Navigation Links
Insights into Osteosarcoma in Cats and Dogs may Improve Palliative Care

Researchers at the University of Illinois have found that a molecular pathway known to have a role in the progression of bone cancer in humans is also critical to the pathology// of skeletal tumors in dogs and cats. Their work could lead to advances in the palliative care of companion animals afflicted with osteosarcoma.

The research team, which included U. of I. pathobiology professor Anne Barger, examined the homeostatic role of an enzyme, receptor activator of nuclear factor kappa-B (known as RANK), and two key modulators of its activity: RANK ligand (RANK-L) and osteoprotegrin (OPG). RANK is one of a family of receptors that regulates bone and immune homeostasis. In health, RANK, RANK-L and OPG together keep the continual process of bone growth and resorption in balance.

Bone tumors presumably derail this homeostatic process, however, by upregulating RANK-L expression. RANK-L binds to RANK, stimulating the production and activation of osteoclasts (bone cells that increase the breakdown of bone tissue).

OPG counter-regulates RANK-L by blocking its ability to bind to RANK.

Eventual therapeutic interventions may make use of OPG or other RANK-L inhibitors to slow the process of bone destruction in skeletal tumors in cats and dogs, Barger said. Although not a cure, this could reduce the pain and other complications associated with bone cancer. Such therapies have proven effective at reducing pathologic bone loss in human bone cancer patients.

The researchers are the first to verify that the expression of this protein, which worsens the effects of bone cancer in humans, also occurs in cats and dogs with skeletal tumors. Their study appears in the January-February issue of the Journal of Veterinary Internal Medicine.

“Osteosarcoma is much more common in veterinary medicine than in human medicine,” Barger said. “And in dogs it is fairly common.”

Other studies have reported a tenfold greater incidence of bone cancer in dogs than in humans.

“Owners often make decisions to euthanize based on pain,” Barger said. “If we can lessen the pain associated with the tumor we can improve the quality of life and the lifespan.”

Source-Bio-Bio TechnologyBR>SRM
'"/>




Related medicine news :

1. Study Offers Insights Into Treatment Of Rheumatoid Arthritis
2. Reindeer Provide Valuable Insights Into Sleep Disorders
3. Insights Into Lead Pollution
4. Effect of Osteosarcoma predicted by scans
5. Hypertensive Drug Improves Sexual Dysfunction in Hypertensive Men
6. Steps To Improve Quality Of Plant-Based Drugs
7. Almonds Improve Cholesterol
8. How to Improve Life Expectancy
9. Sage Improves Memory
10. Protein said to Improve Muscle Loss
11. Ultrasound Screening Could Improve The Outcome Of Critically ill Patients
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2018)... ... August 15, 2018 , ... Trumpet Behavioral Health ... associate editor of Behavior Analysis in Practice, one of the leading journals in ... standards and research officer for Trumpet, leading the company’s research clinical standards and ...
(Date:8/14/2018)... ... August 14, 2018 , ... ... (DSO) with nearly 400 affiliated offices across 16 states, is pleased to announce ... Diego, California. , Smile Brands will provide full-service administrative support to the practice, ...
(Date:8/11/2018)... ... August 10, 2018 , ... Johns Hopkins All Children’s Hospital ... the region by utilizing a population health perspective on care. At its core, this ... are being treated at the right facility or setting at the right cost. Mark ...
(Date:8/9/2018)... ... August 09, 2018 , ... Balboa Horizons, an industry ... process that substance abuse providers must pass in order to advertise on Google. ... people to help.” , Helping people is what Balboa Horizons is all ...
(Date:8/7/2018)... ... August 07, 2018 , ... Sussex Vision Center, a multi-site optometry practice ... Sussex, OD, founded the practice in Coldwater, and over the last three decades has ... to offer comprehensive eye health services for patients of all ages. , “I ...
Breaking Medicine News(10 mins):
(Date:8/15/2018)... ... August 15, 2018 , ... ... lineup of casters. The newly designed Diamond Series features a caster specifically ... Manufactured with an antimicrobial compound injected into a thermoplastic resin during molding, Diamond ...
(Date:8/11/2018)... ... , ... US Capital Global has been retained by Carepoynt as ... is an emerging leader in the digital health field. The company is dedicated to ... ecosystem. , Headquartered in San Francisco, US Capital Global is a full-service private financial ...
(Date:8/9/2018)... ... August 09, 2018 , ... Autism is a developmental disorder affecting ... widespread autism is, (approximately 1 in 68 people have the disorder), chances are you ... to help teach a child with autism methods of communication and tactics to interact ...
Breaking Medicine Technology: