Navigation Links
Initiation Of New Study To Help Children With Sickle Cell Anaemia

SCA is an inherited disease in which the oxygen-carrying protein in the red blood cells is abnormal, giving the red cells a twisted (sickled) shape that can disrupt circulation, leading to pain, stroke, and other disabling and sometimes fatal complications. //

"Sickle cell anemia is a relentless disease that increasingly disables children as they grow," according to Dr.Ware, an expert in the field of Haematology.

The current treatment for children with SCA who have suffered strokes includes monthly blood transfusions to provide red cells that are not sickled. This ongoing treatment must later be combined with nightly injections of a drug (Desferal ?) that eliminates excessive iron buildup caused by regular blood transfusions.

Excessive iron damages internal organs--a condition called haemochromatosis. The nightly injections of Desferal, an iron chelator (molecules that bind to metals so they can be eliminated from the body), are painful and inconvenient, often prompting children to forego the injection, since iron buildup does not initially cause the child discomfort, but the injections always do.

In an attempt to increase the compliance level of the patients to the therapy, a national Phase III clinical trial to investigate whether a new combination treatment can prevent a secondary stroke in children with sickle cell anemia (SCA) and eliminate the need for nightly injections with a drug that reduces iron overload in these patients has been planned.

The study named Stroke With Transfusions Changing to Hydroxyurea (SWiTCH ) has been designed to determine if hydroxyurea can replace blood transfusions and if monthly blood withdrawal can substitute for daily injections to treat iron overload.

The goal of SWiTCH is to compare patient outcomes using blood transfusions with outcomes using hydroxyurea. Hydroxyurea will not completely eliminate the sickled red cells, but it is expected to stimulate production of eno ugh red cells carrying fetal hemoglobin to reduce SCA symptoms.

The study will also compare the efficacy of daily at-home injections of Desferal with the less painful and more convenient monthly removal of blood (phlebotomy) at a medical facility. Half of the children in SWiTCH will remain on the standard treatment (transfusions and chelator) while the other half will be treated with the alternative treatment (hydroxyurea and phlebotomy).

The study is supported by a grant of more than $18 million from the National Institutes of Health (National Heart, Lung, and Blood Institute) and includes 20 major pediatric sickle cell centers.

SWiTCH holds promise for greatly simplifying and improving the long-term care of children with the disease who have suffered strokes and finally give a better way to enhance the lives of children who are fighting it hard against the disease.


'"/>




Related medicine news :

1. Depression May Be A Risk Factor For Cancer Initiation
2. Understanding Cancer Initiation Could Help In Early Detection And Prevention
3. Tomato Sauce reduces Cancer Risk- Study
4. Study on obesity and heart failure
5. National Lung Study in the process
6. Study casts doubt on keyboard ills
7. Study reveals how stress can make you sick
8. Study reveals how stress can make you sick
9. Study supports vegetable diet
10. Study to look at early surgery to treat epilepsy
11. Its Never Too Late to Stop Smoking,Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... ... March 24, 2017 , ... According to a new study by NCPA ... does not obey the rules Congress has directed the CBO to follow. The CBO ... reform would restore. Yet, it estimates a reduction in employer-based coverage due to the ...
(Date:3/24/2017)... ... , ... The iaedp Foundation, the premier provider of educational programs and training ... the full spectrum of disordered eating, announced today that the 2017 Symposium set a ... states and several countries converged on the Green Valley Resort in Las Vegas. ...
(Date:3/24/2017)... ... 24, 2017 , ... Shamanic healer and teacher Anahata Ananda ... Spiritual Awakening, proudly presents her Sacred Peru retreat with world famous shaman ... journey during the Summer Solstice will also be her final international retreat, Anahata ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... wanted to create a communications platform that positions them as the go-to thought ... ONS reinvented their online publication as an always-on, always-fresh news, views and advocacy ...
(Date:3/24/2017)... ... March 24, 2017 , ... On June 9, 2017, ... Claims Litigation seminar in Chicago, Illinois. She will present on: , Filing ... litigated under ERISA involve claims for long-term disability benefits. This session will ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... Mar 24, 2017 Research and Markets has ... Strategic Business Report" report to their offering. ... The report provides separate comprehensive analytics for the ... Europe , Asia-Pacific , Latin ... provided for the period 2015 through 2022. Also, a six-year historic analysis ...
(Date:3/24/2017)... , March 24, 2017  Eli Lilly ... announced plans to invest $850 million in its ... facilities across its U.S. enterprise, including research laboratories, ... investments are being driven by demand for Lilly ... potential medicines in development targeting cancer, pain, diabetes ...
(Date:3/24/2017)... 2017  Mirabilis Medical, a Seattle ... non-invasive surgery, announced today CE Mark authorization for ... uterine fibroids throughout the European Union.  The company ... the US Food and Drug Administration to begin ... the United States.  The Mirabilis System combines high-speed ...
Breaking Medicine Technology: