Navigation Links
Insights into Osteosarcoma in Cats and Dogs may Improve Palliative Care

Researchers at the University of Illinois have found that a molecular pathway known to have a role in the progression of bone cancer in humans is also critical to the pathology// of skeletal tumors in dogs and cats. Their work could lead to advances in the palliative care of companion animals afflicted with osteosarcoma.

The research team, which included U. of I. pathobiology professor Anne Barger, examined the homeostatic role of an enzyme, receptor activator of nuclear factor kappa-B (known as RANK), and two key modulators of its activity: RANK ligand (RANK-L) and osteoprotegrin (OPG). RANK is one of a family of receptors that regulates bone and immune homeostasis. In health, RANK, RANK-L and OPG together keep the continual process of bone growth and resorption in balance.

Bone tumors presumably derail this homeostatic process, however, by upregulating RANK-L expression. RANK-L binds to RANK, stimulating the production and activation of osteoclasts (bone cells that increase the breakdown of bone tissue).

OPG counter-regulates RANK-L by blocking its ability to bind to RANK.

Eventual therapeutic interventions may make use of OPG or other RANK-L inhibitors to slow the process of bone destruction in skeletal tumors in cats and dogs, Barger said. Although not a cure, this could reduce the pain and other complications associated with bone cancer. Such therapies have proven effective at reducing pathologic bone loss in human bone cancer patients.

The researchers are the first to verify that the expression of this protein, which worsens the effects of bone cancer in humans, also occurs in cats and dogs with skeletal tumors. Their study appears in the January-February issue of the Journal of Veterinary Internal Medicine.

“Osteosarcoma is much more common in veterinary medicine than in human medicine,” Barger said. “And in dogs it is fairly common.”

Other studies have reported a tenfold greater incidence of bone cancer in dogs than in humans.

“Owners often make decisions to euthanize based on pain,” Barger said. “If we can lessen the pain associated with the tumor we can improve the quality of life and the lifespan.”

Source-Bio-Bio TechnologyBR>SRM
'"/>




Related medicine news :

1. Study Offers Insights Into Treatment Of Rheumatoid Arthritis
2. Reindeer Provide Valuable Insights Into Sleep Disorders
3. Insights Into Lead Pollution
4. Effect of Osteosarcoma predicted by scans
5. Hypertensive Drug Improves Sexual Dysfunction in Hypertensive Men
6. Steps To Improve Quality Of Plant-Based Drugs
7. Almonds Improve Cholesterol
8. How to Improve Life Expectancy
9. Sage Improves Memory
10. Protein said to Improve Muscle Loss
11. Ultrasound Screening Could Improve The Outcome Of Critically ill Patients
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/17/2018)... (PRWEB) , ... October 17, 2018 , ... ... for Prisoner Health and Human Rights identifies best practices in the management of ... The report notes that LGBT youth are overrepresented in the juvenile justice system, ...
(Date:10/16/2018)... ... ... With a petition (case CJ-2018-04177) filed last week in Tulsa County District Court, ... filed in states around the country against Massage Envy that seek to stop a ... therapists. , This lawsuit alleges that the company's corporate policies and practices are ...
(Date:10/16/2018)... FALLS CHURCH, Va. (PRWEB) , ... October 16, ... ... by FDAnews**, Oct. 23-25, 2018 – Bethesda, MD, http://www.fdanews.com/fdainspectionssummit , The ... changed since last year’s Inspections Summit that it sometimes feels difficult to keep ...
(Date:10/16/2018)... ... October 16, 2018 , ... AutismOne, the nation’s ... proceedings of the 4th Annual International HPV Vaccine Education Symposium. , Presenters from ... 22, 2019, through Friday, May 24, 2019, with a keynote address from Robert ...
(Date:10/13/2018)... ... ... Convoy of Hope’s Disaster Services Team is currently in Marianna, Florida — ... to serve hurricane survivors with water, food, baby products, hygiene kits, flood buckets, tarps ... of supplies are in motion to Florida. , Convoy’s walk-up and drive-thru ...
Breaking Medicine News(10 mins):
(Date:10/16/2018)... (PRWEB) , ... October 16, 2018 , ... ... of Applied Logic, the St. Louis based surgical tracking software company. Censis is ... their customers and employees to make a difference using their strong portfolio of ...
(Date:10/16/2018)... ... October 16, 2018 , ... Ripple Massage, Australia’s leading mobile ... green clay facials and peppermint foot soaks to its packages. , “Ripple is much ... “We feel our clients still want all the pampering extras when they book a ...
(Date:10/16/2018)... ... October 16, 2018 , ... The ... international multidisciplinary group of healthcare treatment providers who treat the full spectrum of ... in a live, two-day, 12-hour track at Symposium 2019. The courses are ...
Breaking Medicine Technology: