Navigation Links
Inhibitor That Blocks Host Receptors Found To be Effective In Treating Anthrax

A team of American and Canadian scientists from Rensselaer Polytechnic Institute in Troy, N.Y., and the University of Toronto have developed a new anthrax// inhibitor that blocks the host receptors where anthrax toxin attaches in the body.

The researchers said that the inhibitor was able to bind to multiple sites on the host receptor making it much for potent than the inhibitors that binds to single site. The researchers found that the new approach led to a 50,000-fold increase in activity to block multiple binding sites when compared with a more conventional inhibitor. They found that all six rats that got these inhibitors were protected against the toxins and had no adverse effects.

Anthrax is a serious disease caused by bacteria, Bacillus anthracis, which can affect both human and animals. The B. anthracis when inhaled, as when used as a biological weapon, is much more serious and can be fatal despite treatment with antibiotics. Most therapies including antibiotics used to treat anthrax are targeted against the bacteria or the toxin released by the bacteria that damages the host organism.

However, these bacteria can become resistant to antibiotics over time, and resistance can also be engineered intentionally into a germ as when used as a biological weapon. Also, the antibiotic used only slows the progression of infection, but do not counter the effects of the toxins once an infection takes hold.

However, the use of anthrax inhibitor could help address this issue as they block the receptor sites used by the bacteria to gain a lethal foothold in the body and thus can help reduce the number of deaths caused by inhaled anthrax once it is fully developed. According to the federal Centers for Disease Control and Prevention, inhaled anthrax still has a fatality rate of 75 percent even after antibiotics are given.

Ravi Kane, an associate professor of chemical and biological engineering at Rensselaer Polyte chnic Institute in Troy, N.Y., and the co-author of the study said "combining the inhibitor with antibiotic therapy may increase the likelihood of survival for an infected person." He said that instead of trying to constantly match evolutionary changes in bacteria and viruses blocking the host receptors was a better approach for treatment.

The researchers said that the same approach could be used to design blocking agents to protect against other diseases including SARS, flu and AIDS.


SAR
'"/>




Related medicine news :

1. Aromatase Inhibitors drug Femara after Tamoxifen therapy protects from breast cancer recurrence
2. Macrophage Inhibitory Factor Causes Multiple Sclerosis Progression
3. Rejuvenation of Stem cells by GSK-3 Inhibitor
4. LipB Protein Inhibitors Help To Fight Against TB
5. Birth Defects Link With ACE Inhibitor Use, FDA Reports
6. Aromatase Inhibitors Better Than Tamoxifen For Treating Receptor-Positive Early Breast Cancer
7. ACE Inhibitors For Vascular Disease Patients
8. Reducing the Risk of Protease Inhibitor-Related Atherosclerosis
9. Study Finds Astaxanthin Is Potent Inhibitor of Oxidation in Cell Membrane Model
10. New Protein Inhibitor Halts Growth Of Cancerous Cells
11. Early Switch to an Aromatase Inhibitor Increases Survival
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/18/2017)... ... February 18, 2017 , ... ProParagraph Fashion ... Film Studios ’ ProParagraph Fashion Volume 2 for all multi-line FCPX project needs. ... Users can pick and choose from hand-crafted trend-setting designs with smooth animations that ...
(Date:2/17/2017)... ... February 17, 2017 , ... The Alliance Healthcare ... designed to further positively impact the health and wellness of our community in ... it our duty to seriously consider releasing our assets beyond our 5% targeted ...
(Date:2/17/2017)... Palos Verdes, CA (PRWEB) , ... February 17, ... ... and emotional flow is Dr. Carol Francis' goals for each and ... Retreat Conference, Dr. Carol Francis will demonstrate five different brainwave tools which help ...
(Date:2/17/2017)... ... 2017 , ... Program will serve more than 5,000 kids ... Soccer Foundation announced today that they have awarded nine grants to expand the ... soccer mentoring program, teaches kids the fundamentals of soccer while striving to help ...
(Date:2/17/2017)... ... 17, 2017 , ... Cancer diagnostics workflow solution provider Inspirata, ... – 22 in San Francisco. As part of the Tri-Conference expo, which is ... solution, as well as its new precision medicine platform, “Crosswalk Insight: Oncology™.” , ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... Feb. 17, 2017  Perrigo Company plc (NYSE, TASE: PRGO) today ... and Drug Administration for hydrocodone bitartrate and homatropine methylbromide oral ... Hydrocodone bitartrate and homatropine methylbromide oral solution (syrup), 5 ... relief of cough in adults and children 6 years of ... January 2017 were approximately $16 million.   ...
(Date:2/17/2017)... , Feb 17, 2017 Research and Markets has ... Report" report to their offering. ... The report provides separate comprehensive analytics for the US, ... , Asia-Pacific , Latin America , ... period 2015 through 2022. Also, a six-year historic analysis is provided for ...
(Date:2/17/2017)... 17, 2017  In partnership with CitiHope , ... Health , The Jack Brewer Foundation (JBF ... of dollars, worth of medicine to Innovating Health ... IHI is a non-profit dedicated to treating chronic diseases and addressing ... in Haiti and providing these ...
Breaking Medicine Technology: