Navigation Links
Inhibitor That Blocks Host Receptors Found To be Effective In Treating Anthrax

A team of American and Canadian scientists from Rensselaer Polytechnic Institute in Troy, N.Y., and the University of Toronto have developed a new anthrax// inhibitor that blocks the host receptors where anthrax toxin attaches in the body.

The researchers said that the inhibitor was able to bind to multiple sites on the host receptor making it much for potent than the inhibitors that binds to single site. The researchers found that the new approach led to a 50,000-fold increase in activity to block multiple binding sites when compared with a more conventional inhibitor. They found that all six rats that got these inhibitors were protected against the toxins and had no adverse effects.

Anthrax is a serious disease caused by bacteria, Bacillus anthracis, which can affect both human and animals. The B. anthracis when inhaled, as when used as a biological weapon, is much more serious and can be fatal despite treatment with antibiotics. Most therapies including antibiotics used to treat anthrax are targeted against the bacteria or the toxin released by the bacteria that damages the host organism.

However, these bacteria can become resistant to antibiotics over time, and resistance can also be engineered intentionally into a germ as when used as a biological weapon. Also, the antibiotic used only slows the progression of infection, but do not counter the effects of the toxins once an infection takes hold.

However, the use of anthrax inhibitor could help address this issue as they block the receptor sites used by the bacteria to gain a lethal foothold in the body and thus can help reduce the number of deaths caused by inhaled anthrax once it is fully developed. According to the federal Centers for Disease Control and Prevention, inhaled anthrax still has a fatality rate of 75 percent even after antibiotics are given.

Ravi Kane, an associate professor of chemical and biological engineering at Rensselaer Polyte chnic Institute in Troy, N.Y., and the co-author of the study said "combining the inhibitor with antibiotic therapy may increase the likelihood of survival for an infected person." He said that instead of trying to constantly match evolutionary changes in bacteria and viruses blocking the host receptors was a better approach for treatment.

The researchers said that the same approach could be used to design blocking agents to protect against other diseases including SARS, flu and AIDS.


SAR
'"/>




Related medicine news :

1. Aromatase Inhibitors drug Femara after Tamoxifen therapy protects from breast cancer recurrence
2. Macrophage Inhibitory Factor Causes Multiple Sclerosis Progression
3. Rejuvenation of Stem cells by GSK-3 Inhibitor
4. LipB Protein Inhibitors Help To Fight Against TB
5. Birth Defects Link With ACE Inhibitor Use, FDA Reports
6. Aromatase Inhibitors Better Than Tamoxifen For Treating Receptor-Positive Early Breast Cancer
7. ACE Inhibitors For Vascular Disease Patients
8. Reducing the Risk of Protease Inhibitor-Related Atherosclerosis
9. Study Finds Astaxanthin Is Potent Inhibitor of Oxidation in Cell Membrane Model
10. New Protein Inhibitor Halts Growth Of Cancerous Cells
11. Early Switch to an Aromatase Inhibitor Increases Survival
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/8/2016)... ... February 08, 2016 , ... ... While a significant number of women and men with eating disorders report a ... that best predicts the development of an eating disorder. , At the ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... ... excited to share this important news! AHCC and the Home Health and Hospice ... Clinic, CMS' designee for official ICD coding guidance and clarifications, to address concerns ...
(Date:2/8/2016)... ... February 08, 2016 , ... The schedule is ... this country. The AutismOne 2016 Conference, which is being held May 25-29 at the ... hear elsewhere about helpful interventions and causes of chronic illness in children. , Very ...
(Date:2/7/2016)... Dallas, Texas (PRWEB) , ... February 07, 2016 ... ... its new MyDecision™ program. MyDecision™ empowers employers and organizations with the tools and ... , MyDecision™ combines three elements to cut the cost of providing employee healthcare ...
(Date:2/6/2016)... ... February 06, 2016 , ... With the FCPX LUT: Summer ... grades to their footage. A LUT is a Lookup Table that contains a mathematical ... color indicated by the table. By manipulating each pixel, LUT's can change each color ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... 8, 2016   HighPoint Solutions today ... (NRG),s pharmacovigilance technology services division.  NRG is a ... an Oracle Argus Specialized partner, providing drug safety ... companies. --> --> ... sciences capabilities and provides a global scale and ...
(Date:2/8/2016)... part of a major growth and expansion initiative, Dune Medical ... Chmura as President of Dune Inc., its U.S. division. ... experience in the medical device space will play a large ... --> --> In her new ... and operational functions in the U.S. She is tasked with ...
(Date:2/8/2016)... Feb. 8, 2016 Velano Vascular, a medical ... hospitalized patients and their practitioners, announced today that the ... Velano will use the proceeds from this financing, an ... in January 2015, to support the development and commercialization ... pediatric populations. Philadelphia , ...
Breaking Medicine Technology: