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Key Mechanism to Emergence of Strep Bacteria

as is seen in necrotizing fasciitis and other severe forms of strep infection, said Walker.

The research team used genetically engineered mice expressing human plasminogen and infected them with M1T1 strep clone, discovering that the bacteria routinely mutated to the invasive form, then spread throughout the body to produce a fatal infection.

When the researchers eliminated the single bacteriophage gene encoding the neutrophil resistance factor, the M1T1 strep strain lost its ability to undergo the dangerous mutation and could no longer spread to produce severe infection.

Ancestral strains of the M1T1 strep, isolated before the acquisition of the bacteriophage, also failed to undergo the mutation to produce serious disease.


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