Navigation Links
Key Found to Kill Cystic Fibrosis Superbug

Researchers from the Schulich School of Medicine & Dentistry at The University of Western Ontario , working with a group from Edinburgh//, have discovered a way to kill the cystic fibrosis superbug , Burkholderia cenocepacia. These investigators, under the leadership of Dr. Miguel Valvano, Department of Microbiology and Immunology, have had their research published in the May issue of the Journal of Bacteriology, and highlighted in Nature Reviews/Microbiology.

B. cenocepacia is a multi-drug resistant microorganism that lives in damp or wet places and causes rot in plants such as onions. While it rarely causes infection in healthy people, it can be fatal for people with cystic fibrosis (CF), an inherited disease where the lungs become clogged with thick mucus, often leading to chronic respiratory infections.

The team of researchers has identified a weakness in the armour that protects the B. cenocepacia bacterium from the effects of antibiotics. They hypothesize that preventing the synthesis of a key sugar required for this armour, 4-amino-4-deoxy-L-arabinose (Ara4N), may lead to a susceptibility within the cell membrane to antibiotics.

"We are very excited with these findings, as they will let us come up with novel molecules to disrupt the making of Ara4N," says Valvano. "These molecules could then be tested as novel antibiotics." Valvano is a Professor and Chair of the Department of Microbiology and Immunology, a Canada Research Chair in Infectious Diseases and Microbial Pathogenesis, and leader of the Infectious Diseases Research Group at the Siebens-Drake Research Institute. He is available for interviews.

The research was funded through the Canadian Cystic Fibrosis Foundation and the Canadian Institutes of Health Research (CIHR). "We're delighted by this news," says Cathleen Morrison, CEO of the Canadian Cystic Fibrosis Foundation. "The possibility of a life-saving antibiotic to fight B. cenocepacia is tremendously encouraging to adults and children who have cystic fibrosis."

Dr. Bhagirath Singh, Scientific Director of the CIHR Institute of Infection and Immunity, says "This discovery provides new hope for the eradication of these bugs from cystic fibrosis patients and to improve their quality of life by developing new treatments."

Source-Eurekalert/B
'"/>




Related medicine news :

1. Fluoride Found Effective in Osteoporosis
2. Implantable Contact Lens Found Safe and Effective
3. Cancer hazard Found With Animal-Based Nutrients
4. Processed Meat, Diabetes connection Found
5. Night Time Aspirin Regimen Found to Reduce Blood Pressure
6. Hydrotherapy Found to be Effective for Patients with Osteoarthritis
7. Hydrotherapy Found to be Effective for Patients with Osteoarthritis
8. Preventive Therapies Found to be More Effective in Managing Migraines
9. Common Cold Found to Fight Cancer
10. Circumcision Found To Prevent HIV Spread
11. Drug Found To Reduce The Transmission Of Herpes
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2016)... ... May 26, 2016 , ... In an effort to provide hair restoration information to the widest ... and those who do not use the app. Dr. Mohebi, the founder of Parsa Mohebi ... Mohebi Live . , Dr. Mohebi says, “The positive response to the Snapchat videos ...
(Date:5/26/2016)... Indiana (PRWEB) , ... May 26, 2016 , ... ... provider of healthcare supply chain solutions, today announced the organization has earned its ... meets international standards and is compliant with all rules and policies associated with ...
(Date:5/26/2016)... ... May 26, 2016 , ... The Lung Institute ... six-week smoking cessation class starting June 6 at their clinic in downtown Tampa. The ... , Additionally, the Lung Institute has created a free downloadable 4 Week Smoking ...
(Date:5/26/2016)... Rafael, CA (PRWEB) , ... May 26, 2016 ... ... will be offering campers a multitude of activities from daily practices, arts & ... self-confidence. , Camp Directors Amber East-D’Anna and Christy Evans have combined backgrounds in ...
(Date:5/26/2016)... ... , ... The MIAMI Institute for Age Management and Intervention celebrates Global Wellness ... Dr. Adonis , Wellness Physician of the MIAMI Institute is certified by the ... Functional Medicine. , He also heads up FITTLab, the comprehensive medical testing lab located ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... 2016 Cirujanos holandeses han puesto ... los médicos a compartir sus mejores prácticas por el ... Profesionales médicos de Europa, África, Asia ... la aplicación, que combina la transmisión en vivo con ... Educación   "Imagine un médico de ...
(Date:5/24/2016)... Mass. , May 24, 2016  NxStage Medical, ... technology company focused on advancing renal care, today announced ... plans to participate in the following schedule of investor ... be made available at http://ir.nxstage.com/ . ... Jefferies Healthcare Conference NY, NY           Friday, June ...
(Date:5/24/2016)... HONG KONG , May 24, 2016 ... de COMBO ™ , la ... présentent des cathéters destinés à l,intervention portant ... artério-veineuse (FAV)   OrbusNeich, entreprise ... vasculaires permettant de changer la vie, a ...
Breaking Medicine Technology: