Navigation Links
Insights into Osteosarcoma in Cats and Dogs may Improve Palliative Care

Researchers at the University of Illinois have found that a molecular pathway known to have a role in the progression of bone cancer in humans is also critical to the pathology// of skeletal tumors in dogs and cats. Their work could lead to advances in the palliative care of companion animals afflicted with osteosarcoma.

The research team, which included U. of I. pathobiology professor Anne Barger, examined the homeostatic role of an enzyme, receptor activator of nuclear factor kappa-B (known as RANK), and two key modulators of its activity: RANK ligand (RANK-L) and osteoprotegrin (OPG). RANK is one of a family of receptors that regulates bone and immune homeostasis. In health, RANK, RANK-L and OPG together keep the continual process of bone growth and resorption in balance.

Bone tumors presumably derail this homeostatic process, however, by upregulating RANK-L expression. RANK-L binds to RANK, stimulating the production and activation of osteoclasts (bone cells that increase the breakdown of bone tissue).

OPG counter-regulates RANK-L by blocking its ability to bind to RANK.

Eventual therapeutic interventions may make use of OPG or other RANK-L inhibitors to slow the process of bone destruction in skeletal tumors in cats and dogs, Barger said. Although not a cure, this could reduce the pain and other complications associated with bone cancer. Such therapies have proven effective at reducing pathologic bone loss in human bone cancer patients.

The researchers are the first to verify that the expression of this protein, which worsens the effects of bone cancer in humans, also occurs in cats and dogs with skeletal tumors. Their study appears in the January-February issue of the Journal of Veterinary Internal Medicine.

“Osteosarcoma is much more common in veterinary medicine than in human medicine,” Barger said. “And in dogs it is fairly common.”

Other studies have reported a tenfold
'"/>




Page: 1 2

Related medicine news :

1. Study Offers Insights Into Treatment Of Rheumatoid Arthritis
2. Reindeer Provide Valuable Insights Into Sleep Disorders
3. Insights Into Lead Pollution
4. Effect of Osteosarcoma predicted by scans
5. Hypertensive Drug Improves Sexual Dysfunction in Hypertensive Men
6. Steps To Improve Quality Of Plant-Based Drugs
7. Almonds Improve Cholesterol
8. How to Improve Life Expectancy
9. Sage Improves Memory
10. Protein said to Improve Muscle Loss
11. Ultrasound Screening Could Improve The Outcome Of Critically ill Patients
Post Your Comments:
(Date:1/22/2015)... January 23, 2015 The U.S. Pharmacopeial ... DICVP, Director of Clinical Pharmacy Services at North Carolina ... recipient of the 2015 Beal Award for Distinguished Volunteer ... has relied on the contributions of volunteer experts to ...
(Date:1/22/2015)... January 22, 2015 The City of West Hollywood ... a.m., to commemorate the 42nd anniversary of the Supreme Court decision ... “It’s been 42 years since the Roe vs. Wade decision and ... as present as ever,” said City of West Hollywood Councilmember Abbe ...
(Date:1/22/2015)... Padre Murphy's and Owner Tom Boyle in Glendale, AZ has ... (PPHA). The PPHA's passion for others' well-being and shared ... treated for obstructive sleep apnea (OSA) has propelled them into ... the valley. The most recent plans for an event will ...
(Date:1/22/2015)... 23, 2015 Angelweddingdress is a famous wedding ... its customers to follow it on Facebook, Twitter, and Pinterest. ... Day gift. Angelweddingdress draws a lottery every week. , Moreover, ... Feb. 28, 2015. Click Angelweddingdress homepage for more ...
(Date:1/22/2015)... The federal court overseeing thousands of vaginal ... Southern District of West Virginia has upheld a $2 million ... bellwether trial. In an Order dated January 21st, the Court ... that C.R. Bard had not proven a miscarriage of justice. ...
Breaking Medicine News(10 mins):Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 2Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 3Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 4Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4
... Now! Coalition applauds the House,s important decision to allocate ... American Recovery and Reinvestment Act for incentives to promote ... this outcome," Joel White, executive director of the Coalition ... coalition has advocated for legislation with significant funding provisions ...
... Jan. 29, 2009 Mice whose fat cells were allowed to ... when fed a high-fat diet, researchers at UT Southwestern Medical Center ... mice lacked a protein called collagen VI, which normally surrounds fat ... around a water balloon. The findings appear online and in a ...
... that exercise may be a factor in recovering from ... and knee osteoarthritis (OA). One study involving a progressive ... it enhanced clinical improvement almost to the level of ... examine the relationship between four components of physical activity ...
... (OA) causes disability and is a major public health ... 4 and 6 sulfate (CS) on OA progression and ... dietary supplements in the U.S., has been approved as ... many European countries. The study was published in the ...
... North State Bancorp (OTC,Bulletin Board: NSBC) (the "Company"), the ... $687.6 million as of December 31, 2008,compared to total ... increase,of $140.1 million or 25.6%. , ... 31, 2008 were $612.7,million and total loans were $546.4 ...
... smoking laws make it this year,s worst city for asthmatics, ... Louis is now the 2009 "Asthma Capital of the United ... annual ranking of the 100 most challenging places to live ... 2008, St. Louis went to the top of this year,s ...
Cached Medicine News:Health News:UT Southwestern researchers identify protein that may explain 'healthy' obesity 2Health News:Exercise plays large role in recovery from knee replacement and the occurrence of osteoarthritis 2Health News:Exercise plays large role in recovery from knee replacement and the occurrence of osteoarthritis 3Health News:Chondroitin slows progression and relieves symptoms of knee osteoarthritis 2Health News:North State Bancorp Reports Profitable 2008 2Health News:North State Bancorp Reports Profitable 2008 3Health News:North State Bancorp Reports Profitable 2008 4Health News:North State Bancorp Reports Profitable 2008 5Health News:North State Bancorp Reports Profitable 2008 6Health News:St. Louis Ranked America's 'Asthma Capital' 2
(Date:1/22/2015)... 22, 2015 Research and Markets ( http://www.researchandmarkets.com/research/3h534b/infectious ... Disease Diagnostics Market by Product, Application, Technology, End User ... offering. , The infectious disease diagnostics market ... reach $18,156.2 million by 2019 from $12,422.8 million in ...
(Date:1/22/2015)... and Markets ( http://www.researchandmarkets.com/research/w25xpc/allergy ) has announced the ... Product & by End User - Global Forecast to 2019" ... allergy diagnostics market is valued at $1,228.58 million in 2014 ... to reach $2,230.72 million by 2019. Allergy diagnostics is used ...
(Date:1/22/2015)... 22, 2015 Research and Markets ( http://www.researchandmarkets.com/research/tl6pqb/xray_detectors ) ... by Detector Type, Applications & by FPD Panel Size - ... , The X-ray detectors market is a growing ... its inception, such as a shift from film to filmless ...
Breaking Medicine Technology:Global Infectious Disease Diagnostics (Instruments, Reagents, Services, Software) Market - Forecast to 2019 2Global Infectious Disease Diagnostics (Instruments, Reagents, Services, Software) Market - Forecast to 2019 3Global Allergy Diagnostics (Immunoassay Analyzer, Luminometer, Assay Kit, Consumables) Market - Forecast to 2019 2Global Allergy Diagnostics (Immunoassay Analyzer, Luminometer, Assay Kit, Consumables) Market - Forecast to 2019 3Global X-Ray Detectors (Flat Panel, Computed Radiography, CCD, Line-Scan) Market - Forecast to 2019 2Global X-Ray Detectors (Flat Panel, Computed Radiography, CCD, Line-Scan) Market - Forecast to 2019 3
... March 23, 2011 DATATRAK International, Inc. (OTCQX: ... global eClinical solutions for the clinical trials industry, ... Association,s EuroMeeting. The 23rd Annual EuroMeeting will address ... evaluating the benefits new science and technologies are ...
... (NYSE: BSX ) today announced that it will ... 60th Annual Scientific Session of the American College of Cardiology/i2 ... on its Cardiology, Rhythm and Vascular (CRV) Group initiatives involving ... to begin at 6 p.m. CT and adjourn at approximately ...
Cached Medicine Technology:DATATRAK to Attend DIA's 23rd Annual EuroMeeting 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: