Navigation Links
Insights into Osteosarcoma in Cats and Dogs may Improve Palliative Care

Researchers at the University of Illinois have found that a molecular pathway known to have a role in the progression of bone cancer in humans is also critical to the pathology// of skeletal tumors in dogs and cats. Their work could lead to advances in the palliative care of companion animals afflicted with osteosarcoma.

The research team, which included U. of I. pathobiology professor Anne Barger, examined the homeostatic role of an enzyme, receptor activator of nuclear factor kappa-B (known as RANK), and two key modulators of its activity: RANK ligand (RANK-L) and osteoprotegrin (OPG). RANK is one of a family of receptors that regulates bone and immune homeostasis. In health, RANK, RANK-L and OPG together keep the continual process of bone growth and resorption in balance.

Bone tumors presumably derail this homeostatic process, however, by upregulating RANK-L expression. RANK-L binds to RANK, stimulating the production and activation of osteoclasts (bone cells that increase the breakdown of bone tissue).

OPG counter-regulates RANK-L by blocking its ability to bind to RANK.

Eventual therapeutic interventions may make use of OPG or other RANK-L inhibitors to slow the process of bone destruction in skeletal tumors in cats and dogs, Barger said. Although not a cure, this could reduce the pain and other complications associated with bone cancer. Such therapies have proven effective at reducing pathologic bone loss in human bone cancer patients.

The researchers are the first to verify that the expression of this protein, which worsens the effects of bone cancer in humans, also occurs in cats and dogs with skeletal tumors. Their study appears in the January-February issue of the Journal of Veterinary Internal Medicine.

“Osteosarcoma is much more common in veterinary medicine than in human medicine,” Barger said. “And in dogs it is fairly common.”

Other studies have reported a tenfold greater incidence of bone cancer in dogs than in humans.

“Owners often make decisions to euthanize based on pain,” Barger said. “If we can lessen the pain associated with the tumor we can improve the quality of life and the lifespan.”

Source-Bio-Bio TechnologyBR>SRM
'"/>




Related medicine news :

1. Study Offers Insights Into Treatment Of Rheumatoid Arthritis
2. Reindeer Provide Valuable Insights Into Sleep Disorders
3. Insights Into Lead Pollution
4. Effect of Osteosarcoma predicted by scans
5. Hypertensive Drug Improves Sexual Dysfunction in Hypertensive Men
6. Steps To Improve Quality Of Plant-Based Drugs
7. Almonds Improve Cholesterol
8. How to Improve Life Expectancy
9. Sage Improves Memory
10. Protein said to Improve Muscle Loss
11. Ultrasound Screening Could Improve The Outcome Of Critically ill Patients
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2017)... ... January 20, 2017 , ... “Knowledge is God’s Lighthouse”: a ... “Knowledge is God’s Lighthouse” is the creation of published author, Gene Gaapf, a retired ... collections. , “I have been writing since high school and have many different ...
(Date:1/19/2017)... ... January 20, 2017 , ... Today, the Centers for Medicare & ... of CMS’s Alternative Payment Models (APMs) in 2017. Clinicians who participate in APMs are ... an important part of the Administration’s effort to build a system that delivers better ...
(Date:1/19/2017)... Ocala, Florida (PRWEB) , ... January 19, 2017 ... ... multi-million dollar 5,000 SF expansion and facility enhancement of their 503A compounding pharmacy ... To meet the growing demand of physicians and patients throughout the United States ...
(Date:1/19/2017)... ... January 19, 2017 , ... LabRoots , the leading ... the world, announces the launch of its newly redesigned website. The sleek new ... breakthroughs and trending news, vital information on upcoming virtual events and webinars, all ...
(Date:1/19/2017)... CA (PRWEB) , ... January 19, 2017 , ... Cosmetic ... of plastic surgery procedures in order to make it easier for their readers to ... of the body they impact as well as the techniques used on those particular ...
Breaking Medicine News(10 mins):
(Date:1/20/2017)... , Jan. 20, 2017  Palladian Health, ... has announced the launch of an opioid management ... guidelines on opioids and helps stem the growing ... often prescribed to treat chronic non-cancer pain (back ... serious risks and lack of evidence regarding long-term ...
(Date:1/20/2017)... 2017 Avillion LLP, a co-developer and financier ... Weinberg , MD MBA as Chief Medical Officer. Dr Weinberg will ... . ... Weinberg has spent more than 17 years as a pharmaceutical and ... micro-cap biotech. Over the course of his career, he has interfaced ...
(Date:1/19/2017)... YORK , Jan. 19, 2017 Report ... Ophthalmic Devices Market? Which areas are going to grow ... potential revenues to 2026, assessing data, trends, opportunities and ... and graphs. Discover the most lucrative areas in the ... lets you assess forecasted sales across the all the ...
Breaking Medicine Technology: