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Jefferson Researchers Want to Learn If Heart Defect 'at Heart' of Some Migraines

sed for other reasons," said Stephen Silberstein, M.D., director of the Jefferson Headache Center, the study's other primary investigator.

"We need to be able to prove that closure of a PFO by itself will actually diminish migraines," said Dr. Silberstein, Professor of Neurology, Jefferson.

In this study, participants will be randomly assigned to one of two groups. One group will undergo a minimally-invasive procedure to close their PFO. An interventional cardiologist will insert a catheter into the heart and release a device which will form a seal around the PFO to prevent the incorrect blood flow. Typically, the procedure lasts one to two hours under local anesthesia.

The other group will not have their PFO closed but will undergo a procedure that only mimics the closure and will continue medical therapy for their migraines. But none of the participants will know to which group they have been assigned to. However, all participants will receive the same post-operative care and will leave the hospital within 24 hours.

Source-Eurekalert/B
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