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International Collaboration Takes Aim at Rabies

The Massachusetts Biologic Laboratories (MBL) of the University of Massachusetts Medical School (UMMS) and the Serum Institute of India today announce //the formation of an historic collaboration to bring to the world a new, more cost-effective approach for preventing rabies in people.

The institutions will collaborate to test and manufacture a new monoclonal antibody (MAB) created by scientists at the MBL, in conjunction with the U.S. Centers for Disease Control and Prevention (CDC), which can neutralize multiple variants of the rabies virus. The MBL and Serum Institute plan to launch a Phase 1 clinical trial in India in 2007 to assess the safety and tolerability of the new MAB in people, with hopes of having the new, lower-cost treatment available within two years for people exposed to rabies. The treatment would then be made broadly available in India shortly thereafter.

“Rabies is a major global public health problem, so we are very pleased to be partnering with Serum Institute to bring this new approach to the millions of people who need it each year,” said Donna Ambrosino, MD, director of the MBL and a professor of pediatrics at the Medical School. “The institute’s top level scientific resources, its commitment to public health, and its global reach, make it the best partner for us in this important initiative.”

Based in Pune, India, the Serum Institute is the world’s largest manufacturer of vaccines. The Institute’s specific mission is to bring cost-effective vaccines and biologics to the developing world. Today, half of all children inoculated in the world receive vaccines from the Serum Institute. Cyrus S. Poonawalla, PhD, chairman of the Serum Institute, was recently awarded the prestigious Sabin Vaccine Institute Award, in recognition of his institute’s efforts over the past 35 years to improve and protect people’s health, particularly children. "The underprivileged should have an equal opportunity to utilize modern scie
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