Navigation Links
Insufficent Anti-inflammatoy Proteins Leads to Chronic Pain

One of the most common medical condition, chronic widespread pain is often difficult to treat as well as often associated with fatigue, depression and poor sleep.//

A link between fibromyalgia(FM)and cytokines was suspected following cancer patients deveolping FM like symptoms after treatment with cytokine interleukin -2. Since then, other studies have shown contradictory results. A new study published in the August 2006 issue of Arthritis & Rheumatism (http://www.interscience.wiley.com/journal/arthritis) examined cytokine profiles in patients with chronic widespread pain and found that they had significantly lower levels of the anti-inflammatory cytokines IL-4 and IL-10.

Led by Nurcan ü?eyler of Julius-Maximilians University in Wurzburg, Germany, researchers analyzed cytokines in 40 patients with chronic widespread pain (26 of whom had FM), 40 controls and an additional group of 15 patients. The 40 pain patients had received intravenous immunoglobulin (IVIG) as a novel treatment for pain that was not responsive to standard therapy, while the additional 15 patients did not receive this treatment. Blood samples were analyzed for both pro-inflammatory and anti-inflammatory cytokines. In addition, patients were asked to rate their pain, fatigue, mood, cognitive function and sleep quality on a scale of 1 to 10.

Patients in the pain group did not differ in the expression of the pro-inflammatory cytokines IL-2, IL-8 and TNFα, but did have significantly lower levels of the anti-inflammatory cytokines IL-4 and IL-10 compared with the healthy control group. The 15 patients in the additional group showed similar findings, although the difference in IL-10 between this group and the controls was not statistically significant.

The authors point out that there may be several factors involved in the cause of low cytokine levels and how they might be linked to pain. Previous studies have shown that IL-10, administered as a protein or via gene transfer, reduces sensitivity to pain. Similarly, IL-4 has been shown to dull the pain response. "Signals arising through physiologic stimulation of the opioid receptor system may be reduced in patients with low IL-4 levels with subsequent increase in pain perception and the common relative opioid resistance seen in patients with chronic widespread pain," the authors note. In addition, genetic variations in different cytokine genes are associated with distinct diseases, such as the association between IL-4 gene variations and asthma, Crohn's disease, and chronic polyarthritis. "The low levels of IL-4 and IL-10 we observed in the patients with chronic widespread pain might therefore also be caused by genetic alterations either in the cytokine genes themselves or in regulatory elements, although other factors may be involved," the authors state.

The authors acknowledge that this study on 6 key cytokines does not exclude the possibility that other cytokines may play a role in chronic widespread pain. While they acknowledge that low levels of anti-inflammatory cytokines may be a consequence of chronic widespread pain and its treatment, they favor the hypothesis that these proteins actually play a role in the pathophysiology of chronic widespread pain. "Once confirmed and validated in further studies," they conclude, "cytokine expression patterns may eventually help in supporting the diagnosis of chronic widespread pain and in guiding the appropriate treatment approach."

Source: Eurekaler
'"/>




Related medicine news :

1. Protective Clothing of Health Workers Insufficent Against Contamination
2. Levels Of Blood Proteins May Help Heart Disease Care
3. Cholesterol can be lowered using combination of Soy Proteins and Sterols
4. Neurological Disorders Overcome By Proteins
5. Cancer Causing Proteins Trigger Abnormal Biochemical Reactions In Cells
6. NR2B Proteins Lead To Chronic Pain
7. Methyl-DNA binding Proteins To Fight Cancer
8. Ape Humans? Alterations in Proteins Affects Genes.
9. Researchers Discover Two Proteins Involved In Cellular Destruction Of HIV Virus
10. Blood Clotting Disorders Linked To Three Proteins
11. Transport of Proteins Unravels the Mystery behind Neurodegenerative Diseases
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/17/2017)... ... January 17, 2017 , ... ... and eliminate cyber threats in real-time, today announced a strategic partnership with ... Selangor, Malaysia. Joining other Seceon partners, TechLab Security has become a strategic partner ...
(Date:1/17/2017)... ... 2017 , ... Today, FloSports , a global leader in live digital ... part of a long-term extension of their media partnership. The partnership, which began in ... the sport’s premier events exclusively on FloWrestling.com as well as usage of the FloArena ...
(Date:1/16/2017)... ... 2017 , ... Gym Source, America’s leading retailer of premium residential and commercial ... Jersey. , “We are elated to be opening this new showroom,” explains Tom Richard, ... give clients a seamless and motivating shopping experience.” , Every fitness journey is unique, ...
(Date:1/16/2017)... (PRWEB) , ... January 16, 2017 , ... ... today announced the addition of Victor Giamos, MD to their medical staff, ... and Managing Partner at North Shore Eye Care, a division of SightMD. Dr. ...
(Date:1/16/2017)... ... January 16, 2017 , ... Date aired: January 9, 2017 ... Sharon Kleyne, America’s leading water educator, researcher and advocate welcomed health activist, author, ... Sharon Kleyne Hour Power of Water, Global Climate Change and Your Health on ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... Interpace Diagnostics Group, Inc., (NASDAQ: IDXG ... tests and pathology services for evaluating risks of cancer, ... January 13, 2017 from the NASDAQ Listing Qualifications notifying ... requirement of the NASDAQ Stock Market to maintain a ... The letter noted that for the last 10 ...
(Date:1/17/2017)... Jan. 17, 2017 Tempus, a technology ... and University Hospitals Seidman Cancer Center have joined ... genomic data, advanced molecular analysis and clinical decision ... and healthcare providers. As part ... and transcriptomic sequencing and analysis for ovarian and ...
(Date:1/17/2017)... , Jan. 17, 2017  CSSi, the global ... the clinical research industry, will exhibit at the 8 ... Executives (SCOPE 2017), taking place from Tuesday, January 24 ... Miami in Miami, FL. ... proprietary technology platform, SmartStudy™ EMR, which provides a revolutionary ...
Breaking Medicine Technology: