Navigation Links
Inhibition of morphine tolerance by spinal melanocortin receptor blockade

Recent research suggests that the melanocortin system is an important component influencing the changes in the spinal neuronal plasticity observed after chronic morphine administration//.

The chronic use of morphine is accompanied by the development of morphine tolerance, which is one of the major problems associated with opiate treatment. Possible modulation of opioid effects by melanocortin receptor ligands has been recently demonstrated.

Researchers from Poland, writing in the October issue of the journal Pain, investigated the influence of repeated intrathecal injection of a melanocortin receptor antagonist on the development of morphine tolerance as measured by tail-flick test. It was also examined whether a single administration of the antagonist could counteract the loss of analgesic potency of morphine in morphine tolerant rats. The authors examined also the influence of chronic morphine administration on ì-opioid receptor (MOR) and melanocortin 4 receptor (MC4-R) mRNAs in the rat spinal cord and dorsal root ganglia (DRG) during morphine tolerance.

Morphine treatment over 8 days induced tolerance as reflected by a significant reduction of withdrawal latency from 181 to 25% above baseline in the tail-flick test. Repeated co-administration of morphine and melanocortin receptor antagonist, significantly prevented the development of morphine tolerance.

A single administration of an MC4-R antagonist restored morphine analgesic potency in morphine tolerant rats. Using RT-PCR they demonstrated no changes in the spinal cord but there was a decrease in MOR and increase in MC4-R gene expression in the DRG of rats tolerant to morphine. These results suggest that MC4-R may be involved in the mechanisms of opioid tolerance and antagonists of this receptor may be a possible new target in the search for strategies preventing the development of opioid tolerance. The authors propose that besides other systems, the melanocortin s ystem may also be involved in the changes in spinal neuronal plasticity. The specific MC4-R antagonists would be promising compounds to alleviate the side effects of long-term morphine treatment. Their ability to restore morphine analgesia may have clinical benefits.

The melanocortin receptor antagonist tested may widen the options of the use of opioids for treatment of chronic pain by reducing the need for opioid dose escalation, which is often associated with unwanted side effects and by attenuating the development of analgesic tolerance and hyperalgesia following chronic use of morphine.
'"/>




Related medicine news :

1. Anonymity Helps In Overcoming Inhibitions During Online Counseling
2. Inhibition of Colorectal tumor growth by Grape seed extract
3. Gluten Intolerance Quadruples Susceptibility to Tuberculosis
4. Brain development in teens curbed by alcohol tolerance
5. Exercise Intolerance In Heart Failure Patients Is Explored By Researchers
6. Inflammatory Myopathy may Indicate Intolerance to Gluten
7. Useful device makes spinal surgery safer
8. New hope for spinal cord injury victims
9. Acrolein may be the key to halting spinal cord damage
10. Cervical spinal injury patients may have more damage left undetected
11. New spinal surgery technique developed by UCSF Surgeon
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Dickinson Insurance and Financial ... financial preparation services, is providing an update on a charitable event that began ... Rescue is a locally recognized nonprofit that provides shelter and care for animals ...
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of ... its next President and Chief Executive Officer, succeeding Dr. James C. Puffer upon his ... July 1, 2018 until Dr. Puffer’s retirement at the end of 2018. Upon assuming ...
(Date:10/13/2017)... Ill. (PRWEB) , ... October ... ... Edwardsville School of Pharmacy (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer ... healthcare professionals on guideline updates for the primary prevention of cardiovascular diseases ...
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance ... care insurance companies have a waiver for care if the client has a cognitive ... the family pays for care, is often waived, so the benefits from their insurance ...
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids this ... by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited about ... ages; it is a non-competitive, non-timed event, which is all about having fun and ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... 2017 OBP Medical , a ... devices, today announced regulatory approval from ... Agência Nacional de Vigilância Sanitária (ANVISA)) to market ... retractor with integrated LED light source and smoke ... exposure of a tissue pocket or cavity during ...
(Date:10/2/2017)... 2017  AllianceRx Walgreens Prime, the combined central specialty ... pharmacy benefit manager Prime Therapeutics LLC (Prime), today officially ... the unveiling of new signage at its headquarters in ... at a few other company-owned facilities across the country. ... some of whom will begin to see the AllianceRx ...
(Date:9/28/2017)... , Sept. 28, 2017 Hill-Rom Holdings, Inc. ... earnings conference call and webcast on Friday, November 3, ... (EDT) and ending at approximately 8:30 a.m. (CDT) / ... the company,s 2017 financial performance and guidance for 2018, ... initiatives to enhance operational performance, and long-range financial outlook ...
Breaking Medicine Technology: