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Is There Any Clinical Benefit to Staying on a Failing Regimen?

latively higher CD4 cell count nadirs did not lose drug options to the same degree as did others in the study (0.34 drugs less per 100 cells/mm3). Additionally, patients on 3TC (lamivudine) showed a slower accumulation of nucleoside mutations and thymidine analogue mutations (TAMs).

According to the authors, this study suggests that each individual’s history of immune suppression can affect the accumulation of drug resistance mutations.



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