Navigation Links
Insecticide and Repellent Combo Effective in Eliminating Malarial Mosquitoes

Researchers have revealed that combining a non-pyrethroid insecticide, propoxur, and a repellent, N,N-diethyl toluamide may prove to be an effective insecticide-repellent synergy against mosquitoes responsible for malaria transmission to humans.

A combination of the two had proved to be much more effective than the straightforward addition of their respective properties. Mosquito nets soaked with this mixture had a lethal power and irritant effect that inhibited the mosquitoes from biting. Moreover, the mosquitoes are hit by a powerful paralysing action, known as the knockdown effect, on contact with the mixture.

The mortality rates determined were satisfactory, in that they equalled those obtained by using deltamethrin, a commonly used synthetic pyrethroid, highly effective against mosquitoes.

The researchers tested two mixtures composed of a non-pyrethroid insecticide of the organophosphate family, combined with either a standard repellent, DEET, or with a new-generation synthetic repellent. Both of these mixtures show a strong synergy in the resulting lethal and paralysing effects on the mosquitoes. However, only the association between the insecticide and the standard repellent produced a synergistic effect that inhibited the mosquito from taking its blood feed.

A synergistic effect was also observed with regard to the treatments residual efficacy, which is several months longer than that of either agent applied alone. The advantage of the synergistic property of these combinations is enhanced by the fact that it significantly reduced the necessary effective doses against the mosquitoes (about 6 times that of the insecticide applied alone), to attain an efficacy equivalent to that of deltamethrin.

The nets treated with the two mixtures in the laboratory were subsequently tested in field trials, in the rice-growing area 40 km North of Bobo-Dioulasso, in Burkina Faso. This area has the specif icity of harbouring two different forms of Anopheles gambiae. The first appears in May and June in the rice-fields. It shows no resistance to pyrethroids. The second emerges in September and October in puddles left by monsoon rains. These do show resistance to these insecticides.

As expected, the usual pyrethroid-treated nets turned out to be effective only against non-resistant mosquitoes of the first population. Conversely, the nets pre-soaked with non-pyrethroidrepellent combinations proved excellent protection for the people of the local villages, whatever the population of mosquitoes present.

Nevertheless, their residual efficacy (about 15 days) in real conditions did not match the researchers expectations. The team consequently envisage working in conjunction with a company able to devise a system for encapsulating the mixture to prolong the residual life of treated mosquito nets.

The efficacy of these mixtures between organophosphates and repellents therefore opens up a new pathway towards controlling pyrethroid-resistant malaria vectors. In the long term, the researchers plan to test their method on mosquitoes resistant to two other types of insecticide utilized against malaria transmission: organophosphates and carbamates.


Related medicine news :

1. Leukaemia May Be Triggered By Insecticides
2. Health of Mothers and Children Show Improvement after Use of Insecticide-Treated Bed Nets
3. Clothes Treated with Insecticide Reduces the Risk of Malarial Infection
4. Insecticide-treated Bed Nets to Combat Malaria in Older Children and Adults
5. Electronic Mosquito Repellents Fail to Prevent Malaria Transmission
6. Drug Combo Works Better for children with ADHD, Tics
7. Scanning Combo Helps Detect Lung Cancer
8. Relief From Asthma With New Combo Therapy
9. Calcium-Vitamin D Combo For Reduced Fracture Risk
10. Drug Combo Improves Performance Of Multiple Sclerosis Drug
11. Alcohol-illusion: Alcohol and Energy Drinks Combo, Maintains Sobriety?
Post Your Comments:

(Date:11/25/2015)... ... 25, 2015 , ... TyloHelo Inc , North America’s ... Sauna accessories help improve the bather experience in the sauna, and the accessories ... the purist looking for simplicity in design to accessories that encourage a greater ...
(Date:11/25/2015)... TX (PRWEB) , ... November 25, 2015 , ... For ... the companies’ “ Two Organizations, One Beat ” campaign. The partnership between the two ... services to aid in MAP International’s cause. , MAP International was founded in 1954 ...
(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... On November ... training center for the Narconon network, announced the release of a new cutting edge ... the Narconon organization has been working with drug- and alcohol-addicted individuals with the purpose ...
(Date:11/25/2015)... ... ... Smiles by Stevens is pleased to announce the addition of Botox® for the ... of the benefits of Botox® in the treatment of moderate facial wrinkling, few have ... pain as a result of Jaw Tension, TMJ (temporo-mandibular joint) disorder, and Bruxism (the ...
(Date:11/25/2015)... ... ... In an ongoing Clinical Study conducted by an independent physician, Andrew Gostine, MD, ... the efficacy of its product and its disinfection protocol. This study is taking place ... through October 2015 at a 360-bed, acute-care, academic medical center located in Chicago, Illinois. ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... -- The American Academy of Pediatrics (AAP), American Congress ... of Dimes cheered today,s signature into law of ... 2015 (S.799), which takes much-needed strides to ... drugs, such as opioids, and to improve their ... have worked together leading advocacy efforts for its ...
(Date:11/25/2015)... Nov. 25, 2015 AAIPharma Services Corp./Cambridge ... of at least $15.8  Million to expand its ... NC . The expansion will provide additional ... the growing demands of the pharmaceutical and biotechnology ... expansion will provide up to 40,000 square feet ...
(Date:11/25/2015)... 2015  ARKRAY USA , Inc., ... evidence demonstrating the accuracy of its blood glucose meter ... Resistance, Diabetes and Cardiovascular Disease in Los ... GLUCOCARD ® 01 meter and the Assure ® ... ability to accurately measure glucose levels in blood is ...
Breaking Medicine Technology: