Navigation Links
Initial Steps In Spread Of Cancer Identified

Scientists have now discovered how cancer cells are able to spread to distant parts of the body. It was previously though that these cells spread to the target site via the blood or the lymph// and then started forming a new tumor there.

It has now emerged that certain chemicals secreted by the tumors do the job of preparing the potential "landing" site by altering the conditions to make them ideal for cancer growth. Researchers from the Cornell University's Weill Medical College in New York have published their findings in today's issue of the journal Nature. Their study demonstrates that cancer cells induce certain bone marrow cells to migrate to distant organs and prepare the site for further colonization by the tumor. If these bone marrow cells can be blocked by drugs, then the spread of cancer, which is what makes the disease so deadly can be easily contained, "These nests provide attachment factors for the tumor cells to implant and nurture them. It causes them not only to bind but to proliferate. Once that all takes place we have a fully formed metastatic site or secondary tumor," said Lead researcher Dr David Lyden. He added that for the first time the initial steps involved in metastasis were mapped out. "By blocking bone marrow cells using antibodies, we are capable of preventing tumor cells implanting and thus the spread of cancer," he observed.

The current study shows that the initial protein that is sent out as an emissary is fibronectin. Once it has entrenched into the area, a second growth factor arrives and thus bone marrow cells can easily colonize this area. Once this happens, malignant cells that arrive later have a foundation that can begin the formation of secondary cancer. These steps were shown in mice, whose bone marrow cells were killed by irradiation. The researchers then injected skin cancer and lung cancer cells into these mice after supplying bone marrow cells tagged with green fluorescent protein. This enabled them t o track the progress of the cells in the body. The cancer cells were tagged with red fluorescent protein. The researchers found that green cells appeared in the lungs many days before the actual tumor cells arrived, thus signaling that they were preparing the site for invasion of the cancer cells.


'"/>




Related medicine news :

1. Detecting Lung Cancer In Its Initial Stages
2. New Screening Method Found To Detect Testicular Cancer In Its Initial Stages
3. Initial tests negative for bird flu in Romanian Woman
4. Elastrography, may Call the Shots During Initial Stage of Breast Screening
5. Steps To Improve Quality Of Plant-Based Drugs
6. Few Simple Steps to Lower The Incidence Of SIDS
7. Simple Steps To Help Fight Asthma
8. WHO Steps Up To Create A Public Awareness About The Consequences Of Exposure To Radon
9. Steps Taken To Maintain Inflation Rates Says Chidambaram
10. Government Takes Steps to Reduce Binge Drinking Among Britons
11. Its High Time the Australian Government Takes Steps against Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... Charlotte, NC (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind ... able to be personalized through a fitness app. The fitness app plans to fix the ... solutions currently only offer a one size fits all type program , They ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery ... of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , ... for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency ... named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. ... Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director ...
(Date:6/25/2016)... ... 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland ... iHire in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness ... & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may ... to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To ... for healthy coping following a traumatic event. , Trauma sufferers tend to feel a ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced ... BRAHMS PCT (procalcitonin) assay as a dedicated testing solution ... this clearance, Roche is the first IVD company in ... sepsis risk assessment and management. PCT is ... levels in blood can aid clinicians in assessing the ...
(Date:6/23/2016)... 2016 Capricor Therapeutics, Inc. ... biotechnology company focused on the discovery, development and ... enrollment in its ongoing randomized HOPE-Duchenne clinical trial ... of its 24-patient target. Capricor expects the trial ... of 2016, and to report top line data ...
(Date:6/23/2016)... Bracket , a leading clinical trial technology and specialty ... Bracket eCOA (SM) 6.0, at the 52 nd ... in Philadelphia , Pennsylvania.  A demonstration of ... its kind to fully integrate with RTSM, will be held ... a flexible platform for electronic clinical outcomes assessments that is ...
Breaking Medicine Technology: