherapy Found to be Effective for Patients with Osteoarthritis
7. Pain Relief For Osteoarthritis Patients
8. The Use Of Ointments For The Treatment Of Osteoarthritis Questioned
9. New Drug Found To Benefit Patients With Osteoarthritis
10. Water Exercise Found to be Effective for Patients with Osteoarthritis
11. Hydrotherapy Could Be Effective For Osteoarthritis
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Knee Osteoarthritis May Triggered Low Levels Estrogen

(Date:4/18/2014)... WA April 18, 2014) Benaroya Research Institute ... research how blocking a particular molecule in metastatic breast ... the number of lung metastases. BRI scientists have found ... can shrink tumors by 60 - 80 percent and ... the lung. The $1.8 million five-year grant comes from ...
(Date:4/17/2014)... of chronic inflammation in benign prostate tissue was ... this association was found even in those with ... study published in Cancer Epidemiology, Biomarkers & ... for Cancer Research. , An analysis of prostate ... placebo arm of the Prostate Cancer Prevention Trial ...
(Date:4/17/2014)... PLOS Pathogens , children who live in regions of ... immune response to infection with malaria parasites that may ... and illness and partially control the growth of malaria ... develop future interventions that prevent or mitigate the disease ... 200 million cases of malaria occur worldwide, resulting in ...
(Date:4/17/2014)... Le Bonheur Children,s Hospital Pediatrician-in-Chief Jon McCullers, MD, ... the April issue of Nature Reviews Microbiology ... Dr. McCullers, a world-renowned infectious disease specialist, ... the University of Tennessee Health Science Center, analyzed ... 1918, 1957 and 1968 pandemics, as well as ...
(Date:4/17/2014)... The cause of neuronal death in Parkinson,s disease is ... may be mistaken for foreign invaders and killed by ... autoimmune diseases like type I diabetes, celiac disease, and ... published April 16, 2014, in Nature Communications . ... in Parkinson,s disease; but if true, it could lead ...
Breaking Medicine News(10 mins):Health News:Benaroya Research Institute evaluates immunology approach to blocking breast cancer 2Health News:Chronic inflammation may be linked to aggressive prostate cancer 2Health News:Chronic inflammation may be linked to aggressive prostate cancer 3Health News:Study sheds light on how the immune system protects children from malaria 2Health News:Is Parkinson's an autoimmune disease? 2
... Increased Bystander CPR, Faster Patient-to-Doctor Time,Data Collection ... WASHINGTON, Nov. 7 A new ... American College of Emergency Physicians (ACEP) finds,an ... physicians surveyed,believe that resuscitation practices in the ...
... highlighted in several podium,presentations at American Society ... Fla., Nov. 7 Reliant Technologies, Inc., ... of aesthetic laser skin,treatments, today announced that ... fractional laser technology will be presented at ...
... of national and local election coverage with 99.99% ... ... in America.,Millions of Americans eagerly watched news reports, exit polls, and,election ... national networks, including 3 all-news networks and local stations,across the country, ...
... Labopharm Inc. (TSX: DDS;,NASDAQ: DDSS) today announced that ... of Directors of the Company to fill the ... who has stepped down for personal,reasons. Ms. Selisker ... the,Audit Committee. Ms. Selisker, a Certified Public Accountant, ...
... 37% over same quarter in Fiscal 2008 -, ... otherwise noted) BELLEVILLE, ON, Nov. 7 /PRNewswire-FirstCall/ ... technology-driven Canadian,biopharmaceutical company, today announced financial results for ... September 30, 2008., "Our revenues are up ...
... PHILADELPHIA, Nov. 7 One Million Dollars. That,s what,Philadelphia ... his,favorite charity. But here,s the kicker: Akers needs to ... an NFL record that,s stood for the past 38,years., ... current point leader,accepted the challenge from Beachbody, maker of ...
Cached Medicine News:Health News:Emergency Physicians Reveal Strategies for Improving Sudden Cardiac Arrest Survival Rates in the U.S. 2Health News:Emergency Physicians Reveal Strategies for Improving Sudden Cardiac Arrest Survival Rates in the U.S. 3Health News:Fraxel(R) Laser Systems Shown to Provide Superior Results Compared to 'Pseudo Fractional' Laser Technologies 2Health News:Fraxel(R) Laser Systems Shown to Provide Superior Results Compared to 'Pseudo Fractional' Laser Technologies 3Health News:Fraxel(R) Laser Systems Shown to Provide Superior Results Compared to 'Pseudo Fractional' Laser Technologies 4Health News:Flawless Captioning Service Brings Obama Victory and Speech to Deaf and Hard-Of-Hearing Viewers 2Health News:Bioniche Reports Fiscal 2009 First Quarter 2Health News:Bioniche Reports Fiscal 2009 First Quarter 3Health News:Bioniche Reports Fiscal 2009 First Quarter 4Health News:Bioniche Reports Fiscal 2009 First Quarter 5Health News:Bioniche Reports Fiscal 2009 First Quarter 6Health News:Bioniche Reports Fiscal 2009 First Quarter 7Health News:Bioniche Reports Fiscal 2009 First Quarter 8Health News:Bioniche Reports Fiscal 2009 First Quarter 9Health News:Bioniche Reports Fiscal 2009 First Quarter 10Health News:Bioniche Reports Fiscal 2009 First Quarter 11Health News:Bioniche Reports Fiscal 2009 First Quarter 12Health News:KICKING FOR A CAUSE: Beachbody Pledges $1 million if Akers Breaks NFL Longest Field Goal 2
(Date:1/15/2014)... WORTH, Texas , Jan. 15, 2014  Humberto C. ... Dermatology Achievement Award" from the Journal of Drugs ... Aesthetic & Clinical Conference (ODAC). The event is January 17-20, ... Florida . The ODAC ...
(Date:1/15/2014)... 15, 2014 Tegra Medical is very pleased to announce ... its new Chief Executive Officer.  Mark was promoted from his ... overseen the company,s four facilities in Massachusetts ... King joined Tegra Medical in 2012 with 20+ years of ...
(Date:1/15/2014)...  According to Millennium Research Group (MRG), the global ... the United States and European transcatheter ... moderately through 2022, with embolization particles representing one ... in drug-eluting beads (DEBs) and radioembolization spheres in ...
Breaking Medicine Technology:Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 2Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 4Tegra Medical Appoints New Chief Executive Officer 2Tegra Medical Appoints New Chief Executive Officer 3US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 3
... The VersaPulse PowerSuite holmium laser ... properties for precise, virtually bloodless procedures. ... fragmenting urinary and gall bladder stones ... ideal multipurpose surgical tool. Because its ...
... VersaPulse PowerSuite holmium laser combines excellent ... precise, virtually bloodless procedures. It is ... and gall bladder stones of all ... surgical tool. Because its laser light ...
... laser combines excellent cutting, ablation and ... procedures. It is also extremely effective ... stones of all compositions, making it ... its laser light is transmitted through ...
... The UltraPulse system's capability to quickly deliver ... one pulse allows for powerful single-pulse ablation. ... UltraPulse system the coldest and cleanest CO2 ... power is combined with the independent adjustment ...
Medicine Products: