Navigation Links
It's Never too Late to Get It Back! Aging Interrupted

Much research has shown that reduced calorie intake can increase health and longevity. //Professor Stephen Spindler (University of California) and his collaborators* have discovered that reducing calorie intake later in life can still induce many of the health and longevity benefits of life-long calorie reduction. Importantly, this also includes anti-cancer effects. They are using this knowledge to establish a novel screening technique to find drugs which mimic this longevity effect. “Right now, there are no authentic “anti-ageing drugs” capable of extending the lifespan of healthy people. The technique we have developed allows us to screen a relatively large number of drugs in months rather than years. The hope is that these drugs will be able to extend the lifespan of healthy animals, and possibly, after further testing, healthy humans”, says Professor Spindler who will present his results at the Society for Experimental Biology’s Main Meeting in Glasgow on Monday 2nd April.

Previous research has show that mice can live up to 40% longer if they simply consume fewer calories, but a highly nutritious diet. Because people are not very good at dieting, Dr. Spindler and his colleagues would like to identify drugs which can produce the same beneficial health and longevity effects without the low calorie diet. The problem is to find a way to rapidly identify these drugs. Professor Spindler and his colleagues are examining the gene expression patterns which are induced by low calorie diets, and looking for drugs which mimic these changes. They are searching for drugs which will have these beneficial effects and slow ageing, even when they are given late in life. One drug, normally used to treat diabetic patients, seems to produce many of the beneficial effects of a low calorie diet. However, it is important to be sure that healthy people will benefit from the drug. A very low level of toxicity could interfere with the beneficial effects of such a drug, if it i s taken for a lifetime.

Physiological changes associated with ageing include cell damage and the emergence of cancer cells. The most important effects of low calorie diets and longevity therapeutics given late in life may not be to prevent this damage, but instead to stimulate the body to eliminate damaged cells that may become cancerous, and to stimulate repair in damaged cells like neurons and heart cells. Low calorie diets drive the body to replace and repair damaged cells. This process usually slows down as we age, but low calorie diets make the body re-synthesise and turn over more cells – a situation associated with youth and good health. Dr. Spindler and his colleagues used their screening method to search for drugs which cause pre-cancerous and cancerous cells to commit suicide and to replace those cells with new, healthy cells. It is thought that the body does this because it normally kills some cells like damaged and rogue cancer cells to provide energy when it is starving. Then it replaces these cells when a meal is eaten.

It seems it is the total number of calories which are consumed, rather than the type of food which is the key to the effects of low calorie diets on the ageing process. However, it is known that vegetarians and fish eaters live longer than red meat eaters, and that, generally, the more fruit and vegetables in the diet, the better your health and longer your lifespan.


Related medicine news :

1. Its Never Too Late to Stop Smoking,Study Finds
2. ‘Never Say Die’ Spirit of Visually Challenged - Makes Him a Role Modl
3. Never undermine the importance of calcium and Vitamin D
4. Never Forget Brushing And Flossing
5. A Compensation Deal is Better Late than Never!
6. Never-Betrayed Men Less Likely to Indulge in Child Sex Abuse
7. Plastic Sling Has Proved Successful In Improving Aging Of The Neck
8. Gene That Might Be Responsible For Aging
9. Genetic Expressions Can Influence The Process Of Aging
10. Premature Aging Can Be Managed With Anti-Cancer Drugs In Future
11. Ward Off Aging With A Low-Calorie Nutritional Diet
Post Your Comments:

(Date:12/1/2015)... ... 01, 2015 , ... Tympani Inc., announced today that it ... Cisco. This designation recognizes Tympani as having fulfilled the training requirements and program ... the high-end enterprise contact center marketplace. , Ed Kapelinski, President of Tympani stated, ...
(Date:11/30/2015)... ... December 01, 2015 , ... The National Association of ... into its VIP Woman of the Year Circle. She is recognized with this ... exclusively for professional women, boasting 850,000 members and over 200 operating Local Chapters. ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... stressful. At the VA Maryland Health Care System, the Caregiver Support Program ... “Caregivers have a difficult job. Seventy-four percent report that their role as ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... dermatology, is proud to announce that its ThermiRFR temperature controlled radiofrequency platform has ... an innovative multi-application radiofrequency platform which uses temperature as a clinical endpoint. ...
(Date:11/30/2015)... , ... November 30, 2015 , ... ... fun atmosphere for Halloween festivities, the Word of Life Christian Church of Flint, ... game, and featuring a giant 1.25 ton pile of candy dubbed “Candy Mountain”. ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... Fla. , Nov. 30, 2015   The ... (the Institute) announced today that it has finalized a ... start-up company with technology developed at Florida State University. ... research, and bridges early funding gaps for companies spinning ... research institutions. --> ...
(Date:11/30/2015)... , November 30, 2015 /PRNewswire/ ... --> adds a ... for 2010 - 2015 with comprehensive ... a range of deal types, such ... strategic alliances. ...
(Date:11/30/2015)... -- --> --> According ... Product (Soft Tissue, All Tissue, Dental Welding Lasers), Application (Conservative ... - Global Forecast to 2020", published by MarketsandMarkets, is expected ... of 5.2% during the forecast period from 2015 to 2020. ... Figures spread through 167 P ages and in-depth TOC ...
Breaking Medicine Technology: