Navigation Links
Jumping genes eliminate sections of DNA

A recent study reveals that jumping genes appear to be able to delete sections of DNA, an effect that could cause disease and have profound implications for the evolution of the human genome. It was known previously that components of DNA called Line 1 elements jumped around, inserted themselves in the middle of genes and had disruptive effects,// but this is the first time it has been shown they actually can delete significant portions of DNA, John Moran, an author of the study and assistant professor of human genetics and internal medicine at the University of Michigan Medical School, said in describing the results of the research.

These L1 elements technically are classified as transposons -- bits of DNA that can move around to different positions on the genome of a single cell -- could have implications for causing disease, but some of the deletions also may be beneficial, Moran told United Press International.

Haig Kazazian, chairman of the University of Pennsylvania's department of genetics and author of an accompanying review of transposons, said the study shows L1 elements "could have substantial effect on the evolution of the genome and how it's changing."

Although they have been linked to some diseases, "they're not a huge contributor" to causing disease, he told UPI. For example, "we don't think they are a frequent cause of cancer," he said. "The real significance of L1 elements is the evolution of the genome," he said, noting humans have 520,000 of them in our genome.

The research was done with a strain of human tumor cells so it is not yet known if the gene jumping occurs in normal, healthy cells, Moran explained. However, a connection is likely because it has been seen in mice cells and we now know it occurs in human tumor cells, he said. The jumping occurs primarily in sperm and egg cells and not in other cells of the body, he noted, which means any mutation effect they have is already present in our bodies at birth.

The L1 elements use a process called reverse transcription to move about and insert themselves into DNA sequences. The researchers found four of 37 jumping events resulted in deletions of genetic material. One of the deletions was nearly as large as an entire gene.

Although they once were labeled junk or useless DNA, these jumping elements have been known for some time to affect the genome profoundly. L1 elements, which account for about 17 percent of our genome, have been implicated in a type of hemophilia -- a condition in which the blood does not clot after a cut -- and several other diseases.

In addition, L1 elements also can carry junk DNA elements known as Alu, which account for another 10 percent of the genome. Alu elements may play a role in several diseases and are known to have played a major effect in modifying our DNA as we evolved. Altogether, L1 elements "may be responsible for creating about 27 percent of our DNA and perhaps more," Moran said. "So these have been significant players in evolution and shaping the human genome."


'"/>




Related medicine news :

1. Jumping The Queue Has Left Hospital Suspending Transplantation
2. Cirrhosis linked to genes
3. Altering genes through calories
4. Predictable genes
5. Endometriosis coalesced with genes
6. Birth weight may be influenced by genes
7. New breast cancer genes discovered
8. Altitude sickness connected to genes
9. Multiple organ disease cured by genes
10. Function of genes in heart failure
11. Discovering cholesterol-absorbing genes
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2017)... , ... June 23, 2017 , ... Everybody has their ... while others prefer to read it, and some people don't like it at all. ... Here's what they found: , Erotic literature can give readers a taste of their ...
(Date:6/23/2017)... ... June 23, 2017 , ... 21 Middle East and South Asia Leaders Selected ... from government, business and civil society in 11 countries across the Middle East and ... in a transformative exchange of knowledge and ideas with the leading minds in their ...
(Date:6/23/2017)... ... 23, 2017 , ... Ulster University, Magee Campus in Northern Ireland is hosting ... pm to present to graduate students exciting new and innovative hope research based on ... by The Health Improvement Service of the Western Health & Social Care Trust (WHSCT) ...
(Date:6/23/2017)... ... June 23, 2017 , ... Moore Insurance, ... area with access to asset protection and financial planning services, is teaming up ... improving the lives of children with cancer and other chronic diseases. , The ...
(Date:6/22/2017)... ... June 22, 2017 , ... ... from the American Heart Association (AHA) to launch a Rheumatic Heart Disease Center, ... prevention and diagnosis of rheumatic heart disease (RHD) in high-risk, financially disadvantaged countries ...
Breaking Medicine News(10 mins):
(Date:6/16/2017)... , June 16, 2017  Exactly 50 years ago ... off what later became known as the San Francisco "Summer ... ) is unveiling two radical innovations in strategic market research ... This announcement marks the beginning of Northern Light,s "Summer of ... ...
(Date:6/12/2017)... , June 12, 2017 Kineta, Inc., a biotechnology ... Kineta Vice President of R&D and Head of ... Pandemic Preparedness for the Northwest and Beyond meeting ... on June 14, 2017 from 8:30-10:30 AM PDT at the ... Dr. Bedard will be joined by other ...
(Date:6/8/2017)... MAITLAND, Fla. , June 8, 2017  Less ... ransomware attack that hit more than 200,000 companies, including hospital ... is being heralded as one of the largest online ... technology in the healthcare market, it is imperative that ... can protect their data from this — and many ...
Breaking Medicine Technology: