Navigation Links
Insilico Studies on Chlorine Eating Bacteria

Certain bacteria that break down pollutants do their job and then to make them more effective in cleaning up toxic wastes. Research was conducted on those bacteria by cornell researchers using computer models.

Bacteria called Dehalococcoides ethenogenes, discovered in Ithaca sewage sludge in 1997 by James Gossett, Cornell professor of civil and environmental engineering, and isolated and studied by Stephen Zinder, Cornell professor of microbiology, are now in wide use to detoxify such carcinogenic chemicals as perchloroethylene (PCE) and trichloroethylene (TCE). They do this by removing chlorine atoms from molecules and leaving less-toxic compounds behind.

But D. ethenogenes strains work well at some sites and not so well at others, and nobody knows for sure why. In fact, very little is understood about how these organisms live and breathe.

Normal laboratory procedures haven't provided enough answers, because the bacteria are hard to grow in a petri dish, said Ruth Richardson, Cornell assistant professor of civil and environmental engineering, who is following up on Gossett's and Zinder's work, in continued collaboration with them.

She is partnering with Gene Network Sciences (GNS), a firm specializing in computer simulation of biochemical processes, to create computer models of the inner workings of the bacterium. The project is funded by a three-year, $381,000 grant from the Department of Defense, which has some 6,000 toxic-dump sites of its own to clean up.

Richardson explained that in the field "the bacteria sometimes start and then stop. We might improve conditions for the organisms." For example, she said, it has been found that Dehalococcoides needs vitamin B-12, so the vitamin is added to cultures that are injected into cleanup sites.

The bacterium also grows better in a mixed community with other kinds of bacteria. "There are some factors it needs from other organisms, and we d on't know yet what they are," she said.

Her laboratory will test the D. ethenogenes strains under a variety of different conditions, such as exposing them to different chlorinated compounds one at a time, varying the environment or the nutrients supplied, and then observing which genes are expressed and what proteins are manufactured.

The data will go to GNS, which will try to build computer models of how the bacteria's proteins work together under each condition and whether the pathway for each condition is the same for PCE and TCE, and if not, what steps they have in common.

It will be an "iterative process," Richardson said. If a model shows that changing a particular condition produces a particular result, the lab will try it out and see if the result matches the model. Eventually, Richardson said, some commonalities should appear.

"There will be a suite of models, and we can highlight features that are common across several models," she said. "As we develop the model, we can begin to look at the genomes of other strains of Dehalococcoides. If genes that are important in our strain are found in others, then we can do the same experiments with the others. Finding which genes are at work with which pollutants might lead to understanding how to remediate other kinds of pollutants, such as PCBs, dioxins, chlorobenzenes or chlorophenols.

Richardson, who grew up in the Hudson River Valley, notes that such pollutants are common in the river's harbors. "There are still thousands of sites around the country that need to be cleaned up," she said. "Ithaca has three or four, and that's not atypical."


'"/>




Related medicine news :

1. Studies On Hearing Loss Discovers New Causes
2. Broccoli Found to Block Cancer Progression In Both Animal and Human Studies
3. Cure For Autism Could Be Established Through Hamster Studies
4. Despite More Studies Researchers Are Still Confound With ADHD
5. Studies Show Brain becomes Less Specialized With Age
6. ISB To Establish Research Chair On Real Estate And Urban Studies
7. Studies Show Combination Drugs As A Poor Substitute For Anti-Coagulants In Stroke
8. Further Studies Needed To Completely Understand About Ventricular Fibrillation
9. Studies Report Mammograms Unsafe
10. Six Indians Win Australian Studies Fellowships
11. Circumcision Studies to Continue Says Health Panel
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/16/2017)... , ... August 16, 2017 , ... “God Will Break Every Chain”: an inspirational story ... Chain” is the creation of published author, Evangelist Joann Shivers, a writer and a woman ... was on her life at an early age. She was born and raised in ...
(Date:8/15/2017)... (PRWEB) , ... August 15, 2017 , ... ... of disease. It’s reaching out to a patient who feels isolated. It’s developing ... amid madness. , WesternU President Daniel R. Wilson, MD, PhD, invited three renowned ...
(Date:8/15/2017)... ... August 15, 2017 , ... The city of Los Angeles is a west coast style ... Style”. LA’s Top Style List, a website that spotlights fashion news from Los Angeles and ... wardrobe all year long. , According to the senior editor of latsl.com , “For ...
(Date:8/15/2017)... (PRWEB) , ... August 15, 2017 , ... ... case of a woman who fell into a coma and died after receiving ... surgeon. The procedure was performed in the alleged perpetrator’s apartment after the victim ...
(Date:8/15/2017)... City, Florida (PRWEB) , ... August 15, 2017 ... ... of cold therapy products, announced today the introduction of the innovative new 10x10 ... created for post-operative patients. The plush design enhances comfort and enables the patient ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... and Gulf Coast Regional Blood Center to host a blood ... Law family has had 3 members that needed blood products ... is partnering with Gulf Coast Regional Blood Center of ... supplies are running low. Gulf Coast Regional Blood Center,s inventory is ... is why the blood center reached out to Mostyn Law ...
(Date:8/15/2017)... 15, 2017 Diplomat Pharmacy, Inc. (NYSE: DPLO), ... Michigan residents. Naloxone is available ... retail pharmacy, G-3320 Beecher Road. ... and Drug Administration, is intended to block or reverse ... and loss of consciousness. The medication is often carried ...
(Date:8/15/2017)... N.C. , Aug. 15, 2017  Axium Pharmaceuticals Inc., the creator ... rumored to be in the beginning stages of an IPO. ... on epilepsy medications with the average cost of a prescription epilepsy drug ... ... Another staggering figure is the fact ...
Breaking Medicine Technology: