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Joint Center for Molecular Modeling Instituted by Burnham Institute for Medical Research & UC San Diego

t the National Institutes of Health, which funded the new project. "By developing and using new computational approaches, the group will improve our ability to accurately model the three-dimensional structures of proteins, which are invaluable to functional studies and rational drug design."

Adam Godzik, Ph.D., is Professor and Director of the Bioinformatics and Systems Biology Program at the Burnham Institute for Medical Research. Yuzhen Ye, Ph.D., and Piotr Cieplak, Ph.D., are Research Assistant Professor and Staff Scientist, respectively, at the Burnham. Pavel Pevzner, Ph.D., is the Ronald R. Taylor Professor of Computer Science in the Department of Computer Science and Engineering at UCSD's Jacobs School of Engineering.

According to Pevzner, predicting protein structures represents a rich source of new algorithmic challenges. "In recent years new mathematical tools have revolutionized the way we describe rearrangements of genomic elements and domain reshuffling in multi-domain proteins," said Pevzner. "We believe that they can also be used to recognize and describe the movements of micro-domains in protein structures, and that will be the focus of the Computer Science and Engineering department's participation in this collaboration with the Burnham Institute."

Source :Eureka Alert


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