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Its Possible To Grow Bone To Replace The Damaged Bone

tape: The outside is tough and fibrous but the inside is covered with a layer of special pluripotent cells which, like marrow cells, are capable of transforming into the different types of skeletal tissue. So Shastri and his collaborators decided to create the bioreactor space just under this outer layer.

They created the space by making a tiny hole in the periosteum and injecting saline water underneath. This loosened the layer from the underlying bone and inflated it slightly. When they had created a cavity the size and shape that they wanted, next the researchers removed the water and replaced it with a gel that is commercially available and approved by the FDA for delivery of cells within the human body. They chose the material because it contained calcium, a known trigger for bone growth. Their major concern was that the bioreactor would fill with scar tissue instead of bone, but that didn?t happen. Instead, it filled with bone that is indistinguishable from the original bone.

The scientists intend to proceed with the large animal studies and clinical trials necessary to determine if the procedure will work in humans and, if it does, to get it approved for human treatment. At the same time, they hope to test the approach with the liver and pancreas, which have outer layers similar to the periosteum.

Source: Newswise

Medindia on bone disease: Further information

Bone disease: Bone disease may be of various types, inherited or acquired. Some common bone diseases are osteoporosis, Paget?s bone disease, and myeloma bone disease. For more information read:


http://www.medindia.net/patients/
patientinfo/osteoporosis.asp

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