Navigation Links
Key Found to Kill Cystic Fibrosis Superbug

Researchers from the Schulich School of Medicine & Dentistry at The University of Western Ontario , working with a group from Edinburgh//, have discovered a way to kill the cystic fibrosis superbug , Burkholderia cenocepacia. These investigators, under the leadership of Dr. Miguel Valvano, Department of Microbiology and Immunology, have had their research published in the May issue of the Journal of Bacteriology, and highlighted in Nature Reviews/Microbiology.

B. cenocepacia is a multi-drug resistant microorganism that lives in damp or wet places and causes rot in plants such as onions. While it rarely causes infection in healthy people, it can be fatal for people with cystic fibrosis (CF), an inherited disease where the lungs become clogged with thick mucus, often leading to chronic respiratory infections.

The team of researchers has identified a weakness in the armour that protects the B. cenocepacia bacterium from the effects of antibiotics. They hypothesize that preventing the synthesis of a key sugar required for this armour, 4-amino-4-deoxy-L-arabinose (Ara4N), may lead to a susceptibility within the cell membrane to antibiotics.

"We are very excited with these findings, as they will let us come up with novel molecules to disrupt the making of Ara4N," says Valvano. "These molecules could then be tested as novel antibiotics." Valvano is a Professor and Chair of the Department of Microbiology and Immunology, a Canada Research Chair in Infectious Diseases and Microbial Pathogenesis, and leader of the Infectious Diseases Research Group at the Siebens-Drake Research Institute. He is available for interviews.

The research was funded through the Canadian Cystic Fibrosis Foundation and the Canadian Institutes of Health Research (CIHR). "We're delighted by this news," says Cathleen Morrison, CEO of the Canadian Cystic Fibrosis Foundation. "The possibility of a life-saving antibiotic to fight B. cenocepacia is tremendously encouraging to adults and children who have cystic fibrosis."

Dr. Bhagirath Singh, Scientific Director of the CIHR Institute of Infection and Immunity, says "This discovery provides new hope for the eradication of these bugs from cystic fibrosis patients and to improve their quality of life by developing new treatments."

Source-Eurekalert/B
'"/>




Related medicine news :

1. Fluoride Found Effective in Osteoporosis
2. Implantable Contact Lens Found Safe and Effective
3. Cancer hazard Found With Animal-Based Nutrients
4. Processed Meat, Diabetes connection Found
5. Night Time Aspirin Regimen Found to Reduce Blood Pressure
6. Hydrotherapy Found to be Effective for Patients with Osteoarthritis
7. Hydrotherapy Found to be Effective for Patients with Osteoarthritis
8. Preventive Therapies Found to be More Effective in Managing Migraines
9. Common Cold Found to Fight Cancer
10. Circumcision Found To Prevent HIV Spread
11. Drug Found To Reduce The Transmission Of Herpes
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/1/2017)... Calif. (PRWEB) , ... March 01, 2017 , ... Award-winning ... has completed 25 medical mission trips in underdeveloped nations, averaging more than one trip ... 2016. An article on the website features the details of his charitable ...
(Date:3/1/2017)... ... March 01, 2017 , ... NYC based Integrated practice Living Well ... to announce the addition of Orthopaedic Surgeon Dr. Donald E. Heitman. Dr. ... Cornell University with a Bachelor of Science degree in biology. He then obtained his ...
(Date:3/1/2017)... ... 01, 2017 , ... “There is Comfort for the Soul”: a loving account ... their all-too-brief time together, and the soul-healing comfort provided by God’s presence in the ... published author, Jerie A. Tau, a dog-loving medical professional whose work takes her to ...
(Date:3/1/2017)... ... ... Way: Key To One Flesh”: a collection of real marital scenarios and solutions for ... Cecilia Chiam, a writer who emigrated to the United States in 1978. , ... problems with the guidance and support of Holy Scripture. , “This is a ...
(Date:3/1/2017)... ... March 01, 2017 , ... Adherence Compliance, the ... Cannabis Compliance Program for Regulatory Agencies. The regulatory agency program is the first ... internal or outsourced compliance program options, as well as an app for inspections ...
Breaking Medicine News(10 mins):
(Date:3/1/2017)... Mar 01, 2017 ... Research and Markets has announced ... to 2017" report to their offering. The ... report provides understanding and access to partnering deals and agreements entered ... provides an analysis of partnering deals. The majority of deals are ...
(Date:3/1/2017)... Research and Markets has announced the addition of the ... to their offering. ... This analysis is one of the most accurate studies performed ... financial data derived from varied research sources to present unique and ... market during the next five years, including a deep dive analysis ...
(Date:3/1/2017)... , March 1, 2017  Numotion, the nation,s leading ... availability of Tek RMD ("robotic mobilization device") by Matia ... Tek RMD is a motorized standing movement device that ... manual wheelchair to complete everyday activities from a standing ... a Tek RMD unassisted. Numotion is the exclusive distributor ...
Breaking Medicine Technology: