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John Hopkins Develops An Online Tool To Help In Research Of Certain Rare Diseases

The research team from Johns Hopkins and made available on the World Wide Web - a database of all genes known to contribute to cilia operations in the body. //

The researchers had earlier identified flaws in the work of minute, hair-like structures on the surface of cells called cilia as such a common link. They had explained that the so called 'orphaned diseases' all have links associated with the tiny, hair-like cilia and implications for common disorders.

The researchers had explained that many people are bothered with rare illnesses of unknown cause, and finding a common link to such rare and less studied or 'orphaned' diseases, like Bardet-Biedl, Alstrom and Meckel-Gruber syndromes can significantly advance the search for causes and treatment.

'It was hard labour but worth it to help accelerate research and drive the development of potential drug targets and cures for these diseases,' says the project's leader, Nicholas Katsanis, Ph.D., an associate professor of molecular biology and genetics and ophthalmology at the McKusick-Nathans Institute of Genetic Medicine at Hopkins.

'But what's equally exciting is that the database should also advance the understanding of much more common diseases, because abnormal cilia are looking as if they have a role in these as well,' he adds.

The new Web-based resource will be described online Aug. 29 at Nature Genetics and will be freely available to all researchers.

'In recent years it's become clear that there is a broad spectrum of human disorders - including polycystic kidney disease and left-right axis defects, for example - that share similar clinical problems and cilia malfunctions,' says Katsanis.

Cilia are organelles whose main function was once thought confined to helping one-celled organisms propels themselves around. Although they had been observed in many tissues in humans and other mammals, some researchers considered them 'vestigia l', an evolutionary relic from our progenitors. But a small band of investigators, including Katsanis at Hopkins, have begun to assign function to cilia in numerous cell types in the human body and speculate that 'anything so highly conserved by evolution is likely critical for survival.'

Work by Katsanis' group as well as others in the field shows that more than 1,000 genes are known to play a role in cilia. Some genes contribute to their structure, others contribute to function and yet others only have been implicated in some sort of cilia-related role.

'There's a lot we still don't know about cilia, and much work needs to be done,' says Katsanis. 'But this new database consolidates a considerable volume of knowledge floating around out there, and we hope it will focus not only our research but others, as well to speed our way to better treating these patients.'

Bardet-Biedl, Alstrom and Meckel-Gruber patients share similar symptoms, including kidney problems, vision problems and cognitive dysfunction.

Although all are marked by aberrant cilia, the different symptoms associated with each syndrome affect individual patients differently. Many patients first go to the doctor because they experience vision problems, and they are treated for those vision problems. But the patients may be unaware that they are experiencing other problems - dubbed sub-clinical - such as slow kidney failure.

Studying the genes involved is expected to shed light on how cilia function. And a better understanding of normal cilia function, according to Katsanis, will lead to a better understanding of what goes wrong when cilia don't function. 'Having a good handle on genes may lead to future genetic tests that can help doctors better diagnose and treat these syndromes,' he says.

'Studying the genetics, heritability and molecular underpinnings of Bardet-Biedl syndrome uncovered the role of cilia in this and other syndromes ,' says Katsanis. 'The clinic informing the science got us where we are today. Now we have the tool to enable the science to go back and inform the clinic.'

Source: EurekAlert.
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