Navigation Links
Inhibitor That Blocks Host Receptors Found To be Effective In Treating Anthrax

A team of American and Canadian scientists from Rensselaer Polytechnic Institute in Troy, N.Y., and the University of Toronto have developed a new anthrax// inhibitor that blocks the host receptors where anthrax toxin attaches in the body.

The researchers said that the inhibitor was able to bind to multiple sites on the host receptor making it much for potent than the inhibitors that binds to single site. The researchers found that the new approach led to a 50,000-fold increase in activity to block multiple binding sites when compared with a more conventional inhibitor. They found that all six rats that got these inhibitors were protected against the toxins and had no adverse effects.

Anthrax is a serious disease caused by bacteria, Bacillus anthracis, which can affect both human and animals. The B. anthracis when inhaled, as when used as a biological weapon, is much more serious and can be fatal despite treatment with antibiotics. Most therapies including antibiotics used to treat anthrax are targeted against the bacteria or the toxin released by the bacteria that damages the host organism.

However, these bacteria can become resistant to antibiotics over time, and resistance can also be engineered intentionally into a germ as when used as a biological weapon. Also, the antibiotic used only slows the progression of infection, but do not counter the effects of the toxins once an infection takes hold.

However, the use of anthrax inhibitor could help address this issue as they block the receptor sites used by the bacteria to gain a lethal foothold in the body and thus can help reduce the number of deaths caused by inhaled anthrax once it is fully developed. According to the federal Centers for Disease Control and Prevention, inhaled anthrax still has a fatality rate of 75 percent even after antibiotics are given.

Ravi Kane, an associate professor of chemical and biological engineering at Rensselaer Polyte chnic Institute in Troy, N.Y., and the co-author of the study said "combining the inhibitor with antibiotic therapy may increase the likelihood of survival for an infected person." He said that instead of trying to constantly match evolutionary changes in bacteria and viruses blocking the host receptors was a better approach for treatment.

The researchers said that the same approach could be used to design blocking agents to protect against other diseases including SARS, flu and AIDS.


Related medicine news :

1. Aromatase Inhibitors drug Femara after Tamoxifen therapy protects from breast cancer recurrence
2. Macrophage Inhibitory Factor Causes Multiple Sclerosis Progression
3. Rejuvenation of Stem cells by GSK-3 Inhibitor
4. LipB Protein Inhibitors Help To Fight Against TB
5. Birth Defects Link With ACE Inhibitor Use, FDA Reports
6. Aromatase Inhibitors Better Than Tamoxifen For Treating Receptor-Positive Early Breast Cancer
7. ACE Inhibitors For Vascular Disease Patients
8. Reducing the Risk of Protease Inhibitor-Related Atherosclerosis
9. Study Finds Astaxanthin Is Potent Inhibitor of Oxidation in Cell Membrane Model
10. New Protein Inhibitor Halts Growth Of Cancerous Cells
11. Early Switch to an Aromatase Inhibitor Increases Survival
Post Your Comments:

(Date:11/30/2015)... ... November 30, 2015 , ... ... four states in the U.S. require dental technicians to be certified or obtain ... industry, NADL created the “What’s In Your Mouth?” campaign to inform dentists that ...
(Date:11/30/2015)... MN (PRWEB) , ... November 30, 2015 , ... ... at . The directory is specialized and only includes chiropractic clinics ... to find a competent and trustworthy alternative health practitioner when back pain sets ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... experience this summer, ushering in a new era of publicly accessible automated technology. ... shuttle, will continue to offer guests an up-close look at the shuttle at ...
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... ... and fun atmosphere for Halloween festivities, the Word of Life Christian Church of ... board game, and featuring a giant 1.25 ton pile of candy dubbed “Candy ...
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... ... community across the United States to access life-saving information provided directly ... Mesothelioma will consist of three individual conferences in three major cities: Houston, ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... 30, 2015 Nevro Corp. (NYSE: NVRO ), ... solutions for the treatment of chronic pain, today announced that ... Patent and Trademark Office (USPTO) has denied instituting an ... (the ,102 patent).  --> ... Scientific Corporation filed two petitions challenging the validity of certain ...
(Date:11/30/2015)... SAN FRANCISCO , Nov. 30, 2015 ... and Designers of Things (DoT ) co-located events ... Printing and the Internet of Things, will draw more ... San Jose Convention Center. The events, combined ... their latest technologies. --> ...
(Date:11/30/2015)... and BOCA RATON, Fla. ... for the Commercialization of Public Research (the Institute) ... with KynderMed , a medical device start-up company ... supports new company creation based on publicly-funded research, and ... Florida -based universities and research institutions. ...
Breaking Medicine Technology: