Navigation Links
Insufficent Anti-inflammatoy Proteins Leads to Chronic Pain

One of the most common medical condition, chronic widespread pain is often difficult to treat as well as often associated with fatigue, depression and poor sleep.//

A link between fibromyalgia(FM)and cytokines was suspected following cancer patients deveolping FM like symptoms after treatment with cytokine interleukin -2. Since then, other studies have shown contradictory results. A new study published in the August 2006 issue of Arthritis & Rheumatism (http://www.interscience.wiley.com/journal/arthritis) examined cytokine profiles in patients with chronic widespread pain and found that they had significantly lower levels of the anti-inflammatory cytokines IL-4 and IL-10.

Led by Nurcan ü?eyler of Julius-Maximilians University in Wurzburg, Germany, researchers analyzed cytokines in 40 patients with chronic widespread pain (26 of whom had FM), 40 controls and an additional group of 15 patients. The 40 pain patients had received intravenous immunoglobulin (IVIG) as a novel treatment for pain that was not responsive to standard therapy, while the additional 15 patients did not receive this treatment. Blood samples were analyzed for both pro-inflammatory and anti-inflammatory cytokines. In addition, patients were asked to rate their pain, fatigue, mood, cognitive function and sleep quality on a scale of 1 to 10.

Patients in the pain group did not differ in the expression of the pro-inflammatory cytokines IL-2, IL-8 and TNFα, but did have significantly lower levels of the anti-inflammatory cytokines IL-4 and IL-10 compared with the healthy control group. The 15 patients in the additional group showed similar findings, although the difference in IL-10 between this group and the controls was not statistically significant.

The authors point out that there may be several factors involved in the cause of low cytokine levels and how they might be linked to pain. Previous studies have shown that IL-10, administered as a protein or via gene transfer, reduces sensitivity to pain. Similarly, IL-4 has been shown to dull the pain response. "Signals arising through physiologic stimulation of the opioid receptor system may be reduced in patients with low IL-4 levels with subsequent increase in pain perception and the common relative opioid resistance seen in patients with chronic widespread pain," the authors note. In addition, genetic variations in different cytokine genes are associated with distinct diseases, such as the association between IL-4 gene variations and asthma, Crohn's disease, and chronic polyarthritis. "The low levels of IL-4 and IL-10 we observed in the patients with chronic widespread pain might therefore also be caused by genetic alterations either in the cytokine genes themselves or in regulatory elements, although other factors may be involved," the authors state.

The authors acknowledge that this study on 6 key cytokines does not exclude the possibility that other cytokines may play a role in chronic widespread pain. While they acknowledge that low levels of anti-inflammatory cytokines may be a consequence of chronic widespread pain and its treatment, they favor the hypothesis that these proteins actually play a role in the pathophysiology of chronic widespread pain. "Once confirmed and validated in further studies," they conclude, "cytokine expression patterns may eventually help in supporting the diagnosis of chronic widespread pain and in guiding the appropriate treatment approach."

Source: Eurekaler
'"/>




Related medicine news :

1. Protective Clothing of Health Workers Insufficent Against Contamination
2. Levels Of Blood Proteins May Help Heart Disease Care
3. Cholesterol can be lowered using combination of Soy Proteins and Sterols
4. Neurological Disorders Overcome By Proteins
5. Cancer Causing Proteins Trigger Abnormal Biochemical Reactions In Cells
6. NR2B Proteins Lead To Chronic Pain
7. Methyl-DNA binding Proteins To Fight Cancer
8. Ape Humans? Alterations in Proteins Affects Genes.
9. Researchers Discover Two Proteins Involved In Cellular Destruction Of HIV Virus
10. Blood Clotting Disorders Linked To Three Proteins
11. Transport of Proteins Unravels the Mystery behind Neurodegenerative Diseases
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... As health professionals work to improve ... engagement.” The patient is doing more than filling out a survey; in many cases ... an increasing emphasis in health care and research on the importance of active engagement ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... ‘17, and Jennifer Huggins, PharmD ’17, along with clinical associate professor Janice ... of cardiovascular diseases during the 15th Annual Women’s Health Conference. The SIU ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for professional ... action towards gender equality at their inaugural Summit in New York City in June. ... a social audience of over 3 million. To watch the Mobilize Women video, ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to the ... save lost souls in the Philippines. “The Journey: From the Mountains to the Mission ... of the Bible. She has taught all ages and currently teaches a class of ...
(Date:10/12/2017)... ... 12, 2017 , ... The company has developed a suite ... regulatory authorities worldwide. From Children’s to Adults 50+, every formula has been developed ... , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, Non-Dairy*, ...
Breaking Medicine News(10 mins):
(Date:9/13/2017)... 2017   OrthoAtlanta has been named the official ... Committee (AFHC) for the 2018 College Football Playoff (CFP) National ... Mercedes-Benz Stadium in Atlanta, Georgia . OrthoAtlanta ... In" campaign, participating in many activities leading up to, and ... ...
(Date:9/12/2017)... 12, 2017  Consumer reviews on the independent review site ... number one company for hearing aids, ranking it higher than ... ... by Consumers For Hearing Aids ... is an online store that provides high performance, state-of-the-art, German-engineered hearing ...
(Date:9/9/2017)... , Sept. 8, 2017 ... Mobile MRI Unit coming to Washington DC ... When: Tuesday, September 12 th – Monday, September ... Washington, D.C. offering free MRI brain scans to the public.Where:  ... will be parked at 501 K Street NW, Washington, D.C.What:BTF brings its ...
Breaking Medicine Technology: