Navigation Links
Insights into Osteosarcoma in Cats and Dogs may Improve Palliative Care

Researchers at the University of Illinois have found that a molecular pathway known to have a role in the progression of bone cancer in humans is also critical to the pathology// of skeletal tumors in dogs and cats. Their work could lead to advances in the palliative care of companion animals afflicted with osteosarcoma.

The research team, which included U. of I. pathobiology professor Anne Barger, examined the homeostatic role of an enzyme, receptor activator of nuclear factor kappa-B (known as RANK), and two key modulators of its activity: RANK ligand (RANK-L) and osteoprotegrin (OPG). RANK is one of a family of receptors that regulates bone and immune homeostasis. In health, RANK, RANK-L and OPG together keep the continual process of bone growth and resorption in balance.

Bone tumors presumably derail this homeostatic process, however, by upregulating RANK-L expression. RANK-L binds to RANK, stimulating the production and activation of osteoclasts (bone cells that increase the breakdown of bone tissue).

OPG counter-regulates RANK-L by blocking its ability to bind to RANK.

Eventual therapeutic interventions may make use of OPG or other RANK-L inhibitors to slow the process of bone destruction in skeletal tumors in cats and dogs, Barger said. Although not a cure, this could reduce the pain and other complications associated with bone cancer. Such therapies have proven effective at reducing pathologic bone loss in human bone cancer patients.

The researchers are the first to verify that the expression of this protein, which worsens the effects of bone cancer in humans, also occurs in cats and dogs with skeletal tumors. Their study appears in the January-February issue of the Journal of Veterinary Internal Medicine.

“Osteosarcoma is much more common in veterinary medicine than in human medicine,” Barger said. “And in dogs it is fairly common.”

Other studies have reported a tenfold greater incidence of bone cancer in dogs than in humans.

“Owners often make decisions to euthanize based on pain,” Barger said. “If we can lessen the pain associated with the tumor we can improve the quality of life and the lifespan.”

Source-Bio-Bio TechnologyBR>SRM

Related medicine news :

1. Study Offers Insights Into Treatment Of Rheumatoid Arthritis
2. Reindeer Provide Valuable Insights Into Sleep Disorders
3. Insights Into Lead Pollution
4. Effect of Osteosarcoma predicted by scans
5. Hypertensive Drug Improves Sexual Dysfunction in Hypertensive Men
6. Steps To Improve Quality Of Plant-Based Drugs
7. Almonds Improve Cholesterol
8. How to Improve Life Expectancy
9. Sage Improves Memory
10. Protein said to Improve Muscle Loss
11. Ultrasound Screening Could Improve The Outcome Of Critically ill Patients
Post Your Comments:

(Date:10/13/2015)... ... October 13, 2015 , ... T-System and ... more than 59,000 emergency department visits per year, today announced the successful and ... help improve clinical, operational and financial outcomes. , In less than ...
(Date:10/13/2015)... ... , ... Tempe Dental Care, a leading Tempe dentists’ office, celebrates offering gentle, ... for more than 5 years. A leading cause of emergency room visits, school ... is not timely. , Sedation dentistry provides an anxiety-free dental experience ...
(Date:10/13/2015)... ... ... World Patent Marketing , a vertically integrated manufacturer and engineer of ... in clearing snow away from the streets and driveways. , "The Snowplowing Services industry ... Scott Cooper, CEO and Creative Director of World Patent Marketing and Desa Industries ...
(Date:10/13/2015)... ... October 13, 2015 , ... According to an ESPN ... orbital fracture when a teammate accidentally elbowed him in the left eye during the ... injury is just one of a series of setbacks, including a knee injury that ...
(Date:10/13/2015)... Irving, TX (PRWEB) , ... October 13, 2015 ... ... has tapped Dr. Bill Saye as the newest professional to introduce the latest ... Saye is highly recognized as a leading professional in Obstetrics and Gynecology and ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... 13, 2015  Measurement in accountable care programs ... financial incentives, but gaps in measurement can result ... health systems. A new, peer-reviewed study published ... explores measurement gaps for high-priority conditions ... --> --> "These ...
(Date:10/13/2015)... 2015  Nanomedical Diagnostics, a biotech company developing ... diagnostics, announces the completion of a Series A ... Ventures. --> ... monitoring and diagnostic platforms that empower individuals to ... will enable the company to commercially release AGILE ...
(Date:10/13/2015)... , Oct. 13 2015 ... the addition of the "US & ... 16 Countries (2010-2021)" report to their ... announced the addition of the "US ... - 16 Countries (2010-2021)" report to ...
Breaking Medicine Technology: