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Internet Based Tool, BGEM To Help In Study Of Brain Development

tific databases such as LocusLink, PubMed, Unigene and Gene Ontology Consortium are providing information for the website.

The Gene Expression Nervous System Atlas (GENSAT), supported by National Institute of Neurological Diseases and Stroke (NINDS) in turn uses the images. The institution hopes to document the expression of all these genes.

The extensive support from the Bioinformatics Department at St. Jude’s has played a crucial role in the BGEM’s success. Bioinformatics refers to the use of IT gadgets such as computers, software and other technologies to collect, organize, and use huge amounts of biological information.

The software enables online search of scientific databases for latest information on genes that influence gene development. 'Our ability to link images of gene expression patterns to information on those genes in other databases increases the value of each new gene discovery,' said Perdeep Mehta, group leader in bioinformatics at St. Jude's Hartwell Center for Bioinformatics and Biotechnology.

'A researcher who discovers a previously unrecognized gene that is expressed during brain development can rapidly determine how it fits into the overall scheme of brain development. The BGEM helps researchers skip over much of the drudgery of digging up information from the literature or from other databases,' commented Dr. Craig Brumwell, the GENSAT manager in St. Jude Developmental Neurobiology.


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